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Abstract
Evidence has also shown that oxidative stress and systemic inflammation, or in other words, disruption of the oxidant and antioxidant balance, can play an important role in the initiation or progression of NAFLD. The purpose of this study was to investigate the associations between the oxidative balance scores (OBS) and the risk of NAFLD. 552 healthy and 340 patients adult over the age of 18 with NAFLD participated in this case–control research. A validated 168-item quantitative food frequency questionnaire (FFQ) and indicators of physical activity, obesity, and smoking status were used to assess OBS score. The connection between OBS and NAFLD was discovered using binary logistic regression. The mean (± SD) age and (body mass index) BMI of the study population was 40.22 ± 9.79 years and 29.06 ± 3.92 kg/m2, respectively. The mean ± SD of OBS was 41.48 ± 5.23. After adjustment for potential confounders, higher scores of adherence to the OBS conferred a protection for the presence of NAFLD (odds ratio [OR]: 0.29; 95% confidence interval [CI]: 0.15–0.49; P for trend < 0.001). The findings of the present study indicate an approximately 80% reduction in the odds of developing NAFLD with higher OBS adherence in the overall population. However, prospective studies are needed to further investigate this association.
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1 Shahid Beheshti University of Medical Sciences, Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Tehran, Iran (GRID:grid.411600.2)
2 Tehran University of Medical Sciences, Pediatric Gastroenterology and Hepatology Research Center, Pediatrics Centre of Excellence, Children’s Medical Center, Tehran, Iran (GRID:grid.411705.6) (ISNI:0000 0001 0166 0922)
3 Shahid Sadoughi University of Medical Sciences, Department of Nutrition, School of Public Health, Yazd, Iran (GRID:grid.412505.7) (ISNI:0000 0004 0612 5912)
4 National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Sciences, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Tehran, Iran (GRID:grid.419697.4) (ISNI:0000 0000 9489 4252)