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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Soluble epoxide hydrolase (sEH) is a target enzyme for the treatment of inflammation and cardiovascular disease. A Glycyrrhiza uralensis extract exhibited ~50% inhibition of sEH at 100 μg/mL, and column chromatography yielded compounds 111. Inhibitors 1, 46, 9, and 11 were non-competitive; inhibitors 3, 7, 8, and 10 were competitive. The IC50 value of inhibitor 10 was below 2 μM. Molecular simulation was used to identify the sEH binding site. Glycycoumarin (10) requires further evaluation in cells and animals.

Details

Title
Inhibition of Soluble Epoxide Hydrolase Activity by Components of Glycyrrhiza uralensis
Author
Kim, Jang Hoon 1 ; Yun-Chan, Huh 1 ; Mok Hur 1 ; Park, Woo Tae 1 ; Youn-Ho, Moon 1 ; Tae Il Kim 1 ; Yong Il Kim 1 ; Kim, Seon Mi 1 ; Lee, Jeonghoon 1 ; Lee, Ik Soo 2 

 Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong 27709, Republic of Korea; [email protected] (J.H.K.); 
 Km Covergence Research Division, Korea Institute of Oriental Medicien, Daejeon 34134, Republic of Korea 
First page
6485
Publication year
2023
Publication date
2023
Publisher
MDPI AG
ISSN
16616596
e-ISSN
14220067
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2799717423
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.