Abstract
Continuous data conforming to normal distribution are presented as mean ± standard error, and one-way analysis of variance followed by Tukey's test was used for comparisons. Continuous data that do not conform to normal distribution are presented as median with the 25th percentile and the 75th percentile, and statistical analysis was performed using Kruskal–Walllis H test, followed by Nemenyi test for multiple comparisons. According to the Masson's trichrome staining of BLM group on day 21, a mass of blue-dyed portion revealed the excess accumulation of collagen, which proved the successful establishment of lung fibrosis mice model. According to the HE staining on day 7, the BLM group mice showed extensive alveolar thickening and clear inflammatory infiltrates, and treatment with apyrase markedly reduced the inflammatory response [Figure 1C].
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Details
1 Department of Respiratory and Critical Care Medicine, Characteristic Medical Center of Chinese People's Armed Police Force, Tianjin 300162, China
2 Department of Radiology, Characteristic Medical Center of Chinese People's Armed Police Force, Tianjin 300162, China
3 Department of Cardiac Intensive Medicine, Characteristic Medical Center of Chinese People's Armed Police Force, Tianjin 300162, China
4 Institute of Occupational Medicine, Beijing Center for Disease Prevention and Control, Beijing 100020, China