Abstract

We aimed to perform superpixel segmentation of ocular blood flow maps obtained using laser speckle flowgraphy (LSFG) and investigate the effects of systemic parameters such as body weight, height, and sex on ocular blood flow resistivity. We studied 757 healthy participants (583 men, 174 women). We calculated the average beat strength over mean blur rate (BOM) as a LSFG resistivity index, as a function of age and sex using ordinary regions of interest (ROI) centered on the optic nerve head (ONH), the retinal vessels region and tissue around the ONH, and the choroid (CHD). We compared the ROI and superpixel-based methods, which are segmented based on image processing, for calculating the BOM. The sex differences in the BOM for the ONH, retinal-vessels region and tissue region of the ONH and CHD were significant for individuals aged ≤ 50 years (P < 0.01) but not those > 50 years old (P > 0.05). The average BOMs calculated using the ROI and superpixel methods were strongly correlated in the ONH (coefficient = 0.87, R2 = 0.8, P < 0.0001, n = 5465). In summary, a superpixel-segmented BOM map is suitable for two-dimensional visualization of ocular blood flow resistivity.

Details

Title
Novel superpixel method to visualize fundus blood flow resistivity in healthy adults
Author
Okamoto, Kenji 1 ; Takahashi, Noriyoshi 1 ; Kobayashi, Tatsuhiko 2 ; Shiba, Tomoaki 3 ; Hori, Yuichi 4 ; Fujii, Hitoshi 5 

 Softcare Co., Ltd., Fukutsu, Japan 
 Toho University, Department of Ophthalmology, School of Medicine, Tokyo, Japan (GRID:grid.265050.4) (ISNI:0000 0000 9290 9879); International University of Health and Welfare Narita Hospital, Department of Ophthalmology, Chiba, Japan (GRID:grid.265050.4) 
 International University of Health and Welfare Narita Hospital, Department of Ophthalmology, Chiba, Japan (GRID:grid.265050.4) 
 Toho University, Department of Ophthalmology, School of Medicine, Tokyo, Japan (GRID:grid.265050.4) (ISNI:0000 0000 9290 9879) 
 Softcare Co., Ltd., Fukutsu, Japan (GRID:grid.265050.4); Kyushu Institute of Technology, Department of Computer Science and Electronics, Iizuka, Japan (GRID:grid.258806.1) (ISNI:0000 0001 2110 1386) 
Pages
6171
Publication year
2023
Publication date
2023
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2801413682
Copyright
© The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.