1. Introduction
It is estimated that there are between 1.5 and 5 million fungal species on Earth, and about 100,000 species are currently described [1,2]. Of these species, only a few hundred have the capacity to infect humans [3]. Humans are constantly exposed to potential fungal pathogens, as they are part of their normal flora and that of soil, water and air [3]. Moulds are a part of the vast kingdom of fungi alongside yeasts, mushrooms, polypores, plant parasitic rusts and smuts, microsporidia and Pneumocystis. Filamentous fungi are ubiquitous in the environment and can lead to opportunistic diseases presenting as superficial, invasive or disseminated infections. The number of described species is constantly increasing, probably due to the popularisation of DNA-based diagnostic tools, which now allow the distinction between close taxa and the identification of fungi, even in small quantities [1,4]. The taxonomy of fungi is also in constant evolution with the “one fungus, one name” nomenclature and integrative taxonomy approach combining genomics, morphology and ecology [1,5]. In recent years, epidemiological changes in invasive fungal diseases have been observed, new risk factors have emerged, and the number of patients at risk of developing these infections is also increasing [6,7]. Medical mycology is, therefore, a constantly evolving dynamic. Aspergillus, Penicillium, mucorales and dematiaceous fungi are the main filamentous fungi taxa involved in human diseases. Current reviews mainly focused on these taxa [3,8,9]. However, other, rarer species of moulds can emerge in specific infection sites, such as Paecilomyces variotii or Purpureocillium lilacinum in sino-pulmonary fungal infections, and should not be overlooked [10].
In this review, we offer an overview, as of 16 June 2020, of the filamentous fungi identified in humans by culture and nucleotide analyses associated or not with histopathology. We also provide information on the organs where these micromycetes are isolated and on the semiology of the infections. We have chosen to divide our review into two approaches. First, we describe the taxa of interest and indicate their preferred site of infection. We then described which filamentous fungi were involved at each major anatomical site.
2. Materials and Methods
2.1. Systematic Literature Review and Database Creation
First, all fungi names and synonyms were collected on both Mycobank (
An MS Access® database (Access 2013, Microsoft) was set up on 16 June 2020, with these 7428 recorded fungi names. Using this relational database management system, a link for each taxa corresponding to the query described above gave access to the relevant PubMed references and made it possible to study them one by one in order to identify and collect the relevant information.
2.2. Manual Database Incrementation
In the MS Access database (MS Access 2013 TM, Microsoft), each of the 7428 fungi had a record from a page linked to the PubMed-relevant references. For each PubMed reference, an analysis of the title and/or abstract and/or whole paper was performed manually to ensure that it was isolated from humans. This process was time-consuming. Only references present in PubMed before 16 June 2020 were taken into account in order to have the same PubMed content for each fungal species.
After analysis, 6516 fungal taxa that were ultimately not found in humans were excluded. They included fungi of food, therapeutic or environmental interest, or those involved in domesticated animal diseases. Synonyms, when not isolated from humans but associated with a species involved in humans, were also excluded. We focused on non-dermatophytes moulds. In fact, yeasts, microsporidia, dimorphic fungi, dermatophytes and Pneumocystis isolated in humans were also excluded.
We analysed the titles and/or abstracts and/or full paper and/or supplementary data, when available, of 565 moulds fungal names and synonyms isolated in humans to complete information on the anatomical site involved and the semiologies of the associated infection by filling in the PubMed Unique Identifier (PMID) of the publication concerned. Only identifications by direct diagnosis were taken into account, including culture (followed by morphological, Matrix-Assisted Laser Desorption Ionization Time of Flight (MALDI-TOF) mass spectrometry or DNA sequence-based identification) associated or not with histopathological findings and Polymerase Chain Reaction (PCR). Publications reporting a species-level diagnosis based solely on histopathological examination or indirect methods results were excluded. The date of first publication, last publication and the name used was also reported in the software.
The anatomical sites included: systemic (isolated from blood, bone marrow, blood vessels/arteries or lymph nodes), central nervous system (isolated from cerebrospinal fluid or brain biopsy); ophthalmic systems (isolated from ocular samples, such as vitreous humour, corneal scrapings or lacrimal fluid); heart (isolated from cardiac specimens, e.g., valve or pericardial fluid); osteo-articular system (isolated from joint or bone samples); skeletal muscles (isolated from muscles); soft-tissue (isolated from soft-tissue); endocrine glands (isolated from adrenal, pituitary gland or thyroid); skin system (isolated from cutaneous or subcutaneous samples); otorhinolaryngeal sphere (isolated from nasal specimens, including sinuses, and throat specimens, including mouth, tongue, oesophagus, larynx, pharynx or trachea); auditory system (isolated from ear samples); dental (isolated from tooth root, dental pulp or anatomical structures directly in contact with the tooth in case of periodontitis, gingivitis, implant infection or abscess); pulmonary (isolated from the upper respiratory tract, e.g., sputum, lower respiratory tract, bronchoalveolar lavage fluid, lung biopsy, bronchial brushing, bronchoscopic needle aspiration and bronchial aspirate, pleural fluid and mediastinal specimen); breast; urinary tract (isolated from the urinary tract including kidneys, ureters, bladder, urinary meatus and the prostate); genital (isolated from genitalia or related body fluids, both male and female, including penile and urethral samples); digestive system (isolated from stool samples or organs of the digestive system, including peritoneum, intestines, pancreas, spleen, gallbladder or appendix, but excluding the liver); hepatic (liver biopsy); and pregnancy (isolated from the placenta or foetus). When information on the anatomical site was provided, we added a degree of accuracy by specifying anatomical details or semiology of the associated infection (e.g., endophthalmitis for ocular sphere) by filling in the PMIDs. In brief, for each fungus with publications reporting having been identified in humans, the current name and dates of the first and last publications were completed by filling in a list of PMID for each anatomical site and the semiology of the associated infection.
2.3. Data Analysis
The MS Access® database (Access 2013, Microsoft) was converted into two Excel files (Excel 2013, Microsoft). In the first file, the number of PMIDs per taxa was calculated by the anatomical site where the fungi were isolated. In the second, the number of PMIDs per fungus was given for six major fungal categories (i.e., Aspergillus, dematiaceous, Fusarium, mucorales, Penicillium and Pseudallescheria/Scedosporium) according to the infections associated with the isolation of the fungus, as stated by the authors of the article. If more than one case was described in a publication with the same anatomical site, it counted as one publication because of a single PMID.
2.4. Taxonomy
Taxa were organised at the high-level classification into sections or species complexes based on
2.5. Synonyms
We referred to the “current name” in Mycobank to identify the current name and the synonyms. The current name/synonym association was then checked by querying the PubMed database.
2.6. Figures
All figures were produced using the online tool, Wordart (
3. Results
3.1. Fungal Location by Focusing on the Predominant Genus
In total, 6913 articles/PMIDs were included. This bibliographical research identified 565 fungal species of 192 genera, which had been reported at least once in humans. The list of theses taxa is detailed in Table 1, with their former and current scientific name, if applicable. Briefly, there were 204 dematiaceous fungi, 81 Aspergillus spp., 25 Penicillium spp., 35 Fusarium spp., 45 mucorales, 14 of to the Scedosporium/Lomentospora complex, and 161 to other mould species distributed in 103 genera. The results obtained for each of these taxa will be presented below. Regarding the publications reporting the isolation of these micromycetes at all anatomical sites (a publication can be counted multiple times due to the possible report of multiple anatomical sites in the same publication), the leading genus was Aspergillus (total: 4401). The Fumigati and Flavi sections were the most recorded into this genus (total: 2671 and 865, respectively). In second place come the dematiaceous fungi (total: 1976), followed by the Scedosporium/Lomentospora complex (total: 1222), mucorales (total: 1089) and Fusarium (total: 713). Penicillium was rarely reported in human infections (total: 163).
3.1.1. Aspergillus
Aspergillus species were the most frequent moulds isolated in human clinical samples. In this repertoire, the 81 Aspergillus species identified at least once in humans belong to 14 sections of the 20 described [19], as follows: Aspergillus, Candidi, Circumdati, Clavati, Cremei, Flavi, Flavipedes, Fumigati, Nidulantes, Nigri, Polypaecilum, Restricti, Terrei and Usti. As reported in the literature, the filamentous fungus mostly isolated from humans is Aspergillus fumigatus [20], followed by Aspergillus flavus, Aspergillus niger and Aspergillus terreus. The lung and respiratory tracts were the most common anatomical sites of infection, with a total of 1180 publications for A. fumigatus, 174 for A. flavus, 102 for A. niger and 81 publications for A. terreus. These fungi are indeed ubiquitous in the environment and are transmitted by the airways [21]. The results will be approached in terms of the Aspergillus section to rule out potential misidentifications related to morphological identification [4]. The anatomical site in the second position and concerning all the sections was the skin system. Cutaneous aspergillosis can be primary and can affect immunocompetent patients or can be secondary in cases of disseminated infection, predominantly in immunosuppressed patients [22,23,24]. The Nigri section has a tropism for the auditory system, with 79 publications, which has already been noted in the literature [25]. Regarding the clinical presentations involving the central nervous system or heart, the Fumigati section was predominantly represented (194 and 118 publications, respectively). The Fumigati, Flavi and Nigri sections had a predominantly ocular involvement, with 140, 93, and 36 publications, respectively.
3.1.2. Fusarium
The genus Fusarium includes at least 200 species, grouped into about ten phylogenetic species complexes [15,16,26]. In this review of the literature, only eight species complexes were found to have been isolated from humans: F. chlamydosporum species complex (FCSC), F. dimerum species complex (FDSC), F. incarnatum–F. equiseti species complex (FIESC), F. oxysporum species complex (FOSC), F. sambucinum species complex (FSAMSC), F. solani species complex (FSSC), F. fujikuroi species complex (FFSC) and Gibberella fujikuroi species complex (GFSC). Interestingly, looking at the Fusarium genus as a whole, three anatomical sites stand out: the ocular system (190 publications), the cutaneous system (233 publications) and systemic involvement (134 publications). This is consistent with the data in the literature reporting superficial cases, mainly keratitis and onychomycosis in immunocompromised or immunocompromised patients and disseminated infections in immunocompromised patients [27,28,29,30]. Species belonging to the FSSC are predominantly represented, which has previously been shown to be the most virulent Fusarium species complex in animal models [31].
3.1.3. Penicillium
The genus Penicillium is ubiquitous in the environment and is rarely involved in human infections. When found in superficial and aerial samples, they are often considered contaminants. In this literature review, only 163 publications reporting the isolation of these hyaline hyphomycetes in humans were found. One species has emerged since the 1990s and mainly affects humans with acquired immunodeficiency syndrome (AIDS): Talaromyces marneffei [32,33], and this is the predominant species within the genus Penicillium representing 54% of the publications (89/164). The members of the genus Penicillium are mostly reported in three anatomical sites: the pulmonary sphere (48 publications), the cutaneous system (23 publications) and systemic involvement (36 publications).
3.1.4. Mucorales
The order of the mucorales (previously Zygomyces) includes the hyaline pauciseptated filamentous fungi group, comprising 13 genera: Mucor, Lichtheimia, Rhizomucor, Rhizopus, Absidia, Syncephalastrum, Cunninghamella, Apophysomyces, Mycocladus, Saksenaea, Actinomucor, Thamnostylum and Thermomucor. All of these are implicated in human infections [34]. In this literature review, Rhizopus was the genus mostly involved in human infections, with Rhizopus oryzae (121 publications) (plus its synonym and current appellation Rhizopus arrhizus (53 publications)) leading the way, followed by Rhizopus microsporus (90 publications). Mucorales can be classified according to the primary route of infection: airborne, direct contact with contaminated devices or by trauma [34,35]. Here, we compare the number of publications reporting isolation in the skin system versus the respiratory system, including from the oto-rhino-laryngological sphere and pulmonary sphere: The genera Apophysomyces (54 versus 26 publications, respectively), Mucor (40 versus 18 publications, respectively) and Saksenaea (45 versus eight publications, respectively) are mostly isolated from the skin system and therefore transmitted by contact; the genera Cunninghamella (12 versus 52 publications, respectively), Rhizopus (75 versus 134 publications, respectively) and Rhizomucor (8 versus 31 publications, respectively) are mostly isolated from the oto-rhino-laryngological sphere and pulmonary system and are, therefore, airborne; finally, Lichtheimia (77 versus 74 publications, respectively) had a less obvious tropism for one or the other of these two systems. The cutaneous or respiratory tropism can be explained by the differences found in the sporangia of these genera [35]. In fact, the wet spores of the Mucor, Apophysomyces and Saksenaea species are probably not primarily dispersed by the air and transmitted by trauma [35,36]. On the contrary, the sporangiospores of Rhizopus and Rhizomucor species are small (less than 4 µm in diameter), dry and therefore easily airborne [37,38]. This morphological hypothesis does not explain everything because, similar to Mucor, Lichteimia have wet spores and yet they are equivalently reported in the lung and skin in this review.
3.1.5. Dematiaceous moulds
Dematiaceous fungi are also known as “black fungi” due to the predominance of melanin in their cell walls, which likely acts as a virulence factor. These darkly pigmented fungi are found on the soil surface, where they live as saprophytes but also sometimes as parasites of plants [39]. This review has highlighted 204 dematiaceous fungi species isolated from humans, belonging to 19 genera: Alternaria, Exophiala, Cladophialophora, Scopulariopsis, Curvularia, Phialemoniopsis, Phialemonium, Exserohilum, Microascus, Bipolaris, Chaetomium, Cladosporium, Ochroconis, Phaeoacremonium, Rhinocladiella, Fonsecaea, Phialophora, Phoma and Madurella. The genus Exophiala is the most represented. Contamination most often takes place through infection of a wound by a telluric strain or during a transcutaneous traumatism by means of a plant [40]. This explains the predominantly cutaneous location found in this review (1043 publications). Among the cutaneous affections, melanised fungi are responsible for chromoblastomycosis, which mainly affect individuals performing soil-related tasks [41], phaeohyphomycosis [42] and eumycotic myetoma [43]. Two synonyms species stand out for their tropism for the central nervous system, Cladiophialophora bantiana and Cladosporium trichoides, for which 51 publications and 30 publications, respectively, were found in this location.
3.1.6. Pseudallescheria/Scedosporium Species Complex (PSC)
Among the PSC, six genera were represented: Allescheria, Lomentospora, Monosporium, Petriellidium, Pseudallescheria and Scedosporium. These fungi are ubiquitous in the environment and can be found in soil, compost and polluted water [44]. Regarding current nomenclature and taxonomy, the Pseudallescheria/Scedosporium species complex includes the three major species isolated from humans: Scedosporium apiospermum, Scedosporium boydii, and Lomentospora prolificans, and four distinct species, namely Scedosporium aurantiacum (29 publications), Scedosporium dehoogii (2 publications), Scedosporium inflatum (86 publications) and Scedosporium minutisporum (1 publication) [45]. By grouping the publications concerning the main species and their synonyms, we find 468 publications reporting the isolation of Scedosporium apiospermum, 275 publications reporting the isolation of Scedosporium boydii and 261 publications concerning the isolation of Lomentospora prolificans in humans. In regard to locations, S. boydii and S. apiospermum are found in all anatomical sites, with a greater prevalence in the pulmonary sphere (72 and 94 publications, respectively) and the cutaneous system (79 and 110 publications, respectively). Scedosporium prolificans is mainly found in the pulmonary sphere (56 publications) and in systemic infections (52 publications).
3.1.7. Others
Among the moulds not classified in the five major genera, some present in the environment stands out for their ability to affect multiple organs, such as the members of the genus Acremonium, with Acremonium strictum (35 publications) and Acremonium kiliense (27 publications) in the lead, members of the genus Paecilomyces, with Paecilomyces variotii (53 publications), and members of the Trichoderma genus, with Trichoderma longibrachiatum in the lead (40 publications). Others have a cutaneous tropism. Hendersonula toruloidea is an opportunistic fungus which is almost exclusively responsible for skin infections (34/35 publications). Onychocola canadensis is found only on the skin system (17 publications) and is mostly responsible for onychomycosis (16 publications). Finally, some rarely reported species were exclusively found in the ocular area, often secondary to trauma, such as Arthrobotrys oligospora (one publication), Beauveria alba (one publication), Carpoligna pleurothecii (one publication), Cephaliophora irregularis (one publication), Cephalosporium niveolanosum (one publication), Colletotrichum coccodes (one publication), Colletotrichum dematium (seven publications), Edenia gomezpompae (one publication), Epicoccum nigrum (one publication), Glomerella cingulate (one publication), Laetisaria arvalis (one publication), Metarhizium robertsii (one publication), Microcyclosporella mali (one publication), Paecilomyces viridis (one publication), Papulaspora equi (one publication), Pestalotiopsis clavispora (one publication), Phaeoisaria clematidis (one publication), Podospora austroamericana (one publication), Pseudopestalotiopsis theae (one publication), Roussoella solani (one publication), Setosphaeria holmii (one publication), Stachybotrys eucylindrospora (one publication), Tintelnotia destructans (one publication) and Tritirachium roseum (one publication).
3.2. Fungal Location by Focusing on the Anatomical Site
Within the 19 anatomical sites, the semiology of infection was detailed for the six major categories of fungi involved in human pathologies (Table 2).
3.2.1. Systemic
Regarding systemic localisation (comprising fungaemia, aortitis, vasculitis, lymph node infection and bone marrow infection), there is a large majority of fungaemias. The genus Aspergillus was predominantly isolated from blood samples, with Aspergillus fumigatus and Aspergillus flavus predominating (Figure 2). It should be noted that the genus Fusarium was in second place with Fusarium solani. Aspergillus is rarely isolated from blood cultures and is usually in the case of infective endocarditis. This predominance of Aspergillus detection in systemic infections is explained by the use of new detection tools, including PCR.
3.2.2. Central Nervous System
Three genera are mostly represented in central nervous system infections: Aspergillus, dematiaceous fungi and Pseudallescheria/Scedosporium species complex (Figure 3). The majority of infections occur as brain abscesses or meningitis. Figure 2 highlights several species of dematiaceous fungi. Exserohilum rostratum has been involved in iatrogenic meningitis outbreaks secondary to the use of contaminated injectable corticosteroids [46,47,48,49,50,51]. Cladophialophora bantiana is a dematiaceous mould that may infect immunocompetent patients (mainly farmers or residents of agricultural regions), whose reservoirs and modes of transmission are still poorly known [52]. Its neurotropism is highlighted by 51 publications concerning the CNS among a total of 84 in this review. Its synonym, Cladosporium trichoides, causes brain abscesses for which we have recovered 30 publications. Both are responsible for 81 publications reporting CNS involvement.
3.2.3. Ocular System
All categories of fungi can cause ocular damage. Indeed, as filamentous fungi are ubiquitous in the environment, this type of infection is frequently observed during injuries with plants. The genera Aspergillus with Aspergillus fumigatus, Aspergillus flavus, Aspergillus terreus and Aspergillus niger and Fusarium with Fusarium solani and Fusarium oxysporum are predominant (Figure 4). In most cases, it can be keratitis (623 publications) or endophthalmitis (240 publications). The most described species that can cause both keratitis and endophthalmitis are Fusarium solani (85 and 21 publications, respectively), Aspergillus fumigatus (63 and 44 publications, respectively), Aspergillus flavus (52 and 16 publications, respectively), Scedosporium apiospermum (35 and 13 publications, respectively), Aspergillus niger (12 and 13 publications, respectively) and Pseudallescheria boydii (10 and 10 publications, respectively). The other species mostly involved in keratitis are Pythium insidiosum (31 publications), Fusarium oxysporum (21 publications), Lasiodiplodia theobromae (11 publications), Alternaria alternata (10 publications) and Colletotrichum gloeosporioides (10 publications). It should be noted that ten species have been found in conjunctival infections: Aspergillus flavus (one), Aspergillus fumigatus (one), Aspergillus niger (four), Cephalosporium niveolanosum (one), Exophiala jeanselmei (one), Fonsecaea pedrosoi (one), Monosporium apiospermum (one), Neocucurbitaria keratinophila (one), Pseudallescheria boydii (one) and Scedosporium apiospermum (one).
3.2.4. Auditory System
The genus Aspergillus is predominantly isolated from the auditory system, with Aspergillus niger in the lead, a member of the Nigri section known for its tropism for the auditory meatus [25]. Aspergillus flavus and Aspergillus fumigatus come in second place (Figure 5). These fungi are responsible for fungal otomycosis in the majority of cases [53]. Interestingly, 29 publications reported the identification of Pseudallescheria/Scedosporium complex in the auditory system, including 18 reporting otomycosis. Scedosporium apiospermum was predominant, with ten publications reporting otomycosis, including two cases of malignant otitis externa [54,55] and one otitis complicated with temporomandibular arthritis [56]. Other species stand out in Figure 4, such as Absidia corymbifera, of which five publications report the involvement in otomycosis, including one case of malignant otitis externa [57] and a few cases of Penicillium otomycosis (six publications).
3.2.5. Oto-Rhino-Laryngeal System
It is not surprising that a majority of aspergillosis rhinosinusitis is recorded (282 publications) (Figure 6). This anatomical site also includes rhino-orbital, rhino-facial and rhino-orbito-cerebral involvement, which explains the strong representation of mucorales (170 publications). Rhizopus oryzae (heterotypic synonym Rhizopus arrhizus) is largely in the majority of the mucorales (38 publications), which is not surprising, given that it is the most common mucorale species worldwide [58]. Rhizopus oryzae is responsible for variable oto-rhino-laryngeal system infections, with a majority of rhino-orbito-cerebral infections (17 publications) followed by rhino-sinusitis (nine publications) and rhino-orbital involvement (seven publications). These rhino-orbito-cerebral lesions can also be caused by Aspergillus fumigatus (16 publications) and two other species of mucorales Rhizopus arrhizus (12 publications) and Apophysomyces elegans (11 publications). One fungus stands out, Conidiobolus coronatus, which is responsible for entomophthoromycosis and rhino-facial infections. C. coronatus is a widely distributed insect pathogenic fungus belonging to the class Zygomycetes and is rarely involved in human pathology. This mycosis is mainly tropical due to its tropism of plant detritus in very humid environments [59].
3.2.6. Pulmonary System
The respiratory system is the anatomical site most affected by fungal infections (4496 publications). It should be noted that no distinction was made between colonisation and allergic bronchopulmonary aspergillosis, which thus includes the respiratory isolation of Aspergillus species. Similar to Aspergilli, moulds are ubiquitous saprophytes in the environment. Their dispersion in the air is possible by the production of volatile spores, which ensures their presence in both indoor and outdoor environments [60,61]. Human contamination thus mainly occurs by inhaling the airborne conidia, with the lungs being the first to be exposed. We, therefore, note a wide variety of moulds responsible for lung damage (Figure 7).
3.2.7. Cardiac Involvement
Cardiac involvement was found among 13% (74/565) of the species described in this repertoire. These species belonged to the major taxa Aspergillus, Penicillium, Fusarium, mucorales, dematiaceous fungi and Scedosporium/Lomentospora complex, as well as the genera Acremonium sp, Arthrographis sp., Conidiobolus sp., Emericella sp., Engyodontium sp., Paecilomyces sp., Purpureocillium sp., Pythium sp., Rasamsonia sp., Thermothelomyces sp. and Trichoderma sp., with Aspergillus fumigatus being the most common species isolated (Figure 8). These infections are, however, rare with species belonging to the genus Penicillium, including only three publications (one endocarditis due to Penicillium chrysogenum [62] and two pericarditis due to P. citrinum and P. rubens [63,64]) being reported. Cardiac involvement was mainly in the form of endocarditis, whether native (105 publications) or on a prosthetic valve or implanted equipment (96 publications). Interestingly, in native valve endocarditis, mitral involvement seems to be the most frequent (41 publications) (Table 3). Pericarditis and myocarditis were described in 37 and 49 publications, respectively.
3.2.8. Digestive System
Concerning the digestive system, the two main diseases are fungal peritonitis (135 publications) and spleen disease (80 publications) (Figure 9). Micromycetes are known to be responsible for peritonitis during peritoneal dialysis between 1% and 3% of cases, which is indeed the situation we found in the majority of this review [162,163]. In this review, 77.8% of the publications reported peritonitis secondary to peritoneal dialysis (105/135). Other risk factors that emerged were prematurity [164,165,166,167,168] and solid organ transplantation, including the kidney [169,170,171,172,173], heart [174], small bowel [175] and liver [176,177]. Seven publications reported peritoneal involvement secondary to dissemination [174,178,179,180,181,182]. The species mostly found were Aspergillus fumigatus (18 publications), Aspergillus niger (9 publications) and Paecilomyces variotii (8 publications).
Invasive bowel infections by Aspergillus and mucorales (14 and 9 publications, respectively) are mainly reported concomitantly with disseminated infection. Invasion of the gastrointestinal tract is rarely described individually [183].
Splenic involvement was, in the majority of cases, secondary to haematogenous dissemination of the pathogen, with the exception of three situations where splenic abscesses were described. One case of a splenic abscess caused by Aureobasidium pullulans in a patient with lymphoma [184] and one caused by Hortaea werneckii in a patient with acute myeloid leukaemia [185] were both diagnosed postmortem. The third case of splenic abscess caused by Paecilomyces variotii was described in a child with chronic granulomatous disease [186].
3.2.9. Liver Involvement
In terms of hepatic involvement (Figure 10), there is great variability in the forms found, including abscesses, hepatitis, ascites and lesions secondary to hematogenous dissemination (Table 2). The genus Aspergillus is mostly represented (41 publications) with a predominance of Aspergillus fumigatus and Aspergillus flavus.
3.2.10. Urinary Tract
In terms of urinary tract involvement (Figure 11), the vast majority of infections are renal (185 publications), with a predominance of the genus Aspergillus (85 publications). These infections may be primary or secondary to the haematogenous dissemination of the fungus.
3.2.11. Osteo-Articular System
Among the osteoarticular diseases, osteomyelitis is the most frequent (266 publications). The second most common form is joint damage (164 publications), which includes arthritis (57 publications), bursitis (one publication), unspecified joint damage (60 publications) and synovitis (46 publications). Spondylodiscitis comes in third place (71 publications). Among the species involved in these infections are species of the genus Aspergillus (Aspergillus fumigatus, Aspergillus flavus and Aspergillus terreus), the Scedosporium/Lomentospora complex (Pseudallescheria boydii, Scedosporium prolificans and Scedosporium apiospermum) and Fusarium solani (Figure 12).
3.2.12. Skin System
Concerning the involvement of the cutaneous system, four affections stand out: superficial cutaneous infection (1195 publications), subcutaneous infection (610 publications), onychomycosis (394 publications) and mycetoma (282 publications). Aspergillus fumigatus is mostly represented (Figure 13) and is mainly responsible for superficial (84 publications) and subcutaneous (37 publications) infections. The subcutaneous infections are mainly due to dematiaceous fungi (338 publications), with Exophiala jeanselmei coming in first position (47 publications). Melanised fungi are responsible for chronic infections, such as chromoblastomycosis, or phaeohyphomycosis, which can evolve towards an invasive character [43]. Eumycotic mycetoma are subcutaneous infections that we have chosen to put aside, mainly due to the species Madurella mycetomatis (67 publications) and Madurella mycetomi (25 publications). Among the agents mainly responsible for onychomycosis, we found Scopulariopsis brevicaulis (50 publications), Hendersonula toruloidea (28 publications), Fusarium oxysporum (22 publications), Scytalidium dimidiatum (20 publications), Aspergillus niger (18 publications) and Fusarium solani (17 publications). These species are responsible for distal and lateral subungual onychomycosis, the most common type of onychomycosis mainly affecting the toenails [187].
3.2.13. Endocrine Glands
Among the endocrine glands, the thyroid is the most frequently affected (66 publications/84). In the majority of cases, the disease is secondary to systemic dissemination of the pathogen, diagnosed postmortem [188]. In fact, infiltration of the thyroid with Aspergillus organisms occurs in approximately 20% of autopsies in patients dying from a disseminated disease [189]. However, a few rare cases of primary thyroid infections have been reported with Aspergillus fumigatus: two cases of thyroid suppuration in lupus patients treated with corticosteroids [190,191], two cases described in HIV patients [192,193] and one case in a child with chronic granulomatous disease [194]. Scedosporium apiospermum was reported to cause multiple thyroid abscesses in a patient with cirrhosis and autoimmune haemolytic anaemia, presenting swelling in the neck [195].
3.2.14. Rarely Involved Anatomical Sites
Dental location: Endodontic infections were rarely found in this review and manifested themselves in the form of root involvement [196,197], granuloma [198,199] or gingival infections [200,201]. No species seemed to have a particular tropism for this sphere.
Genital sphere: Interestingly, the male genital sphere seems to be mostly affected, with 71.4% of the publications (15/21) reporting testicular, epididymal or glans involvement. Only three publications reported vaginitis [202,203,204], two reported labial involvement [190,205] and one tubo-ovarian abscess [206]. No species seemed to have a particular tropism for this sphere.
Breast: A majority of Aspergillus was isolated from this particular site. It should be noted that the Aspergillus glaucus and Aspergillus niger complexes have already been isolated from milk samples [207,208]. Interestingly, four publications reported fungal infections following breast implant surgery, a situation that is not well-known in this field, due to Aspergillus niger [209,210], Paecilomyces variotii [211] and Scedosporium apiospermum [212].
Placental infection: a single case of placental aspergillosis due to Aspergillus niger was found in this literature review [213].
4. Discussion
The aim of this study was to establish as exhaustive a catalogue as possible of filamentous fungi identified in humans by culture and molecular biology, whether or not they were associated with histopathological findings. We found 565 filamentous fungi identified in humans, for which we specified the organs where these fungi had been found and the semiology of the infections. This repertoire thus helps to understand the pathogenic potential of certain fungi and can also alert clinicians that the isolation of certain rare fungi, such as Trichoderma longibrachiatum (from stool specimens), can lead to disseminated infection. One of the limitations of this work, however, is the lack of distinction between colonisation and infection, mainly for fungi isolated from non-sterile sites (i.e., the cutaneous system, pulmonary system, digestive system and ENT sphere). Fungi isolated from sterile sites were considered infections (i.e., the heart, liver and ocular system and CNS). The use of new powerful molecular tools, such as pan-fungal PCR, metagenomic and next-generation sequencing, now means it is possible to detect pathogens even in samples containing extremely low levels of nucleic acids [214,215] and to diagnose mixed infections [216]. However, the application of these tools to medical mycology can lead to interpretation difficulties [217,218,219]. This problem is particularly encountered with filamentous fungi, which are ubiquitous in the environment and for which it is sometimes difficult to distinguish between colonisation, infection and environmental contamination. It is now necessary to go further in our work for each anatomical site in order to distinguish colonisations from infections, in order to help clinicians interpret positive results and to assist with the diagnostic management of patients. Similarly, we did not distinguish between diagnosis by molecular biology and macroscopic identification, although it has been shown that potential errors were found in macroscopic identifications, mostly between close species within a section or species complex [4]. More, even in molecular identification, it was pointed out that 20% of the sequences available in public databases are unreliable [220,221]. We have based our repertoire according to state of the art at the time of reported publications. Therefore, in Table 1, we have chosen to group species by sections, sharing morphological similarities, in order to bypass this limitation.
Finally, one of the limitations of this publication is its temporality. As explained in Section 2, only references present in PubMed before 16 June 2020 were taken into account in order to have the same PubMed content for all fungi species. However, medical mycology is dynamic, and new organisms constantly need to be accounted for by both clinicians and microbiology laboratories [222]. Moreover, with the COVID-19 pandemic, a new risk factor has emerged [223]. Publications reporting the detection of filamentous fungi in humans have multiplied, reporting, for example, the emergence of mucormycosis and COVID-19-associated pulmonary aspergillosis throughout the world [224,225]. It will therefore be necessary to update this data regularly.
Conceptualization, S.R. and C.L.; methodology, E.M., Q.F. and. J.-C.D.; software, Q.F. and. J.-C.D.; formal analysis, E.M. and C.L.; data curation, E.M.; writing—original draft preparation, E.M., C.L. and J.-C.D.; supervision, S.R. and C.L. All authors have read and agreed to the published version of the manuscript.
The study did not require ethical approval.
Not applicable.
Not applicable.
The authors declare no conflict of interest.
Footnotes
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.
Enlarge this image.Figure 2. Wordcloud represents the species name involved in systemic infections. The size of the name of each species is proportional to the number of times it occurs in the repertoire.
Enlarge this image.Figure 3. Wordcloud represents the species name isolated in the central nervous system. The size of the name of each species is proportional to the number of times it occurs in the repertoire.
Enlarge this image.Figure 4. Wordcloud represents the species name isolated in the ocular system. The size of the name of each species is proportional to the number of times it occurs in the repertoire.
Enlarge this image.Figure 5. Wordcloud represents the species name isolated in the auditory system. The size of the name of each species is proportional to the number of times it occurs in the repertoire.
Enlarge this image.Figure 6. Wordcloud represents the species name isolated in the oto-rhino-laryngeal sphere. The size of the name of each species is proportional to the number of times it occurs in the repertoire.
Enlarge this image.Figure 7. Wordcloud represents the species name isolated in the pulmonary system. The size of the name of each species is proportional to the number of times it occurs in the repertoire.
Enlarge this image.Figure 8. Wordcloud represents the species name isolated in the cardiac system. The size of the name of each species is proportional to the number of times it occurs in the repertoire.
Enlarge this image.Figure 9. Wordcloud represents the species name isolated in the digestive system. The size of the name of each species is proportional to the number of times it occurs in the repertoire.
Enlarge this image.Figure 10. Wordcloud represents the species name isolated in the liver. The size of the name of each species is proportional to the number of times it occurs in the repertoire.
Enlarge this image.Figure 11. Wordcloud represents the species name isolated in the urinary tract. The size of the name of each species is proportional to the number of times it occurs in the repertoire.
Enlarge this image.Figure 12. Wordcloud represents the species name isolated in the osteo-articular system. The size of the name of each species is proportional to the number of times it occurs in the repertoire.
Enlarge this image.Figure 13. Wordcloud represents the species name isolated in the skin system. The size of the name of each species is proportional to the number of times it occurs in the repertoire.
Number of publications found by anatomical site and species. In the same publication (PMID), several anatomical sites of isolation could be found.
| Name | Current Name | Year of 1st Publication | Year of Last Publication | Systemic | CNS | Ocular | Auditory System | Dental and Gums | ORL Sphere | Pulmonary | Breast | Heart | Digestive System | Liver | Urinary Tract | Genital | OA System | Skeletal Muscles | Soft-Tissue | Skin System | Endocrine Gland | Placental Infection | Total |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Aspergillus spp. | 181 | 272 | 300 | 192 | 4 | 528 | 1674 | 6 | 198 | 125 | 41 | 122 | 9 | 233 | 21 | 44 | 415 | 35 | 1 | 4401 | |||
| Section Aspergillus | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 9 | |||||||||||||||
| Aspergillus chevalieri | 1994 | 1994 | 1 | 1 | |||||||||||||||||||
| Aspergillus cibarius | 2014 | 2014 | 1 | 1 | |||||||||||||||||||
| Aspergillus glaucus | 1990 | 2020 | 1 | 1 | 2 | 1 | 1 | 6 | |||||||||||||||
| Aspergillus ruber | 2014 | 2014 | 1 | 1 | |||||||||||||||||||
| Section Candidi | 1 | 1 | 1 | 3 | 6 | 12 | |||||||||||||||||
| Aspergillus candidus | 1962 | 2015 | 1 | 1 | 1 | 3 | 6 | 12 | |||||||||||||||
| Section Circumdati | 1 | 1 | 1 | 2 | 1 | 1 | 4 | 11 | |||||||||||||||
| Aspergillus melleus | 2015 | 2020 | 1 | 1 | 2 | ||||||||||||||||||
| Aspergillus ochraceopetaliformis | 2009 | 2009 | 1 | 1 | |||||||||||||||||||
| Aspergillus ochraceus | 1987 | 2019 | 1 | 2 | 1 | 1 | 5 | ||||||||||||||||
| Aspergillus persii | 2010 | 2010 | 1 | 1 | |||||||||||||||||||
| Aspergillus sclerotiorum | 2004 | 2004 | 1 | 1 | |||||||||||||||||||
| Aspergillus subramanianii | 2018 | 2018 | 1 | 1 | |||||||||||||||||||
| Section Clavati | 1 | 1 | 1 | 2 | 5 | ||||||||||||||||||
| Aspergillus clavatus | 1986 | 2019 | 1 | 1 | 1 | 2 | 5 | ||||||||||||||||
| Section Cremei | 1 | 1 | 2 | ||||||||||||||||||||
| Aspergillus stromatoides | 1987 | 1987 | 1 | 1 | |||||||||||||||||||
| Aspergillus wentii | 2011 | 2011 | 1 | 1 | |||||||||||||||||||
| Section Flavi | 32 | 43 | 93 | 47 | 166 | 190 | 1 | 45 | 22 | 7 | 33 | 1 | 58 | 5 | 14 | 104 | 4 | 865 | |||||
| Aspergillus alliaceus | 2007 | 2010 | 2 | 2 | |||||||||||||||||||
| Aspergillus caelatus | 2019 | 2019 | 1 | 1 | |||||||||||||||||||
| Aspergillus effusus | 2019 | 2019 | 1 | 1 | |||||||||||||||||||
| Aspergillus flavus | 1956 | 2020 | 32 | 41 | 81 | 47 | 162 | 174 | 1 | 44 | 21 | 7 | 33 | 1 | 58 | 5 | 14 | 98 | 4 | 823 | |||
| Aspergillus flavus complex | 2006 | 2020 | 3 | 3 | 6 | ||||||||||||||||||
| Aspergillus minisclerotigenes | 2014 | 2014 | 1 | 1 | |||||||||||||||||||
| Aspergillus nomius | 2009 | 2020 | 1 | 3 | 1 | 5 | |||||||||||||||||
| Aspergillus oryzae | 1976 | 2018 | 2 | 3 | 2 | 5 | 1 | 1 | 14 | ||||||||||||||
| Aspergillus tamarii | 1992 | 2020 | 4 | 1 | 1 | 5 | 11 | ||||||||||||||||
| Aspergillus tanneri | 2012 | 2012 | 1 | 1 | |||||||||||||||||||
| Section Flavipedes | 2 | 1 | 3 | ||||||||||||||||||||
| Aspergillus flavipes | 1979 | 1999 | 2 | 1 | 3 | ||||||||||||||||||
| Section Fumigati | 116 | 194 | 140 | 46 | 1 | 293 | 1225 | 118 | 71 | 30 | 73 | 7 | 133 | 14 | 21 | 161 | 28 | 2671 | |||||
| Aspergillus felis | 2013 | 2019 | 0 | 1 | 4 | 1 | 6 | ||||||||||||||||
| Aspergillus fischeri | 1973 | 1998 | 2 | 2 | |||||||||||||||||||
| Aspergillus fumigatus | 1945 | 2022 | 114 | 190 (191) | 134 (136) | 46 | 1 | 287 | 1180 (1186) | 113 (115) | 67 | 29 | 73 | 7 | 131 | 14 | 21 | 156 | 27 | 2590 (2601) | |||
| Aspergillus fumigates | Aspergillus fumigatus | 2010 | 2020 | 1 | 2 | 6 | 2 | 11 | |||||||||||||||
| Aspergillus fumigatus complex | 2012 | 2020 | 0 | 1 | 1 | 1 | 10 | 1 | 1 | 15 | |||||||||||||
| Aspergillus lentulus | 2006 | 2020 | 14 | 14 | |||||||||||||||||||
| Aspergillus novofumigatus | 2013 | 2013 | 1 | 1 | |||||||||||||||||||
| Aspergillus thermomutatus | 1994 | 2020 | 1 | 1 | 1 | 1 | 1 | 2 | 7 | ||||||||||||||
| Aspergillus udagawae | 2012 | 2017 | 1 | 1 | 2 | ||||||||||||||||||
| Aspergillus viridinutans | 2009 | 2014 | 1 | 1 | 4 | 6 | |||||||||||||||||
| Neosartorya aureola | Aspergillus aureoluteus (anamorph) | 2011 | 2017 | 1 | 1 | ||||||||||||||||||
| Neosartorya fischeri | Aspergillus fischeranus (anamorph) | 1990 | 1997 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 9 | |||||||||||
| Neosartorya hiratsukae | Aspergillus hiratsukae (anamorph) | 2002 | 2010 | 1 | 1 | 2 | 4 | ||||||||||||||||
| Neosartorya laciniosa | Aspergillus laciniosus (anamorph) | 2013 | 2013 | 1 | 1 | ||||||||||||||||||
| Neosartorya udagawae | Aspergillus udagawae (anamorph) | 2009 | 2011 | 1 | 1 | 2 | |||||||||||||||||
| Section Nidulantes | 3 | 12 | 10 | 5 | 1 | 12 | 39 | 1 | 3 | 4 | 4 | 1 | 14 | 2 | 4 | 40 | 155 | ||||||
| Aspergillus amoenus | 2016 | 2016 | 1 | 1 | 2 | ||||||||||||||||||
| Aspergillus creber | 2016 | 2016 | 1 | 1 | 2 | ||||||||||||||||||
| Aspergillus delacroxii | 2015 | 2015 | 1 | 1 | 2 | ||||||||||||||||||
| Aspergillus hongkongensis | 2016 | 2016 | 1 | 1 | |||||||||||||||||||
| Aspergillus nidulans | 1963 | 2021 | 1 | 9 (10) | 3 (4) | 2 | 6 (8) | 20 (23) | 1 | 1 | 1 | 3 | 11 | 2 | 4 | 19 | 83 (90) | ||||||
| Emericella nidulans | Aspergillus nidulans | 1983 | 2016 | 1 | 1 | 2 | 3 | 7 | |||||||||||||||
| Aspergillus nidulans var. echinulatus | Aspergillus delacroxii | 1988 | 1988 | 1 | 1 | 2 | |||||||||||||||||
| Aspergillus protuberus | 2015 | 2019 | 1 | 1 | 1 | 3 | |||||||||||||||||
| Aspergillus quadrilineatus | 1992 | 1992 | 1 | (1) | (4) | 1 (6) | |||||||||||||||||
| Aspergillus tetrazonus | Aspergillus quadrilineatus | 2004 | 2015 | 2 | 2 | ||||||||||||||||||
| Emericella quadrilineata | Aspergillus quadrilineatus | 2004 | 2015 | 1 | 2 | 3 | |||||||||||||||||
| Aspergillus sydowii | 1989 | 2019 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 7 | 16 | ||||||||||||
| Aspergillus sublatus | 2014 | 2019 | 3 | 3 | |||||||||||||||||||
| Aspergillus tabacinus | 2016 | 2016 | 1 | 1 | |||||||||||||||||||
| Aspergillus unguis | 2016 | 2016 | 1 | 1 | |||||||||||||||||||
| Aspergillus versicolor | 1950 | 2021 | 2 | 3 | 2 | 1 | 1 | 5 | 2 | 1 | 5 | 22 | |||||||||||
| Emericella rugulosa | Aspergillus rugulovalvus | 2012 | 2012 | 1 | 1 | 1 | 1 | 4 | |||||||||||||||
| Section Nigri | 17 | 4 | 36 | 79 | 1 | 33 | 113 | 3 | 12 | 12 | 1 | 4 | 9 | 4 | 58 | 1 | 387 | ||||||
| Aspergillus aculeatus | 1984 | 1984 | 1 | 1 | 2 | ||||||||||||||||||
| Aspergillus awamori | 1992 | 2020 | 1 | 1 | 2 | 1 | 5 | ||||||||||||||||
| Aspergillus brasiliensis | 2010 | 2020 | 1 | 1 | 2 | ||||||||||||||||||
| Aspergillus luchuensis | 2010 | 2010 | 1 | 1 | |||||||||||||||||||
| Aspergillus niger | 1965 | 2020 | 14 | 4 | 33 | 72 | 1 | 28 | 102 | 2 | 12 | 10 | 1 | 4 | 8 | 4 | 47 (48) | 1 | 343 (344) | ||||
| Aspergillus foetidus | Aspergillus niger | 1992 | 1992 | 1 | 1 | ||||||||||||||||||
| Aspergillus niger complex | 2002 | 2014 | 1 | 1 | 1 | 3 | |||||||||||||||||
| Aspergillus tubingensis | 2009 | 2020 | 3 | 1 | 5 | 2 | 7 | 1 | 1 | 6 | 26 | ||||||||||||
| Aspergillus uvarum | 2015 | 2015 | 1 | 1 | |||||||||||||||||||
| Aspergillus welwitschiae | 2016 | 2019 | 1 | 1 | 1 | 3 | |||||||||||||||||
| Section Polypaecilum | 1 | 1 | |||||||||||||||||||||
| Polypaecilum insolitum | Aspergillus insolitus | 1972 | 1972 | 1 | 1 | ||||||||||||||||||
| Section Restricti | 1 | 1 | 2 | 4 | 3 | 2 | 1 | 14 | |||||||||||||||
| Aspergillus conicus | 2013 | 2013 | 1 | 1 | |||||||||||||||||||
| Aspergillus gracilis | 2019 | 2019 | 1 | 1 | |||||||||||||||||||
| Aspergillus penicillioides | 2016 | 2018 | 1 | 1 | 1 | 1 | 1 | 1 | 6 | ||||||||||||||
| Aspergillus restrictus | 1960 | 1993 | 1 | 3 | 2 | 6 | |||||||||||||||||
| Section Terrei | 11 | 13 | 15 | 11 | 1 | 16 | 82 | 16 | 11 | 3 | 7 | 16 | 35 | 3 | 240 | ||||||||
| Aspergillus carneus | 2016 | 2016 | 1 | 1 | |||||||||||||||||||
| Aspergillus niveus | 1984 | 2008 | 1 | 1 | 2 | ||||||||||||||||||
| Aspergillus terreus | 1948 | 2021 | 11 | 13 | 15 | 10 | 1 | 16 | 81 | 16 | 10 | 3 | 7 | 16 | 35 | 3 | 237 | ||||||
| Section Usti | 1 | 2 | 1 | 3 | 10 | 1 | 1 | 3 | 22 | ||||||||||||||
| Aspergillus calidoustus | 2008 | 2021 | 1 | 1 | 1 | 3 | 9 | 1 | 1 | 2 | 19 | ||||||||||||
| Aspergillus granulosus | 1995 | 2009 | 1 | 1 | 2 | ||||||||||||||||||
| Aspergillus pseudodeflectus | 2018 | 2018 | 1 | 1 | |||||||||||||||||||
| Unknown Section | 1 | 2 | 1 | 4 | |||||||||||||||||||
| Aspergillus amstelodami | 1983 | 2008 | 1 | 1 | 2 | ||||||||||||||||||
| Aspergillus repens | 1989 | 1989 | 1 | 1 | |||||||||||||||||||
| Eurotium amstelodami | 2016 | 2016 | 1 | 1 | |||||||||||||||||||
| Penicillium spp. | 36 | 3 | 8 | 5 | 1 | 17 | 48 | 1 | 3 | 11 | 2 | 1 | 4 | 23 | 163 | ||||||||
| Section Biverticillata | 1 | 1 | 1 | 3 | |||||||||||||||||||
| Penicillium piceum | 2001 | 2006 | 1 | 1 | 1 | 3 | |||||||||||||||||
| Section Brevicompacta | 1 | 1 | 1 | 3 | |||||||||||||||||||
| Penicillium brevicompactum | 1996 | 2013 | 1 | 1 | 1 | 3 | |||||||||||||||||
| Section Canescentia | 3 | 3 | |||||||||||||||||||||
| Penicillium nigricans | 1992 | 2002 | 3 | 3 | |||||||||||||||||||
| Section Chrysogena | 2 | 2 | 2 | 1 | 5 | 5 | 1 | 2 | 2 | 2 | 24 | ||||||||||||
| Penicillium chrysogenum | 1974 | 2016 | 2 | 1 | 2 | (1) | 3 (4) | 3 (4) | 1 | 2 | 2 | 16 (19) | |||||||||||
| Penicillium notatum | Penicillium chrysogenum | 1978 | 2016 | 1 | 1 | 1 | 3 | ||||||||||||||||
| Penicillium rubens | 2016 | 2020 | 1 | 1 | 1 | 1 | 1 | 5 | |||||||||||||||
| Section Citrina | 5 | 1 | 1 | 3 | 4 | 1 | 15 | ||||||||||||||||
| Penicillium citrinum | 1976 | 2020 | 4 (5) | 1 | (1) | 3 | 4 | 1 | 13 (15) | ||||||||||||||
| Penicillium implicatum | Penicillium citrinum | 2010 | 2010 | 1 | 1 | 2 | |||||||||||||||||
| Section Exilicaulis | 1 | 3 | 4 | ||||||||||||||||||||
| Penicillium corylophilum | 2002 | 2011 | 2 | 2 | |||||||||||||||||||
| Penicillium decumbens | 1990 | 1992 | 1 | 1 | 2 | ||||||||||||||||||
| Section Fasciculata | 1 | 1 | |||||||||||||||||||||
| Penicillium verrucosum | 2001 | 2001 | 1 | 1 | |||||||||||||||||||
| Section Lanata-Divaricata | 1 | 1 | |||||||||||||||||||||
| Penicillium vitale | Penicillium simplicissimum | 1992 | 1992 | 1 | 1 | ||||||||||||||||||
| Section Penicillium | 1 | 1 | 1 | 3 | |||||||||||||||||||
| Penicillium digitatum | 2013 | 2013 | 1 | 1 | |||||||||||||||||||
| Penicillium expansum | 1978 | 2000 | 1 | 1 | 2 | ||||||||||||||||||
| Section Ramigena | 1 | 1 | |||||||||||||||||||||
| Penicillium capsulatum | 2013 | 2013 | 1 | 1 | |||||||||||||||||||
| Section Robsamsonia | 1 | 1 | |||||||||||||||||||||
| Penicillium dipodomyicola | 2013 | 2013 | 1 | 1 | |||||||||||||||||||
| Section Roquefortorum | 1 | 1 | |||||||||||||||||||||
| Penicillium roqueforti | 2018 | 2018 | 1 | 1 | |||||||||||||||||||
| Section Talaromyces | 30 | 1 | 4 | 25 | 5 | 2 | 1 | 3 | 19 | 90 | |||||||||||||
| Talaromyces (Penicillium) marneffei | 2015 | 2020 | 30 | 1 | 4 | 24 | 5 | 2 | 1 | 3 | 19 | 89 | |||||||||||
| Talaromyces purpurogenus | 2016 | 2016 | 1 | 1 | |||||||||||||||||||
| Section Tachyspermi | 1 | 1 | 3 | 1 | 1 | 7 | |||||||||||||||||
| Talaromyces amestolkiae | 2016 | 2017 | 2 | 2 | |||||||||||||||||||
| Talaromyces atroroseus | 2020 | 2020 | 1 | 1 | 1 | 1 | 1 | 5 | |||||||||||||||
| Unclassified into a Section | 1 | 1 | 3 | 1 | 6 | ||||||||||||||||||
| Penicillium lilacinum | 1972 | 1972 | 1 | 1 | |||||||||||||||||||
| Penicillium purpurogenum | 1998 | 1998 | 1 | 1 | |||||||||||||||||||
| Penicillium rugulosum | Talaromyces rugulosus | 1999 | 1999 | 1 | 1 | ||||||||||||||||||
| Talaromyces eburneus | 2010 | 2010 | 1 | 1 | 1 | 3 | |||||||||||||||||
| Fusarium spp. | 134 | 2 | 190 | 1 | 1 | 34 | 41 | 1 | 12 | 17 | 4 | 14 | 1 | 16 | 1 | 4 | 233 | 1 | 713 | ||||
| F. chlamydosporum Species Complex (FCSC) | 1 | 1 | 1 | 1 | 1 | 5 | |||||||||||||||||
| Fusarium chlamydosporum | 1985 | 2020 | 1 | 1 | 1 | 1 | 1 | 5 | |||||||||||||||
| F. dimerum Species Complex (FDSC) | 2 | 7 | 1 | 1 | 1 | 1 | 4 | 17 | |||||||||||||||
| Fusarium dimerum | 1972 | 2018 | 2 | 6 | 1 | 1 | 1 | 1 | 4 | 16 | |||||||||||||
| Fusarium penzigii | 2016 | 2016 | 1 | 1 | |||||||||||||||||||
| F. incarnatum–F. equiseti Species Complex (FIESC) | 1 | 5 | 1 | 1 | 1 | 3 | 12 | ||||||||||||||||
| Fusarium equiseti | 2007 | 2007 | 1 | 1 | |||||||||||||||||||
| Fusarium incarnatum | 2014 | 2020 | 1 | 4 | 1 | 1 | 1 | 3 | 11 | ||||||||||||||
| F. oxysporum Species Complex (FOSC) | 21 | 2 | 24 | 5 | 10 | 3 | 4 | 3 | 3 | 3 | 53 | 131 | |||||||||||
| Fusarium oxysporum | 1958 | 2021 | 21 | 2 | 24 | 5 | 10 | 3 | 4 | 3 | 3 | 3 | 53 | 131 | |||||||||
| F. sambucinum Species Complex (FSAMSC) | 1 | 2 | 3 | ||||||||||||||||||||
| Fusarium roseum | Fusarium sambucinum | 1987 | 1987 | 1 | 1 | ||||||||||||||||||
| Fusarium sporotrichioides | 2017 | 2017 | 1 | 1 | 2 | ||||||||||||||||||
| F. solani Species Complex (FSSC) | 81 | 138 | 20 | 24 | 1 | 6 | 9 | 8 | 1 | 10 | 1 | 3 | 143 | 1 | 452 | ||||||||
| Phialophora cyanescens | Neocosmospora cyanescens | 1984 | 1993 | 1 | 3 | 4 | |||||||||||||||||
| Cephalosporium falciforme | Neocosmospora (fusarium) falciformis | 1968 | 1983 | 2 | 2 | ||||||||||||||||||
| Fusarium keratoplasticum | 2015 | 2019 | 7 | 8 | 2 | 1 | 1 | 1 | 9 | 29 | |||||||||||||
| Fusarium lichenicola | 2003 | 2020 | 3 | 2 | 5 | ||||||||||||||||||
| Fusarium metavorans | 2018 | 2018 | 1 | 1 | |||||||||||||||||||
| Fusarium petroliphilum | 2013 | 2019 | 6 | 2 | 1 | 3 | 12 | ||||||||||||||||
| Fusarium proliferatum | 1988 | 2020 | 6 | 3 | 3 | 2 | 1 | 3 | 1 | 14 | 33 | ||||||||||||
| Fusarium pseudensiforme | Neocosmospora pseudensiformis | 2020 | 2020 | 1 | 1 | ||||||||||||||||||
| Fusarium riograndense | 2018 | 2018 | 1 | 1 | |||||||||||||||||||
| Fusarium solani | 1970 | 2020 | 55 | 5 | 102 | 10 | 15 | 1 | 5 | 8 | 4 | 1 | 7 | 1 | 2 | 94 | 1 | 311 | |||||
| Fusarium solani complex | 2005 | 2019 | 6 | 1 | 18 | 2 | 3 | 1 | 14 | 45 | |||||||||||||
| Neocosmospora tonkinensis | 2018 | 2018 | 1 | 1 | |||||||||||||||||||
| Neocosmospora vasinfecta | Fusarium neocosmosporiellum | 1993 | 2008 | 1 | 1 | 1 | 1 | 1 | 2 | 7 | |||||||||||||
| F. fujikuroi Species Complex (FFSC) | 2 | 1 | 2 | 5 | |||||||||||||||||||
| Fusarium musae | 2015 | 2016 | 2 | 1 | 2 | 5 | |||||||||||||||||
| Gibberella fujikuroi Species Complex (GFSC) | 26 | 12 | 1 | 1 | 6 | 6 | 1 | 3 | 1 | 2 | 3 | 25 | 87 | ||||||||||
| Fusarium acutatum | 2006 | 2015 | 2 | 2 | |||||||||||||||||||
| Fusarium andiyazi | 2014 | 2014 | 1 | 1 | |||||||||||||||||||
| Fusarium moniliforme | 1977 | 2013 | 7 | 6 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 2 | 2 | 11 | 37 | ||||||||
| Fusarium napiforme | 1993 | 2018 | 2 | 2 | 2 | 6 | |||||||||||||||||
| Fusarium nygamai | 1996 | 2015 | 3 | 3 | |||||||||||||||||||
| Fusarium ramigenum | 2016 | 2016 | 1 | 1 | |||||||||||||||||||
| Fusarium sacchari | 2000 | 2020 | 1 | 4 | 1 | 6 | |||||||||||||||||
| Fusarium subglutinans | 2010 | 2013 | 2 | 2 | |||||||||||||||||||
| Fusarium temperatum | 2014 | 2014 | 1 | 1 | |||||||||||||||||||
| Fusarium thapsinum | 2004 | 2004 | 1 | 1 | |||||||||||||||||||
| Fusarium verticillioides | 1995 | 2018 | 11 | 5 | 1 | 1 | 1 | 7 | 26 | ||||||||||||||
| Fusarium verticillioides complex | 2013 | 2013 | 1 | 1 | |||||||||||||||||||
| Unclassified Into Complex | 1 | 1 | |||||||||||||||||||||
| Fusarium langsethiae | 2015 | 2015 | 1 | 1 | |||||||||||||||||||
| Mucorales | 45 | 40 | 18 | 13 | 0 | 164 | 189 | 1 | 26 | 69 | 34 | 50 | 6 | 25 | 24 | 50 | 321 | 14 | 1089 | ||||
| Absidia | 1 | 2 | 3 | ||||||||||||||||||||
| Absidia coerulea | 1988 | 1988 | 2 | 2 | |||||||||||||||||||
| Absidia Lichtheimii | 1968 | 1968 | 1 | 1 | |||||||||||||||||||
| Actinomucor | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 3 | 1 | 13 | |||||||||||||
| Actinomucor elegans | 2001 | 2020 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 3 | 1 | 13 | |||||||||||
| Apophysomyces | 3 | 1 | 1 | 23 | 3 | 1 | 5 | 1 | 14 | 7 | 9 | 19 | 54 | 141 | |||||||||
| Apophysomyces elegans | 1985 | 2020 | 2 | 1 | 1 | 19 | 3 | 1 | 3 | 1 | 12 | 7 | 7 | 12 | 41 | 110 | |||||||
| Apophysomyces trapeziformis | 2012 | 2014 | 1 | 2 | 5 | 4 | 12 | ||||||||||||||||
| Apophysomyces variabilis | 2011 | 2020 | 4 | 2 | 2 | 2 | 9 | 19 | |||||||||||||||
| Cunninghamella | 10 | 4 | 6 | 46 | 9 | 5 | 3 | 3 | 3 | 1 | 3 | 12 | 4 | 109 | |||||||||
| Cunninghamella bertholletiae | 1979 | 2019 | 10 | 4 | 5 | 44 | 9 | 5 | 3 | 3 | 3 | 1 | 3 | 11 | 4 | 105 | |||||||
| Cunninghamella blakesleeana | 2012 | 2012 | 1 | 1 | |||||||||||||||||||
| Cunninghamella echinulata | 2009 | 2013 | 1 | 1 | 1 | 3 | |||||||||||||||||
| Lichtheimia | 14 | 19 | 9 | 9 | 23 | 51 | 9 | 20 | 8 | 13 | 2 | 4 | 3 | 9 | 77 | 6 | 276 | ||||||
| Lichtheimia corymbifera | 1982 | 2019 | 9 (13) | 9 (18) | 4 (8) | 4 (9) | 9 (20) | 22 (43) | 3 (7) | 9 (14) | 3 (6) | 6 (11) | 1 (2) | 3 (4) | 1 (3) | 3 (9) | 37 (67) | 2 (4) | 125 (238) | ||||
| Absidia corymbifera | Lichtheimia corymbifera | 1982 | 2015 | 4 | 8 | 4 | 5 | 11 | 20 | 4 | 5 | 3 | 4 | 1 | 1 | 2 | 6 | 29 | 2 | 109 | |||
| Mycocladus corymbifera | Lichtheimia corymbifera | 2013 | 2013 | 1 | 1 | 1 | 1 | 4 | |||||||||||||||
| Lichtheimia hongkongensis | 2010 | 2010 | 1 | 1 | 1 | 3 | |||||||||||||||||
| Lichtheimia ornata | 2018 | 2020 | 1 | 1 | 2 | ||||||||||||||||||
| Lichtheimia ramosa | 2010 | 2019 | 1 | 1 | 1 | 1 | 8 | 2 | 5 | 2 | 2 | 8 | 2 | 33 | |||||||||
| Mucor | 9 | 1 | 2 | 1 | 11 | 7 | 1 | 10 | 5 | 3 | 1 | 2 | 2 | 40 | 95 | ||||||||
| Mucor circinelloides | 1987 | 2019 | 3 | 1 | 2 | 4 | 1 | 2 | 1 | 2 | 7 | 23 | |||||||||||
| Mucor ellipsoideus | Mucor ardhlaengiktus | 2011 | 2011 | 1 | 1 | ||||||||||||||||||
| Mucor hiemalis | 1986 | 2015 | 1 | 4 | 5 | ||||||||||||||||||
| Mucor indicus | 1990 | 2019 | 2 | 1 | 1 | 1 | 7 | 5 | 1 | 2 | 5 | 25 | |||||||||||
| Mucor irregularis | 2011 | 2019 | 1 | 3 (6) | 1 | 12 (21) | 17 (29) | ||||||||||||||||
| Rhizomucor variabilis | Mucor irregularis | 2009 | 2018 | 3 | 9 | 12 | |||||||||||||||||
| Mucor lusitanicus | 1990 | 1990 | 1 | 1 | |||||||||||||||||||
| Mucor mucedo | 1966 | 2013 | 1 | 1 | 2 | ||||||||||||||||||
| Mucor racemosus | 2011 | 2015 | 1 | 1 | 2 | ||||||||||||||||||
| Mucor ramosissimus | 1993 | 1993 | 1 | 1 | |||||||||||||||||||
| Mucor velutinosus | 2011 | 2018 | 3 | 1 | 1 | 1 | 6 | ||||||||||||||||
| Rhizomucor | 2 | 5 | 10 | 21 | 3 | 4 | 7 | 5 | 1 | 1 | 8 | 2 | 69 | ||||||||||
| Rhizomucor miehei | 1999 | 2017 | 2 | 0 | 1 | 1 | 1 | 5 | |||||||||||||||
| Rhizomucor pusillus | 1983 | 2017 | 2 | 5 | 9 (10) | 18 (19) | 3 | 3 | 6 | 5 | 1 | 1 | 6 (7) | 2 | 61 (64) | ||||||||
| Mucor pusillus | Rhizomucor pusillus | 1952 | 1981 | 1 | 1 | 1 | 3 | ||||||||||||||||
| Rhizopus | 6 | 10 | 4 | 80 | 54 | 1 | 2 | 21 | 9 | 10 | 2 | 6 | 4 | 13 | 75 | 297 | |||||||
| Rhizopus arrhizus | 1975 | 2020 | (3) | 4 (9) | (3) | 19 (57) | 8 (29) | (1) | (2) | (4) | (4) | 1 (4) | (1) | (4) | 2 (3) | 3 (7) | 16 (44) | 53 (175) | |||||
| Rhizopus oryzae | Rhizopus arrhizus | 1955 | 2020 | 3 | 5 | 3 | 38 | 21 | 1 | 2 | 4 | 4 | 3 | 1 | 4 | 1 | 4 | 27 | 121 | ||||
| Rhizopus delemar | Rhizopus arrhizus var. delemar | 2014 | 2014 | 1 | 1 | ||||||||||||||||||
| Rhizopus homothallicus | 2010 | 2019 | 2 | 4 | 0 | 2 | 8 | ||||||||||||||||
| Rhizopus microsporus | 1988 | 2020 | 1 | 1 | 1 | 15 | 19 | 15 (16) | 4 (5) | 5 (6) | 1 | 2 | 1 | 5 | 20 (22) | 90 (95) | |||||||
| Rhizopus azygosporus | Rhizopus microsporus | 1996 | 2005 | 1 | 1 | 1 | 1 | 4 | |||||||||||||||
| Rhizopus oligosporus | Rhizopus microsporus var. oligosporus | 1989 | 1989 | 1 | 1 | ||||||||||||||||||
| Rhizopus rhizopodiformis | Rhizopus microsporus var. rhizopodiformis | 1978 | 2008 | 1 | 3 | 2 | 1 | 6 | 13 | ||||||||||||||
| Rhizopus pusillus | 2019 | 2019 | 1 | 1 | |||||||||||||||||||
| Rhizopus schipperae | 1999 | 1999 | 1 | 1 | 2 | ||||||||||||||||||
| Rhizopus stolonifer | 1996 | 2018 | 1 | 2 | 3 | ||||||||||||||||||
| Saksenaea | 2 | 2 | 6 | 2 | 1 | 1 | 2 | 4 | 6 | 45 | 1 | 72 | |||||||||||
| Saksenaea erythrospora | 2011 | 2018 | 1 | 3 | 4 | 8 | |||||||||||||||||
| Saksenaea vasiformis | 1976 | 2020 | 1 | 2 | 6 | 2 | 1 | 1 | 2 | 4 | 3 | 41 | 1 | 64 | |||||||||
| Syncephalastrum | 2 | 1 | 3 | 6 | 12 | ||||||||||||||||||
| Syncephalastrum racemosum | 2005 | 2020 | 2 | 1 | 3 | 6 | 12 | ||||||||||||||||
| Thamnostylum | 1 | 1 | |||||||||||||||||||||
| Thamnostylum lucknowense | 2012 | 2012 | 1 | 1 | |||||||||||||||||||
| Thermomucor | 1 | 1 | |||||||||||||||||||||
| Thermomucor indicae-seudaticae | 1993 | 1993 | 1 | 1 | |||||||||||||||||||
| Dematiaceous Fungi | 69 | 189 | 160 | 17 | 5 | 127 | 166 | 3 | 28 | 45 | 10 | 14 | 1 | 70 | 8 | 15 | 1043 | 6 | 1976 | ||||
| Alternaria | 1 | 2 | 16 | 1 | 15 | 5 | 4 | 2 | 2 | 2 | 84 | 134 | |||||||||||
| Alternaria alternata | 1976 | 2019 | 1 | 1 | 13 | 13 | 4 | 3 | 1 (2) | 2 | 2 | 40 (41) | 80 (82) | ||||||||||
| Alternaria tenuis | Alternaria alternata | 1960 | 1970 | 1 | 1 | 2 | |||||||||||||||||
| Ulocladium atrum | Alternaria atra | 2006 | 2006 | 1 | 1 | ||||||||||||||||||
| Alternaria chlamydospora | 1990 | 2001 | 4 | 4 | |||||||||||||||||||
| Alternaria dennisii | 2016 | 2016 | 1 | 1 | |||||||||||||||||||
| Alternaria humicola | 1984 | 1985 | 1 | 1 | 2 | ||||||||||||||||||
| Alternaria infectoria | 1998 | 2020 | 1 | 1 | 2 | 1 | 25 | 30 | |||||||||||||||
| Alternaria longipes | 1995 | 1995 | 1 | 1 | |||||||||||||||||||
| Alternaria malorum | 2012 | 2013 | 1 | 1 | |||||||||||||||||||
| Alternaria rosae | 2017 | 2017 | 1 | 1 | |||||||||||||||||||
| Alternaria tenuissima | 1986 | 2020 | 1 | 1 | 8 | 10 | |||||||||||||||||
| Alternaria triticina | 2014 | 2014 | 1 | 1 | |||||||||||||||||||
| Exophiala | 25 | 10 | 19 | 2 | 2 | 9 | 44 | 1 | 3 | 9 | 3 | 1 | 1 | 11 | 1 | 3 | 172 | 1 | 317 | ||||
| Exophiala asiatica | 2009 | 2009 | 1 | 1 | 2 | ||||||||||||||||||
| Exophiala bergeri | 2016 | 2016 | 1 | 1 | |||||||||||||||||||
| Exophiala castellanii | 1994 | 1994 | 1 | 1 | |||||||||||||||||||
| Exophiala dermatitidis | 1984 | 2020 | 17 | 5 | 6 | 1 | 5 | 38 | 1 | 1 | 6 | 3 | 1 | 1 | 2 | 9 | 1 | 97 | |||||
| Exophiala equina | 2013 | 2013 | 1 | 1 | |||||||||||||||||||
| Exophiala hongkongensis | 2013 | 2013 | 1 | 1 | |||||||||||||||||||
| Exophiala jeanselmei | 1981 | 2020 | 3 | 1 (4) | 10 | 2 | 1 | 3 | 1 | 3 | 1 | 3 (4) | 85 (98) | 113 (130) | |||||||||
| Exophiala mansonii | Exophiala jeanselmei var. castellanii | 1986 | 1989 | 1 | 2 | 3 | |||||||||||||||||
| Aureobasidium mansoni | Exophiala jeanselmei var. castellanii | 1989 | 1998 | 3 | 1 | 4 | |||||||||||||||||
| Phialophora gougerotii | Exophiala jeanselmei | 1967 | 1983 | 6 | 6 | ||||||||||||||||||
| Phialophora jeanselmei | Exophiala jeanselmei | 1964 | 1979 | 4 | 4 | ||||||||||||||||||
| Exophiala lecanii-corni | 1994 | 2018 | 5 | 5 | |||||||||||||||||||
| Exophiala moniliae | 1981 | 1984 | 2 | 2 | |||||||||||||||||||
| Exophiala oligosperma | 2003 | 2020 | 1 | 1 | 1 | 2 | 1 | 1 | 16 | 23 | |||||||||||||
| Exophiala phaeomuriformis | 2017 | 2018 | 3 | 3 | |||||||||||||||||||
| Exophiala pisciphila | 1991 | 1991 | 1 | 1 | |||||||||||||||||||
| Exophiala polymorpha | 2015 | 2015 | 1 | 1 | |||||||||||||||||||
| Exophiala salmonis | 2006 | 2012 | 2 | 2 | |||||||||||||||||||
| Exophiala spinifera | 1983 | 2020 | 4 | 1 | 1 | 1 | 4 | 29 | 40 | ||||||||||||||
| Exophiala xenobiotica | 2009 | 2016 | 1 | 6 | 7 | ||||||||||||||||||
| Cladophialophora | 1 | 92 | 2 | 1 | 10 | 1 | 7 | 1 | 75 | 190 | |||||||||||||
| Cladophialophora ajelloi | Cladophialophora carrionii | 1982 | 1982 | 1 | 1 | ||||||||||||||||||
| Cladophialophora arxii | 2009 | 2015 | 1 | 1 | 2 | ||||||||||||||||||
| Cladophialophora bantiana | 1996 | 2020 | 1 | 51 (92) | 1 | 1 | 5 (7) | 5 (6) | 1 | 19 (25) | 84 (134) | ||||||||||||
| Cladosporium trichoides | Cladophialophora bantiana | 1952 | 2020 | 30 | 1 | 6 | 37 | ||||||||||||||||
| Xylohypha bantiana | Cladophialophora bantiana | 1989 | 2013 | 11 | 1 | 1 | 13 | ||||||||||||||||
| Cladophialophora boppii | 2009 | 2020 | 1 | 5 (7) | 6 (8) | ||||||||||||||||||
| Taeniolella boppi | Cladophialophora boppii | 1983 | 1983 | 2 | 2 | ||||||||||||||||||
| Cladophialophora (Cladosporium) carrionii | 1979 | 2021 | 1 | 1 | 1 | 38 | 41 | ||||||||||||||||
| Cladophialophora devriesii | 2006 | 2006 | 1 (3) | 1 (3) | |||||||||||||||||||
| Cladosporium devriesii | Cladophialophora devriesii | 1984 | 1990 | 2 | 2 | ||||||||||||||||||
| Cladophialophora saturnica | 2009 | 2009 | 1 | 1 | |||||||||||||||||||
| Scopulariopsis | 6 | 3 | 7 | 4 | 6 | 16 | 7 | 3 | 1 | 3 | 1 | 1 | 80 | 2 | 140 | ||||||||
| Scopulariopsis acremonium | 1998 | 2009 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 8 | |||||||||||||
| Scopulariopsis alboflavescens | 2018 | 2018 | 1 | 1 | 2 | ||||||||||||||||||
| Scopulariopsis brevicaulis | 1951 | 2020 | 6 | 7 | 4 | 3 | 7 | 5 | 1 | 1 | 1 | 1 | 72 | 108 | |||||||||
| Scopulariopsis brumptii | 1975 | 2017 | 2 | 6 | 1 | 1 | 1 | 1 | 5 | 1 | 18 | ||||||||||||
| Scopulariopsis candida | 1994 | 2015 | 1 | 1 | 2 | 4 | |||||||||||||||||
| Curvularia | 10 | 20 | 1 | 26 | 11 | 1 | 10 | 6 | 2 | 29 | 116 | ||||||||||||
| Curvularia australiensis | 2015 | 2015 | 1 | 1 | |||||||||||||||||||
| Curvularia borreriae | 2013 | 2013 | 1 | 1 | 1 | 1 | 4 | ||||||||||||||||
| Curvularia brachyspora | 1992 | 1997 | 1 | 1 | 2 | ||||||||||||||||||
| Curvularia clavata | 1999 | 2009 | 1 | 1 | 1 | 3 | |||||||||||||||||
| Curvularia geniculata | 1964 | 2014 | 1 | 3 | 1 | 1 | 1 | 2 | 1 | 10 | |||||||||||||
| Drechslera hawaiiensis | Curvularia hawaiiensis | 1973 | 1999 | 2 | 2 | 1 | 2 | 7 | |||||||||||||||
| Curvularia hominis | 2018 | 2018 | 1 | 1 | |||||||||||||||||||
| Curvularia inaequalis | 2005 | 2013 | 2 | 1 | 1 | 4 | |||||||||||||||||
| Curvularia lunata | 1970 | 2019 | 3 | 11 | 13 | 6 | 1 | 4 | 3 | 2 | 20 | 63 | |||||||||||
| Curvularia pallescens | 1977 | 1995 | 1 | 1 | 2 | 4 | |||||||||||||||||
| Curvularia senegalensis | 1991 | 1999 | 1 | 1 | 1 | 3 | |||||||||||||||||
| Curvularia spicifera | 2017 | 2017 | (2) | (1) | 1 (4) | (2) | (1) | (1) | 1 (11) | ||||||||||||||
| Drechslera spicifera | Curvularia spicifera | 1975 | 1988 | 2 | 1 | 3 | 2 | 1 | 1 | 10 | |||||||||||||
| Curvularia tuberculata | 2019 | 2019 | 1 | 1 | 1 | 3 | |||||||||||||||||
| Phialemoniopsis | 2 | 2 | |||||||||||||||||||||
| Phialemoniopsis endophytica | 2017 | 2017 | 1 | 1 | |||||||||||||||||||
| Phialemoniopsis hongkongensis | 2014 | 2014 | 1 | 1 | |||||||||||||||||||
| Phialemonium | 3 | 1 | 2 | 2 | 2 | 1 | 3 | 14 | |||||||||||||||
| Phialemonium dimorphosporum | Phialemonium curvatum | 1993 | 1999 | 1 | 1 | 2 | |||||||||||||||||
| Phialemonium obovatum | 1986 | 2012 | 2 | 1 | 2 | 2 | 2 | 1 | 2 | 12 | |||||||||||||
| Exserohilum | 1 | 10 | 10 | 11 | 1 | 2 | 14 | 49 | |||||||||||||||
| Exserohilum longirostratum | 1994 | 2006 | 1 | 1 | 2 | ||||||||||||||||||
| Exserohilum mcginnisii | 1986 | 2018 | 2 | 1 | 3 | ||||||||||||||||||
| Exserohilum rostratum | 1986 | 2020 | 1 | 10 | 7 | 10 | 1 | 2 | 13 | 44 | |||||||||||||
| Microascus | 1 | 1 | 1 | 8 | 2 | 8 | 21 | ||||||||||||||||
| Microascus cinereus | 1980 | 2013 | 1 | 1 | 2 | 1 | 4 | 9 | |||||||||||||||
| Microascus cirrosus | 1992 | 2018 | 1 | 4 | 1 | 3 | 9 | ||||||||||||||||
| Microascus ennothomasiorum | 2019 | 2019 | 1 | 1 | |||||||||||||||||||
| Microascus trigonosporus | 2004 | 2015 | 2 | 2 | |||||||||||||||||||
| Bipolaris | 5 | 8 | 18 | 1 | 22 | 9 | 1 | 2 | 3 | 2 | 2 | 1 | 15 | 2 | 91 | ||||||||
| Bipolaris australiensis | 1986 | 2017 | 1 | 1 | 3 | 1 | 1 | 1 | 2 | 10 | |||||||||||||
| Bipolaris cynodontis | 2012 | 2015 | 1 | 1 | 1 | 2 | 5 | ||||||||||||||||
| Bipolaris hawaiiensis | 1986 | 2019 | 2 | 8 | 5 | 2 | 1 | 4 | 22 | ||||||||||||||
| Bipolaris oryzae | 2016 | 2016 | 1 | 1 | |||||||||||||||||||
| Bipolaris papendorfii | 2005 | 2005 | 1 | 1 | |||||||||||||||||||
| Bipolaris spicifera | 1984 | 2015 | 4 | 5 | 4 | 1 | 15 | 5 | 1 | 1 | 2 | 2 | 2 | 1 | 7 | 2 | 52 | ||||||
| Chaetomium | 1 | 4 | 2 | 1 | 1 | 6 | 1 | 16 | 32 | ||||||||||||||
| Chaetomium atrobrunneum | 1998 | 2019 | 2 | 1 | 1 | 3 | 7 | ||||||||||||||||
| Chaetomium brasiliense | 2011 | 2011 | 1 | 1 | |||||||||||||||||||
| Chaetomium funicola | 2007 | 2007 | 1 | 1 | |||||||||||||||||||
| Chaetomium globosum | 1988 | 2020 | 1 | 1 | 1 | 4 | 12 | 19 | |||||||||||||||
| Chaetomium homopilatum | Humicola homopilata | 1997 | 1997 | 1 | 1 | ||||||||||||||||||
| Chaetomium perlucidum | 2003 | 2003 | 1 | 1 | 1 | 3 | |||||||||||||||||
| Cladosporium | 1 | 4 | 4 | 2 | 7 | 7 | 1 | 17 | 43 | ||||||||||||||
| Cladosporium bruhnei | Cladosporium allicinum | 1994 | 2014 | 1 | 1 | 1 | 3 | ||||||||||||||||
| Cladosporium castellanii | 2005 | 2005 | 1 | 1 | |||||||||||||||||||
| Cladosporium cladosporioides | 1975 | 2019 | 1 | 3 | 1 | 3 | 6 | 9 | 23 | ||||||||||||||
| Cladosporium herbarum | 1994 | 2012 | 3 | 1 | 4 | ||||||||||||||||||
| Cladosporium langeronii | 2018 | 2018 | 1 | 1 | |||||||||||||||||||
| Cladosporium macrocarpum | 2011 | 2011 | 1 | 1 | |||||||||||||||||||
| Cladosporium oxysporum | 1999 | 2006 | 2 | 2 | |||||||||||||||||||
| Cladosporium sphaerospermum | 2003 | 2019 | 1 | 2 | 1 | 1 | 1 | 2 | 8 | ||||||||||||||
| Ochroconis | 1 | 2 | 1 | 5 | 6 | 1 | 16 | ||||||||||||||||
| Ochroconis constricta | 2014 | 2014 | (1) | (2) | (1) | (3) | 1 | (1) | 1 (9) | ||||||||||||||
| Dactylaria constricta | Ochroconis constricta | 1992 | 2012 | 1 | 2 | 1 | 3 | 1 | 8 | ||||||||||||||
| Ochroconis cordanae | 2014 | 2014 | 1 | 1 | |||||||||||||||||||
| Ochroconis mirabilis | 2014 | 2016 | 1 | 2 | 3 | ||||||||||||||||||
| Ochroconis musae | 2018 | 2018 | 1 | 1 | |||||||||||||||||||
| Ochroconis olivacea | 2014 | 2014 | 1 | 1 | |||||||||||||||||||
| Ochroconis tshawytschae | 2012 | 2012 | 1 | 1 | |||||||||||||||||||
| Phaeoacremonium | 4 | 2 | 3 | 3 | 1 | 6 | 1 | 1 | 29 | 50 | |||||||||||||
| Phaeoacremonium aleophilum | 2003 | 2011 | 2 | 2 | |||||||||||||||||||
| Phaeoacremonium fuscum | 2015 | 2015 | 1 | 1 | |||||||||||||||||||
| Phaeoacremonium inflatipes | 1998 | 2014 | 1 | 1 | 2 | 4 | |||||||||||||||||
| Phaeoacremonium krajdenii | 2006 | 2006 | 1 | 1 | |||||||||||||||||||
| Phaeoacremonium parasiticum (Phialophora parasitica) | 1983 | 2019 | 3 | 2 | 2 | 3 | 1 | 5 | 1 | 1 | 18 | 36 | |||||||||||
| Phaeoacremonium rubrigenum | 1999 | 2012 | 3 | 3 | |||||||||||||||||||
| Phaeoacremonium sphinctrophorum | 2016 | 2016 | 1 | 1 | |||||||||||||||||||
| Phaeoacremonium venezuelense | 2006 | 2012 | 1 | 1 | 2 | ||||||||||||||||||
| Rhinocladiella | 15 | 1 | 2 | 1 | 1 | 8 | 28 | ||||||||||||||||
| Rhinocladiella aquaspersa | 1983 | 2019 | 2 | 4 | 6 | ||||||||||||||||||
| Rhinocladiella atrovirens | 1989 | 1989 | 1 | 1 | |||||||||||||||||||
| Rhinocladiella basitona | 2013 | 2015 | 1 | 1 | 2 | ||||||||||||||||||
| Rhinocladiella mackenziei | 2009 | 2020 | 14 | 1 | 1 | 16 | |||||||||||||||||
| Rhinocladiella similis | 2017 | 2020 | 3 | 3 | |||||||||||||||||||
| Fonsecaea | 1 | 9 | 6 | 3 | 4 | 6 | 1 | 2 | 1 | 147 | 180 | ||||||||||||
| Fonsecaea monomorpha | 2005 | 2019 | 2 | 1 | 10 | 13 | |||||||||||||||||
| Fonsecaea nubica | 2010 | 2020 | 1 | 14 | 15 | ||||||||||||||||||
| Fonsecaea pedrosoi | 1973 | 2020 | 1 | 7 | 5 | 2 | 4 | 5 (6) | 1 | 2 | 1 | 107 (122) | 135 (151) | ||||||||||
| Fonsecaea compactum | Fonsecaea pedrosoi | 1983 | 1989 | 2 | 2 | ||||||||||||||||||
| Fonsecaea compactum/compacta | Fonsecaea pedrosoi | 1983 | 2007 | 5 | 5 | ||||||||||||||||||
| Hormodendrum pedrosoi | Fonsecaea pedrosoi | 1961 | 1978 | 1 | 2 | 3 | |||||||||||||||||
| Phialophora pedrosoi | Fonsecaea pedrosoi | 1951 | 1994 | 6 | 6 | ||||||||||||||||||
| Fonsecaea pugnacius | 2015 | 2015 | 1 | 1 | |||||||||||||||||||
| Phialophora | 8 | 1 | 2 | 1 | 1 | 7 | 1 | 39 | 60 | ||||||||||||||
| Phialophora americana | 2019 | 2019 | 1 | 1 | |||||||||||||||||||
| Phialophora hoffmannii | 1982 | 1982 | 1 | 1 | |||||||||||||||||||
| Phialophora reptans | 2011 | 2011 | 1 | 1 | |||||||||||||||||||
| Phialophora richardsiae | 1968 | 2004 | 1 | 1 | 5 | 1 | 11 | 19 | |||||||||||||||
| Phialophora verrucosa | 1968 | 2019 | 7 | 1 | 2 | 1 | 2 | 25 | 38 | ||||||||||||||
| Phoma | 1 | 1 | 5 | 7 | |||||||||||||||||||
| Phoma exigua | 2006 | 2006 | 1 | 1 | |||||||||||||||||||
| Phoma glomerata | 2008 | 2008 | 1 | 1 | |||||||||||||||||||
| Phoma herbarum | 2010 | 2010 | 1 (2) | 1 (2) | |||||||||||||||||||
| Phoma hibernica | Phoma herbarum | 1970 | 1970 | 1 | 1 | ||||||||||||||||||
| Phoma minutella | 1987 | 1987 | 1 | 1 | |||||||||||||||||||
| Phoma minutispora | Westerdykella minutispora | 1984 | 1984 | 1 | 1 | ||||||||||||||||||
| Phoma sorghina | 1989 | 1989 | 1 | 1 | |||||||||||||||||||
| Madurella | 1 | 2 | 1 | 1 | 15 | 4 | 94 | 118 | |||||||||||||||
| Madurella fahalii | 2012 | 2014 | 2 | 2 | |||||||||||||||||||
| Madurella mycetomatis | 1985 | 2020 | 1 | (2) | 1 | 1 | 13 (15) | 4 | 63 (88) | 83 (112) | |||||||||||||
| Madurella mycetomi | Madurella mycetomatis | 1956 | 2013 | 2 | 2 | 25 | 29 | ||||||||||||||||
| Madurella pseudomycetomatis | 2010 | 2020 | 3 | 3 | |||||||||||||||||||
| Madurella tropicana | 2012 | 2012 | 1 | 1 | |||||||||||||||||||
| Other Genus | 21 | 16 | 42 | 1 | 1 | 20 | 33 | 10 | 14 | 2 | 5 | 10 | 1 | 3 | 200 | 379 | |||||||
| Achaetomium strumarium | 2018 | 2018 | 1 | 1 | |||||||||||||||||||
| Acrophialophora fusispora | 1983 | 2020 | 3 | 5 | 1 | 5 | 14 | ||||||||||||||||
| Acrophialophora levis | 2015 | 2019 | 1 | 2 | 1 | 4 | |||||||||||||||||
| Anthopsis deltoidea | 1984 | 1984 | 1 | 1 | |||||||||||||||||||
| Arnium leporinum | 1984 | 1984 | 1 | 1 | 1 | 3 | |||||||||||||||||
| Arthrinium arundinis | 2017 | 2018 | 4 | 4 | |||||||||||||||||||
| Arthrinium phaeospermum | 1989 | 1989 | 1 | 1 | |||||||||||||||||||
| Ascotricha chartarum | 1996 | 2019 | 1 | 1 | 2 | ||||||||||||||||||
| Aureobasidium melanogenum | 2016 | 2016 | 1 | 1 | |||||||||||||||||||
| Aureobasidium proteae | 2012 | 2012 | 1 | 1 | |||||||||||||||||||
| Aureobasidium pullulans | 1971 | 2019 | 11 | 5 | 1 | 1 | 3 | 6 | 1 | 13 | 41 | ||||||||||||
| Cladorrhinum bulbillosum | 2011 | 2011 | 1 | 1 | |||||||||||||||||||
| Cochliobolus hawaiiensis | 2015 | 2015 | 1 | 1 | |||||||||||||||||||
| Lecythophora hoffmannii | Coniochaeta hoffmannii | 1997 | 1997 | 1 | 1 | ||||||||||||||||||
| Phialophora mutabilis | Coniochaeta mutabilis | 1973 | 1991 | 1 | 2 | 3 | |||||||||||||||||
| Coniochaeta polymorpha | 2013 | 2013 | 1 | 1 | |||||||||||||||||||
| Coniothyrium fuckelii | 1987 | 1987 | 1 | 1 | |||||||||||||||||||
| Corynespora cassiicola | 1969 | 2019 | 1 | 8 | 9 | ||||||||||||||||||
| Cyphellophora pluriseptata | 1986 | 2002 | 2 | 2 | |||||||||||||||||||
| Pseudomicrodochium fusarioides | Cyphellophora fusarioides | 1991 | 1991 | 1 | 1 | ||||||||||||||||||
| Drechslera dematioidea | 2005 | 2005 | 1 | 1 | |||||||||||||||||||
| Drechslera rostrata | 1986 | 1986 | 1 | 1 | |||||||||||||||||||
| Dichotomophthoropsis nymphaearum | 1990 | 1990 | 1 | 1 | |||||||||||||||||||
| Hormonema dematioides | 1990 | 1998 | 1 | 1 | 1 | 3 | |||||||||||||||||
| Hortaea werneckii | 2005 | 2019 | 1 | (1) | 1 | 13 (26) | 15 (29) | ||||||||||||||||
| Cladosporium werneckii | Hortaea werneckii | 1964 | 1978 | 6 | 6 | ||||||||||||||||||
| Exophiala werneckii | Hortaea werneckii | 1980 | 2000 | 1 | 7 | 8 | |||||||||||||||||
| Lasiodiplodia theobromae | 1976 | 2019 | 1 | 12 | 4 | 1 | 3 | 21 | |||||||||||||||
| Lecythophora mutabilis | 1985 | 2011 | 1 | 4 | 2 | 1 | 1 | 9 | |||||||||||||||
| Leptosphaeria senegalensis | 1960 | 2006 | 4 | 4 | |||||||||||||||||||
| Macrophomina phaseolina | 2008 | 2020 | 2 | 1 | 1 | 1 | 5 | ||||||||||||||||
| Microsphaeropsis arundinis | 2004 | 2019 | 2 | 5 | 7 | ||||||||||||||||||
| Microsphaeropsis olivacea | 1999 | 2001 | 1 | 1 | 2 | ||||||||||||||||||
| Mycoleptodiscus indicus | 1995 | 2012 | 2 | 1 | 3 | 6 | |||||||||||||||||
| Neoscytalidium dimidiatum | 2009 | 2019 | (2) | (2) | (1) | 1 (4) | 1 (2) | 17 (46) | 19 (57) | ||||||||||||||
| Scytalidium dimidiatum | Neoscytalidium dimidiatum | 1993 | 2015 | 2 | 2 | 1 | 3 | 1 | 29 | 38 | |||||||||||||
| Neotestudina rosatii | 1968 | 1982 | 3 | 3 | |||||||||||||||||||
| Nigrospora oryzae | 2014 | 2014 | 1 | 1 | |||||||||||||||||||
| Nigrospora sphaerica | 2009 | 2020 | 1 | 2 | 3 | ||||||||||||||||||
| Oidiodendron cerealis | 1969 | 1969 | 1 | 1 | |||||||||||||||||||
| Papulaspora equi | 2014 | 2020 | 2 | 2 | |||||||||||||||||||
| Phaeosclera dematioides | 1987 | 1996 | 1 | 3 | 4 | ||||||||||||||||||
| Phomopsis bougainvilleicola | 2013 | 2013 | 1 | 1 | |||||||||||||||||||
| Phomopsis longicolla | 2011 | 2011 | 1 | 1 | |||||||||||||||||||
| Piedraia hortae | 1978 | 1997 | 4 | 4 | |||||||||||||||||||
| Pleurophomopsis lignicola | 1995 | 2004 | 1 | 3 | 4 | ||||||||||||||||||
| Phialophora repens | Pleurostoma repens | 1975 | 1996 | 3 | 3 | ||||||||||||||||||
| Pleurostomophora richardsiae | 2012 | 2019 | 1 | 1 | 4 | 6 | |||||||||||||||||
| Pseudochaetosphaeronema larense | 1987 | 2014 | 3 | 3 | |||||||||||||||||||
| Pseudochaetosphaeronema martinelli | 2015 | 2015 | 1 | 1 | |||||||||||||||||||
| Phoma cava | Pyrenochaeta cava | 1997 | 1997 | 1 | 1 | ||||||||||||||||||
| Pyrenochaeta unguis-hominis | 1980 | 2020 | 3 | 3 | |||||||||||||||||||
| Scytalidium cuboideum | 2013 | 2013 | 1 | 1 | 2 | ||||||||||||||||||
| Scytalidium hyalinum | 1977 | 2018 | 1 | 21 | 22 | ||||||||||||||||||
| Scytalidium lignicola | 1983 | 2020 | 1 | 4 | 5 | ||||||||||||||||||
| Sphaeropsis subglobosa | 1991 | 1991 | 1 | 1 | |||||||||||||||||||
| Tetraploa aristata | 1990 | 2013 | 1 | 1 | 2 | ||||||||||||||||||
| Thermomyces lanuginosus | 1991 | 1991 | 1 | 1 | |||||||||||||||||||
| Thermothelomyces thermophila | 2017 | 2017 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 7 | |||||||||||||
| Myceliophthora thermophila | Thermothelomyces thermophila | 1992 | 2011 | 2 | 1 | 3 | 3 | 1 | 1 | 1 | 1 | 13 | |||||||||||
| Ulocladium botrytis | 2004 | 2010 | 1 | 1 | 2 | ||||||||||||||||||
| Ulocladium chartarum | 1981 | 2003 | 2 | 2 | |||||||||||||||||||
| Veronaea botryosa | 2003 | 2018 | 0 | 10 | 10 | ||||||||||||||||||
| Verruconis gallopava | 2014 | 2020 | (1) | 1 (7) | (1) | 1 | 1 | 6 (12) | (3) | (1) | (1) | (2) | 1 (5) | 10 (35) | |||||||||
| Dactylaria gallopava | Verruconis gallopava | 1990 | 2001 | 4 | 2 | 1 | 1 | 1 | 1 | 10 | |||||||||||||
| Ochroconis gallopava | Verruconis gallopava | 1986 | 2018 | 1 | 2 | 1 | 4 | 2 | 2 | 3 | 15 | ||||||||||||
| Scedosporium/Lomentospora complex | 98 | 126 | 132 | 27 | 1 | 73 | 253 | 1 | 50 | 35 | 17 | 44 | 3 | 110 | 4 | 21 | 211 | 16 | 1222 | ||||
| Lomentospora prolificans | 2015 | 2020 | 7 (52) | 4 (21) | 4 (17) | (2) | (1) | (11) | 10 (56) | 1 (17) | (13) | (8) | (15) | 4 (25) | (1) | 2 | 2 (18) | (2) | 34 (261) | ||||
| Scedosporium prolificans | Lomentospora prolificans | 1993 | 2017 | 45 | 17 | 13 | 2 | 1 | 11 | 46 | 16 | 13 | 8 | 15 | 21 | 1 | 16 | 2 | 227 | ||||
| Scedosporium apiospermum | 1981 | 2020 | 18 | 40 (43) | 56 (64) | 15 (16) | 25 (27) | 86 (94) | 1 | 13 | 7 | 3 | 6 (8) | 1 | 42 (45) | 1 | 14 | 96 (110) | 3 | 427 (468) | |||
| Monosporium apiospermum | Scedosporium apiospermum | 1953 | 1993 | 3 | 8 | 1 | 2 | 8 | 2 | 3 | 12 | 39 | |||||||||||
| Polycytella hominis | Scedosporium apiospermum | 1987 | 2006 | 2 | 2 | ||||||||||||||||||
| Scedosporium aurantiacum | 2005 | 2019 | 2 | 1 | 3 | 3 | 1 | 14 | 2 | 3 | 29 | ||||||||||||
| Scedosporium boydii | 2014 | 2020 | (13) | 1 (55) | 2 (44) | (5) | (29) | 4 (79) | 1 (15) | (5) | (2) | (14) | (2) | (33) | (2) | 2 (72) | (5) | 10 (375) | |||||
| Allescheria boydii | Scedosporium boydii | 1948 | 1996 | 8 | 9 | 2 | 17 | 2 | 1 | 4 | 12 | 2 | 57 | ||||||||||
| Petriellidium boydii | Scedosporium boydii | 1976 | 1997 | 1 | 7 | 6 | 1 | 5 | 9 | 3 | 1 | 5 | 10 | 48 | |||||||||
| Pseudallescheria angusta | Scedosporium boydii | 2011 | 2019 | 1 | 1 | 2 | |||||||||||||||||
| Pseudallescheria boydii | Scedosporium boydii | 1982 | 2017 | 12 | 39 | 27 | 4 | 22 | 48 | 9 | 5 | 2 | 12 | 2 | 24 | 2 | 47 | 3 | 258 | ||||
| Scedosporium dehoogii | 2017 | 2018 | 2 | 2 | |||||||||||||||||||
| Scedosporium inflatum | 1990 | 2012 | 13 | 6 | 4 | 1 | 5 | 9 | 5 | 10 | 4 | 7 | 5 | 2 | 3 | 6 | 6 | 86 | |||||
| Pseudallescheria minutispora | Scedosporium minutisporum | 2013 | 2013 | 1 | 1 | ||||||||||||||||||
| Others | 66 | 31 | 150 | 5 | 104 | 140 | 2 | 22 | 52 | 10 | 7 | 1 | 16 | 4 | 5 | 254 | 2 | 871 | |||||
| Acremonium atrogriseum | 2000 | 2000 | 1 | 1 | |||||||||||||||||||
| Acremonium implicatum | 2001 | 2012 | 1 | 1 | 2 | ||||||||||||||||||
| Acremonium potronii | 1975 | 2015 | 1 | 1 | 2 | ||||||||||||||||||
| Acremonium sclerotigenum | 2011 | 2014 | 1 | 2 | 3 | ||||||||||||||||||
| Albifimbria verrucaria | 2020 | 2020 | 1 | 1 | 2 | ||||||||||||||||||
| Amesia atrobrunnea | 2019 | 2019 | 1 | 1 | |||||||||||||||||||
| Amylomyces rouxii | 2018 | 2018 | 1 | 1 | |||||||||||||||||||
| Aphanoascus fulvescens | 1970 | 1992 | 3 | 3 | |||||||||||||||||||
| Arachnomyces kanei | 2002 | 2002 | 1 | 1 | |||||||||||||||||||
| Arthrobotrys oligospora | 1990 | 1990 | 1 | 1 | |||||||||||||||||||
| Arthrographis kalrae | 1997 | 2020 | 3 | 2 | 4 | 3 | 3 | 1 | 2 | 3 | 21 | ||||||||||||
| Arthropsis hispanica | 2013 | 2013 | 1 | 1 | 2 | ||||||||||||||||||
| Auxarthron ostraviense | 2013 | 2013 | 1 | 1 | |||||||||||||||||||
| Basidiobolus haptosporus | 1978 | 2020 | 2 | 3 | 1 | 8 | 14 | ||||||||||||||||
| Beauveria bassiana | 1997 | 2016 | 8 | 1 | 2 | 2 | 13 | ||||||||||||||||
| Botryosphaeria dothidea | 2020 | 2020 | 2 | 2 | |||||||||||||||||||
| Carpoligna pleurothecii | 2010 | 2010 | 1 | 1 | |||||||||||||||||||
| Cephaliophora irregularis | 1995 | 1995 | 1 | 1 | |||||||||||||||||||
| Cephalotheca foveolata | 2006 | 2006 | 1 | 1 | |||||||||||||||||||
| Ceratocystis adiposa | 2014 | 2014 | 1 | 1 | |||||||||||||||||||
| Cercospora apii | 1957 | 1957 | 1 | 1 | |||||||||||||||||||
| Chalara ellisii | 1999 | 1999 | 1 | 1 | |||||||||||||||||||
| Neurospora sitophila | Chrysonilia sitophila (Asexual State) | 1997 | 1997 | 1 | 1 | ||||||||||||||||||
| Chrysosporium articulatum | 2015 | 2015 | 1 | 1 | |||||||||||||||||||
| Chrysosporium georgii | 2001 | 2001 | 1 | 1 | |||||||||||||||||||
| Chrysosporium keratinophilum | 2017 | 2017 | 1 | 1 | |||||||||||||||||||
| Chrysosporium parvum | 1973 | 2007 | 1 | 1 | 7 | 1 | 2 | 12 | |||||||||||||||
| Chrysosporium tropicum | 2007 | 2007 | 1 | 1 | |||||||||||||||||||
| Chrysosporium zonatum | 1999 | 2016 | 3 | 1 | 4 | ||||||||||||||||||
| Colletotrichum coccodes | 2015 | 2015 | 1 | 1 | |||||||||||||||||||
| Colletotrichum crassipes | 2001 | 2001 | 1 | 1 | |||||||||||||||||||
| Colletotrichum dematium | 2004 | 2019 | 7 | 7 | |||||||||||||||||||
| Colletotrichum gloeosporioides | 1998 | 2020 | 10 (11) | 1 | 4 | 15 (16) | |||||||||||||||||
| Glomerella cingulata | Colletotrichum gloeosporioides | 1983 | 1983 | 1 | 1 | ||||||||||||||||||
| Colletotrichum siamense | 2019 | 2019 | 1 | 1 | |||||||||||||||||||
| Colletotrichum truncatum | 2011 | 2020 | 3 | 1 | 4 | ||||||||||||||||||
| Conidiobolus coronatus | 1978 | 2021 | 3 | 1 | 47 (57) | 2 | 1 | 1 | 1 | 3 | 1 | 60 (70) | |||||||||||
| Entomophthora coronata | Conidiobolus coronatus | 1965 | 2006 | 10 | 10 | ||||||||||||||||||
| Conidiobolus incongruus | 1983 | 2010 | 1 | 4 | 2 | 1 | 1 | 1 | 3 | 13 | |||||||||||||
| Conidiobolus lamprauges | 2011 | 2011 | 1 | 1 | 1 | 1 | 4 | ||||||||||||||||
| Coniosporium epidermidis | 2008 | 2012 | 3 | 3 | |||||||||||||||||||
| Paecilomyces javanicus | Cordyceps javanica (Teleomorph) | 1984 | 1986 | 1 | 1 | 2 | 4 | ||||||||||||||||
| Paecilomyces farinosus | Cordyceps farinosa | 1994 | 1994 | 1 | 1 | ||||||||||||||||||
| Thielavia sepedonium | Corynascus sepedonium | 1990 | 1990 | 1 | 1 | ||||||||||||||||||
| Cryptendoxyla hypophloia | 2014 | 2014 | 1 | 1 | |||||||||||||||||||
| Cryptostroma corticale | 1962 | 1966 | 2 | 2 | |||||||||||||||||||
| Cylindrocarpon destructans | 1991 | 2011 | 2 | 2 | |||||||||||||||||||
| Cylindrocarpon lichenicola | 1997 | 2012 | 5 | 1 | 1 | 5 | 12 | ||||||||||||||||
| Daldinia eschscholtzii | 2015 | 2015 | 1 | 1 | |||||||||||||||||||
| Diaporthe phaseolorum | 2011 | 2019 | 1 | 2 (3) | 3 (4) | ||||||||||||||||||
| Phomopsis phaseoli | Diaporthe phaseolorum (Teleomorph) | 2011 | 2011 | 1 | 1 | ||||||||||||||||||
| Didymella microchlamydospora | 2019 | 2019 | 1 | 1 | |||||||||||||||||||
| Edenia gomezpompae | 2013 | 2013 | 1 | 1 | |||||||||||||||||||
| Emarellia grisea | 2016 | 2016 | 1 | 1 | |||||||||||||||||||
| Emarellia paragrisea | 2016 | 2016 | 1 | 1 | |||||||||||||||||||
| Emergomyces africanus | 2017 | 2019 | 2 | 3 | 5 | ||||||||||||||||||
| Emergomyces canadensis | 2018 | 2018 | 1 | 1 | 1 | 3 | |||||||||||||||||
| Emergomyces orientalis | 2017 | 2017 | 1 | 1 | 2 | ||||||||||||||||||
| Emergomyces pasteurianus | 2015 | 2020 | 1 | 2 | 1 | 5 | 9 | ||||||||||||||||
| Emmonsia crescens | 1964 | 2012 | 1 | 1 | 17 | 2 | 1 | 22 | |||||||||||||||
| Engyodontium album | 1983 | 2016 | 1 | 1 (2) | 2 | 1 | 5 (6) | ||||||||||||||||
| Beauveria alba | Engyodontium album | 1984 | 1984 | 1 | 1 | ||||||||||||||||||
| Epicoccum nigrum | 1997 | 2020 | 1 | 2 | 3 | ||||||||||||||||||
| Setosphaeria holmii | Exserohilum holmii | 2018 | 2018 | 1 | 1 | ||||||||||||||||||
| Falciformispora senegalensis | 2014 | 2014 | 1 | 1 | |||||||||||||||||||
| Fuscoporia ferrea | 2010 | 2010 | 1 | 1 | |||||||||||||||||||
| Geomyces pannorum | 2003 | 2008 | 3 | 3 | |||||||||||||||||||
| Cephalosporium serrae | Gibellulopsis serrae | 1974 | 1974 | 1 | 1 | ||||||||||||||||||
| Acremonium polychromum | Gliomastix polychroma | 2004 | 2004 | 1 | 1 | ||||||||||||||||||
| Graphium basitruncatum | 2007 | 2017 | 2 | 1 | 3 | ||||||||||||||||||
| Gymnascella dankaliensis | 1989 | 2007 | 2 | 2 | |||||||||||||||||||
| Hongkongmyces pedis | 2014 | 2014 | 1 | 1 | |||||||||||||||||||
| Hormographiella aspergillata | 1996 | 2019 | 3 | 2 | 1 | 11 | 1 | 3 | 21 | ||||||||||||||
| Hypocrea orientalis | 2008 | 2008 | 1 | 1 | |||||||||||||||||||
| Inonotus (Phellinus) tropicalis | 2005 | 2017 | 1 | 1 | 1 | 2 | 5 | ||||||||||||||||
| Isaria farinosa | 2013 | 2013 | 1 (2) | 1 (2) | |||||||||||||||||||
| Paecilomyces fumosoroseus | Isaria fumosorosea | 2015 | 2015 | 1 | 1 | ||||||||||||||||||
| Knufia epidermidis | 2019 | 2019 | 1 | 1 | |||||||||||||||||||
| Laetisaria arvalis | 2018 | 2018 | 1 | 1 | |||||||||||||||||||
| Botryodiplodia theobromae | Lasiodiplodia theobromae | 1975 | 1976 | 1 | 1 | 2 | |||||||||||||||||
| Malbranchea pulchella | 1951 | 1994 | 1 | 1 | 2 | ||||||||||||||||||
| Medicopsis romeroi | 2016 | 2019 | 1 | 1 | 1 | 7 | 10 | ||||||||||||||||
| Metarhizium anisopliae | 1997 | 2017 | 4 | 1 | 5 | ||||||||||||||||||
| Metarhizium pingshaense | 2017 | 2017 | 1 | 1 | |||||||||||||||||||
| Metarhizium robertsii | 2017 | 2017 | 1 | 1 | 2 | ||||||||||||||||||
| Paecilomyces viridis | Metarhizium viride | 1975 | 1975 | 1 | 1 | ||||||||||||||||||
| Microcyclosporella mali | 2015 | 2015 | 1 | 1 | |||||||||||||||||||
| Fusarium nivale | Microdochium nivale | 1966 | 1966 | 1 | 1 | ||||||||||||||||||
| Monascus ruber | 2010 | 2018 | 1 | 1 | 2 | ||||||||||||||||||
| Mycotypha microspora | 2018 | 2018 | 1 | 1 | |||||||||||||||||||
| Myriodontium keratinophilum | 1985 | 1985 | 1 | 1 | |||||||||||||||||||
| Ramichloridium schulzeri | Myrmecridium schulzeri | 1985 | 1985 | 1 | 1 | ||||||||||||||||||
| Nannizziopsis obscura | 2017 | 2017 | 1 | 1 | 1 | 3 | |||||||||||||||||
| Nattrassia mangiferae | 1997 | 2010 | 3 | 4 (5) | 7 (41) | 14 (49) | |||||||||||||||||
| Hendersonula toruloidea | Nattrassia mangiferae | 1970 | 2004 | 1 | 34 | 35 | |||||||||||||||||
| Acremonium falciforme | Neocosmospora falciformis | 1976 | 2019 | 1 | 3 | 2 | 1 | 10 | 17 | ||||||||||||||
| Neocucurbitaria keratinophila | 2019 | 2019 | 2 | 1 | 3 | ||||||||||||||||||
| Nigrograna mackinnonii | 2013 | 2020 | 4 | 4 | |||||||||||||||||||
| Onychocola canadensis | 1994 | 2016 | 17 | 17 | |||||||||||||||||||
| Ophiostoma piceae | 2009 | 2009 | 1 | 1 | 2 | ||||||||||||||||||
| Ovadendron sulphureo-ochraceum | 1995 | 1995 | 1 | 1 | |||||||||||||||||||
| Paecilomyces formosus | 2016 | 2017 | 1 | 1 | 2 | ||||||||||||||||||
| Paecilomyces marquandii | 1979 | 2000 | 2 | 2 | |||||||||||||||||||
| Thermoascus taitungiacus | Paecilomyces taitungiacus (Anamorph) | 2001 | 2001 | 1 | 1 | ||||||||||||||||||
| Paecilomyces variotii | 1981 | 2019 | 6 (7) | 3 | 4 | 2 | 3 | 10 (12) | 1 | 1 (4) | 10 (12) | 2 | 2 | 1 (2) | (1) | 8 (9) | 53 (64) | ||||||
| Paecilomyces varioti | Paecilomyces variotii (Orthographic Variant) | 1971 | 1998 | 1 | 2 | 3 | 2 | 1 | 1 | 1 | 11 | ||||||||||||
| Pallidocercospora crystallina | 2019 | 2019 | 1 | 1 | |||||||||||||||||||
| Parathyridaria percutanea | 2019 | 2019 | 1 | 1 | |||||||||||||||||||
| Pestalotiopsis clavispora | 2013 | 2013 | 1 | 1 | |||||||||||||||||||
| Petromyces alliaceus | 2007 | 2007 | 1 | 1 | 2 | ||||||||||||||||||
| Phaeoisaria clematidis | 2000 | 2000 | 1 | 1 | |||||||||||||||||||
| Phanerochaete chrysosporium | 2014 | 2014 | 1 | 1 | |||||||||||||||||||
| Phanerochaete sordida | 2017 | 2017 | 1 | 1 | |||||||||||||||||||
| Pleurostoma ootheca | 2014 | 2014 | 1 | 1 | |||||||||||||||||||
| Pleurostoma richardsiae | 2017 | 2019 | 1 | 1 | 1 | 0 | 2 | 5 | |||||||||||||||
| Podospora austroamericana | 2018 | 2018 | 1 | 1 | |||||||||||||||||||
| Pseudopestalotiopsis theae | 2019 | 2019 | 1 | 1 | |||||||||||||||||||
| Pseudotaeniolina globosa | 2003 | 2003 | 1 | 1 | |||||||||||||||||||
| Purpureocillium lilacinum | 2011 | 2020 | 1 | 1 | 9 | 3 | 3 | 2 | 9 | 28 | |||||||||||||
| Pythium insidiosum | 1993 | 2021 | 15 | 1 | 36 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 4 | 65 | ||||||||
| Ramichloridium obovoideum | Ramichloridium makenziei | 1988 | 1999 | 3 | 3 | ||||||||||||||||||
| Rasamsonia aegroticola | 2015 | 2017 | 1 | 3 | 1 | 1 | 1 | 1 | 1 | 9 | |||||||||||||
| Rasamsonia argillacea | 2010 | 2018 | 1 | (3) | (1) | 5 (13) | (1) | (1) | 6 (20) | ||||||||||||||
| Geosmithia argillacea | Rasamsonia argillacea | 2010 | 2015 | 3 | 1 | 8 | 1 | 1 | 14 | ||||||||||||||
| Penicillium emersonii | Rasamsonia emersonii | 1999 | 1999 | 1 | 1 | ||||||||||||||||||
| Rasamsonia piperina | 2016 | 2019 | 1 | 1 | 1 | 3 | |||||||||||||||||
| Rhizoctonia solani | 2012 | 2013 | 1 | 1 | 2 | ||||||||||||||||||
| Rhytidhysterium rufulum | 2014 | 2018 | 4 | 4 | |||||||||||||||||||
| Roussoella solani | 2017 | 2017 | 1 | 1 | |||||||||||||||||||
| Sarocladium kiliense | - | - | (5) | (7) | (1) | (2) | (1) | (2) | (2) | (10) | (30) | ||||||||||||
| Acremonium kiliense | Sarocladium kiliense | 1981 | 2017 | 5 | 6 | 1 | 2 | 1 | 2 | 2 | 8 | 27 | |||||||||||
| Cephalosporium madurae | Sarocladium kiliense | 1962 | 1966 | 2 | 2 | ||||||||||||||||||
| Cephalosporium niveolanosum | Sarocladium kiliense | 1960 | 1960 | 1 | 1 | ||||||||||||||||||
| Acremonium strictum | Sarocladium strictum | 1984 | 2015 | 7 | 2 | 1 | 8 | 2 | 3 | 1 | 1 | 1 | 9 | 35 | |||||||||
| Stachybotrys atra | 1999 | 1999 | 3 | 3 | |||||||||||||||||||
| Stachybotrys chlorohalonata | 2021 | 2021 | 1 | 1 | |||||||||||||||||||
| Stachybotrys eucylindrospora | 2014 | 2014 | 1 | 1 | |||||||||||||||||||
| Thermoascus aurantiacus | 1967 | 1967 | 1 | 1 | |||||||||||||||||||
| Thermoascus crustaceus | 2010 | 2019 | 2 | 4 | 6 | ||||||||||||||||||
| Thielavia subthermophila | 2009 | 2011 | 1 | 1 | 2 | ||||||||||||||||||
| Tilletiopsis minor | 1997 | 2018 | 1 | 1 | 1 | 3 | |||||||||||||||||
| Tintelnotia destructans | 2018 | 2019 | 2 | 2 | |||||||||||||||||||
| Toxicocladosporium irritans | 2011 | 2011 | 1 | 1 | |||||||||||||||||||
| Triadelphia pulvinata | 2001 | 2013 | 1 | 1 | 2 | ||||||||||||||||||
| Trichoderma bissettii | 2014 | 2014 | 1 | 1 | 1 | 1 | 4 | ||||||||||||||||
| Trichoderma citrinoviride | 1999 | 2008 | 1 | 1 | 2 | ||||||||||||||||||
| Trichoderma harzianum | 1996 | 2014 | 1 | 1 | 1 | 2 | 3 | 1 | 1 | 10 | |||||||||||||
| Trichoderma longibrachiatum | 1995 | 2019 | 2 | 3 | 2 | 6 | 9 | 4 | 7 | 2 | 5 | 40 | |||||||||||
| Trichoderma orientale | 2014 | 2014 | 1 | 1 | 1 | 1 | 1 | 5 | |||||||||||||||
| Trichoderma pseudokoningii | 1995 | 2000 | 1 | 1 | 1 | 1 | 4 | ||||||||||||||||
| Trichoderma viride | 1976 | 2005 | 2 | 2 | 1 | 5 | |||||||||||||||||
| Tritirachium oryzae | 2010 | 2018 | 4 | 4 | |||||||||||||||||||
| Tritirachium roseum | 1975 | 1975 | 1 | 1 | |||||||||||||||||||
| Truncatella angustata | 2015 | 2015 | 1 | 1 | |||||||||||||||||||
| Stemphylium lanuginosum | Ulocladium lanuginosum | 1983 | 1983 | 1 | 1 | ||||||||||||||||||
| Ustilago echinata | 2016 | 2016 | 1 | 1 | |||||||||||||||||||
| Ustilago esculenta | 1996 | 2007 | 2 | 2 | |||||||||||||||||||
| Valsa sordida | 2006 | 2008 | 2 | 1 | 3 | ||||||||||||||||||
| Westerdykella dispersa | 2014 | 2018 | 1 | 1 | 2 | ||||||||||||||||||
| Xanthothecium peruvianum | 2017 | 2017 | 1 | 1 | |||||||||||||||||||
| Acremonium recifei | Xeneoacremonium recifiei | 1979 | 2010 | 2 | 3 | 5 | |||||||||||||||||
| Xylaria enteroleuca | 2006 | 2006 | 1 | 1 | |||||||||||||||||||
| Total | - | - | - | 629 | 669 | 958 | 259 | 12 | 1046 | 2511 | 14 | 333 | 354 | 118 | 252 | 21 | 474 | 62 | 139 | 2499 | 74 | 1 | 10,435 |
CNS: central nervous system; ORL: oto-rhino-laryngological; OA: osteo-articular; and (nb): number of publications corresponding to all isolates from the same species on the basis of their current taxonomic.
Anatomical sites and nosological framework of the different taxa. CNS: central nervous system; and ORL: oto-rhino-laryngological. The numbers in the table correspond to PMIDs.
| Aspergillus | Dematiaceous | Pseudallescheria/Scedosporium | Other | Mucorales | Fusarium | Penicillium | Total | |
|---|---|---|---|---|---|---|---|---|
| Systemic | 193 | 75 | 105 | 56 | 46 | 138 | 54 | 678 |
| Anatomical site | ||||||||
| Unspecified | 19 | 8 | 18 | 2 | 47 | |||
| Blood | 91 | 49 | 78 | 24 | 13 | 128 | 31 | 427 |
| Bone marrow | 5 | 1 | 2 | 4 | 13 | 25 | ||
| Lymph nodes | 17 | 15 | 7 | 6 | 2 | 2 | 10 | 57 |
| Semiology | ||||||||
| Aortitis | 29 | 6 | 6 | 1 | 1 | 1 | 44 | |
| Vasculitis | 32 | 4 | 4 | 21 | 12 | 5 | 78 | |
| CNS | 288 | 205 | 133 | 38 | 41 | 8 | 3 | 710 |
| Anatomical site | ||||||||
| Unspecified | 127 | 39 | 46 | 16 | 25 | 2 | 2 | 255 |
| Specimen | ||||||||
| Brain abscess | 79 | 114 | 59 | 13 | 8 | 3 | 273 | |
| Semiology | ||||||||
| Encephalitis | 1 | 4 | 1 | 1 | 6 | |||
| Mass | 37 | 19 | 3 | 4 | 5 | 67 | ||
| Meningitis | 39 | 25 | 17 | 3 | 3 | 3 | 1 | 93 |
| Meningo-encephalitis | 5 | 4 | 7 | 1 | 16 | |||
| Ocular | 321 | 168 | 147 | 155 | 20 | 207 | 9 | 1021 |
| Anatomical site | ||||||||
| Unspecified | 42 | 9 | 28 | 7 | 2 | 4 | 1 | 94 |
| Conjonctival | 6 | 2 | 3 | 2 | 13 | |||
| Orbital | 20 | 2 | 8 | 5 | 3 | 1 | 38 | |
| Specimen | ||||||||
| Lacrimal fluid | 3 | 2 | 1 | 1 | 7 | |||
| Semiology | ||||||||
| Blepharitis | 1 | 1 | ||||||
| Endophthalmitis | 87 | 39 | 43 | 19 | 4 | 41 | 3 | 240 |
| Granuloma | 5 | 5 | ||||||
| Keratitis | 157 | 116 | 63 | 121 | 10 | 161 | 5 | 623 |
| Auditory system | 193 | 17 | 29 | 8 | 13 | 1 | 6 | 263 |
| Anatomical site | ||||||||
| Unspecified | 17 | 8 | 10 | 1 | 3 | 38 | ||
| Semiology | ||||||||
| Implant-associated otomycosis | 1 | 1 | 1 | 3 | ||||
| Otomycosis | 176 | 8 | 18 | 7 | 9 | 1 | 6 | 222 |
| Dental and gums | 5 | 5 | 1 | 1 | 1 | 13 | ||
| Anatomical site | ||||||||
| Unspecified | 4 | 4 | 1 | 1 | 10 | |||
| Specimen | ||||||||
| Abscess | 1 | 1 | 2 | |||||
| Semiology | ||||||||
| Peridontitis | 1 | 1 | ||||||
| ORL sphere | 658 | 153 | 87 | 133 | 179 | 38 | 22 | 1246 |
| Anatomical site | ||||||||
| Unspecified | 5 | 1 | 1 | 1 | 1 | 9 | ||
| Cervical lymphadenopathy | 1 | 1 | ||||||
| Laryngeal | 18 | 1 | 1 | 2 | 22 | |||
| Nasal | 81 | 23 | 5 | 11 | 7 | 8 | 4 | 139 |
| Oesophagus | 7 | 3 | 3 | 1 | 1 | 4 | 2 | 22 |
| Oral mucosa | 20 | 7 | 2 | 3 | 5 | 2 | 39 | |
| Rhinitis | 1 | 1 | ||||||
| Rhino-facial | 1 | 3 | 1 | 47 | 9 | 60 | ||
| Rhino-orbital | 51 | 8 | 6 | 11 | 33 | 105 | ||
| Rhino-orbito-cerebral | 20 | 1 | 9 | 64 | 89 | |||
| Rhino-sinusal | 282 | 87 | 51 | 38 | 41 | 17 | 8 | 514 |
| Sino-oral | 11 | 3 | 3 | 8 | 1 | 26 | ||
| Tongue | 7 | 1 | 9 | |||||
| Tonsil | 1 | 1 | ||||||
| Tracheal | 103 | 6 | 10 | 5 | 9 | 3 | 1 | 135 |
| Semiology | ||||||||
| Fungus ball | 44 | 8 | 7 | 4 | 2 | 1 | 62 | |
| Pharyngeal abscess | 3 | 3 | ||||||
| Pharyngitis | 4 | 2 | 3 | 9 | ||||
| Pulmonary | 3088 | 238 | 424 | 218 | 292 | 51 | 65 | 4353 |
| Anatomical site | ||||||||
| Unspecified | 208 | 13 | 25 | 13 | 21 | 9 | 287 | |
| Lower respiratory tract | 999 | 100 | 166 | 93 | 121 | 20 | 22 | 1509 |
| Lymph nodes | 84 | 13 | 8 | 13 | 21 | 1 | 2 | 141 |
| Mediastinum | 37 | 2 | 2 | 3 | 4 | 48 | ||
| Parenchymal cavity | 331 | 12 | 46 | 8 | 28 | 1 | 6 | 430 |
| PleurisyPleura | 74 | 11 | 13 | 8 | 11 | 1 | 5 | 125 |
| Upper respiratory tract | 694 | 48 | 111 | 34 | 31 | 8 | 12 | 934 |
| Specimen | ||||||||
| Abscess | 40 | 3 | 13 | 6 | 2 | 1 | 63 | |
| Semiology | ||||||||
| Hypersensitivity/Allergy | 106 | 8 | 3 | 1 | 3 | 120 | ||
| Invasive | 389 | 9 | 12 | 14 | 28 | 1 | 9 | 462 |
| Pneumonia | 126 | 19 | 28 | 23 | 25 | 8 | 6 | 234 |
| Breast | 7 | 3 | 1 | 2 | 1 | 1 | 1 | 16 |
| Anatomical site | ||||||||
| Unspecified | 1 | 3 | 1 | 1 | 1 | 7 | ||
| Breast implant | 2 | 1 | 1 | 4 | ||||
| Nipples | 1 | 1 | ||||||
| Specimen | ||||||||
| Milk | 3 | 1 | 4 | |||||
| Heart | 219 | 31 | 54 | 24 | 29 | 13 | 3 | 372 |
| Anatomical site | ||||||||
| Unspecified | 37 | 4 | 11 | 1 | 16 | 4 | 74 | |
| Myocardium | 30 | 3 | 9 | 2 | 4 | 2 | 49 | |
| Pericardium | 23 | 3 | 3 | 5 | 2 | 2 | 37 | |
| Thrombus | 8 | 2 | 1 | 11 | ||||
| Semiology | ||||||||
| Implanted device endocarditis | 55 | 14 | 12 | 10 | 2 | 1 | 96 | |
| Native valve endocarditis | 66 | 7 | 17 | 6 | 6 | 5 | 105 | |
| Digestive | 149 | 49 | 43 | 54 | 94 | 22 | 12 | 422 |
| Anatomical site | ||||||||
| Unspecified | 9 | 2 | 4 | 4 | 13 | 1 | 3 | 36 |
| Appendix | 1 | 2 | 3 | 6 | ||||
| Biliary tract | 6 | 3 | 2 | 11 | ||||
| Bowel | 14 | 1 | 3 | 5 | 9 | 1 | 3 | 36 |
| Gastric | 10 | 1 | 1 | 5 | 15 | 1 | 34 | |
| Pancreas | 7 | 3 | 3 | 1 | 14 | |||
| Peritoneum | 43 | 32 | 7 | 27 | 16 | 8 | 1 | 135 |
| Spleen | 33 | 5 | 15 | 3 | 18 | 6 | 1 | 80 |
| Specimen | ||||||||
| Abscess | 2 | 1 | 1 | 1 | 5 | |||
| Faecal specimen | 15 | 4 | 5 | 6 | 6 | 3 | 4 | 43 |
| Semiology | ||||||||
| Colitis | 2 | 2 | 1 | 5 | ||||
| Enteritis | 2 | 1 | 6 | 9 | ||||
| Mucosal necrosis | 5 | 1 | 3 | 1 | 10 | |||
| Liver | 43 | 10 | 17 | 11 | 34 | 4 | 2 | 120 |
| Anatomical site | ||||||||
| Unspecified | 27 | 8 | 17 | 10 | 23 | 3 | 2 | 89 |
| Specimen | ||||||||
| Abscess | 11 | 1 | 1 | 11 | 0 | 24 | ||
| Ascites fluid | 3 | 1 | 1 | 5 | ||||
| Semiology | ||||||||
| Hepatitis | 2 | 2 | ||||||
| Urinary tract | 159 | 16 | 51 | 14 | 61 | 16 | 1 | 314 |
| Anatomical site | ||||||||
| Unspecified | 3 | 3 | ||||||
| Bladder | 6 | 1 | 4 | 11 | ||||
| Kidney | 86 | 10 | 30 | 9 | 46 | 7 | 1 | 185 |
| Prostate gland | 7 | 1 | 1 | 1 | 10 | |||
| Specimen | ||||||||
| Urine | 28 | 3 | 13 | 2 | 7 | 8 | 62 | |
| Semiology | ||||||||
| Mass | 26 | 2 | 1 | 29 | ||||
| Pyelonephritis | 2 | 1 | 2 | 3 | 2 | 9 | ||
| Urinary tract infection | 1 | 3 | 1 | 5 | ||||
| Genital | 9 | 1 | 3 | 1 | 6 | 1 | 21 | |
| Anatomical site | ||||||||
| Unspecified | 3 | 3 | ||||||
| Epididymis | 1 | 1 | ||||||
| External genitalia | 3 | 1 | 4 | |||||
| Glans | 1 | 3 | 1 | 5 | ||||
| Ovaries | 1 | 1 | ||||||
| Testis | 4 | 4 | ||||||
| Vaginal mucosa | 1 | 1 | 1 | 3 | ||||
| Osteo-articular system | 287 | 84 | 151 | 22 | 28 | 19 | 4 | 589 |
| Anatomical site | ||||||||
| Unspecified | 38 | 9 | 18 | 4 | 9 | 2 | 79 | |
| Joint | 26 | 8 | 21 | 1 | 4 | 1 | 60 | |
| Specimen | ||||||||
| Synovial fluid | 8 | 13 | 20 | 1 | 1 | 4 | 46 | |
| Semiology | ||||||||
| Arthritis | 6 | 13 | 28 | 3 | 2 | 6 | 57 | |
| Bursitis | 1 | 1 | ||||||
| Mass (including mycetoma) | 6 | 3 | 9 | |||||
| Osteomyelitis | 147 | 35 | 55 | 12 | 11 | 5 | 4 | 266 |
| Spondylodiscitis | 56 | 2 | 9 | 1 | 1 | 1 | 71 | |
| Skeletal muscles | 21 | 8 | 4 | 8 | 23 | 1 | 61 | |
| Anatomical site | ||||||||
| Unspecified | 21 | 8 | 4 | 8 | 23 | 1 | 61 | |
| Soft-tissue | 44 | 13 | 21 | 12 | 50 | 4 | 137 | |
| Anatomical site | ||||||||
| Unspecified | 44 | 13 | 21 | 12 | 50 | 4 | 137 | |
| Skin system | 457 | 1154 | 239 | 361 | 376 | 270 | 23 | 2801 |
| Anatomical site | ||||||||
| Unspecified | 43 | 76 | 17 | 5 | 26 | 5 | 173 | |
| Nails | 93 | 156 | 3 | 77 | 3 | 65 | 1 | 394 |
| Subcutaneous | 56 | 343 | 47 | 78 | 84 | 25 | 610 | |
| Superficial cutaneous | 215 | 370 | 91 | 149 | 248 | 139 | 21 | 1195 |
| Semiology | ||||||||
| Dermatitis | 1 | 2 | 1 | 1 | 1 | 1 | 7 | |
| Intertrigos | 1 | 1 | ||||||
| Mycetoma | 15 | 155 | 64 | 46 | 16 | 282 | ||
| Tinea capitis | 1 | 1 | 2 | |||||
| Tinea corporis | 1 | 3 | 4 | |||||
| Tinea manuum | 3 | 3 | ||||||
| Tinea pedis | 8 | 1 | 9 | |||||
| Ulcer | 33 | 39 | 17 | 1 | 14 | 18 | 121 | |
| Endocrine gland | 40 | 7 | 18 | 4 | 15 | 2 | 84 | |
| Anatomical site | ||||||||
| Unspecified | 1 | 2 | 3 | |||||
| Adrenal | 7 | 2 | 3 | 1 | 13 | |||
| Parathyroid | 1 | 1 | ||||||
| Thymus | 1 | 1 | ||||||
| Thyroid | 32 | 4 | 16 | 4 | 11 | 1 | 66 | |
| Placental infection | 1 | 1 | ||||||
| Anatomical site | ||||||||
| Placenta | 1 | 1 | ||||||
| Total | 6182 | 2237 | 1528 | 1121 | 1308 | 797 | 206 | 13,222 |
Details of cardiac sites affected by native valve endocarditis and associated species.
| Current Name | Tricuspid Valve | Mitral Valve | Aortic Valve | All 4 Chambers | Mural Endocardiumm | Pulmonary Valve | Atrium | Ventricle | ND |
|---|---|---|---|---|---|---|---|---|---|
| Absidia corymbifera | 1 [ |
||||||||
| Arnium leporinum | 1 [ |
||||||||
| Arthrographis kalrae | 1 [ |
||||||||
| Aspergillus clavatus | 1 [ |
||||||||
| Aspergillus flavus | 6 [ |
9 [ |
2 [ |
||||||
| Aspergillus fumigatus | 4 [ |
18 [ |
10 [ |
2 [ |
2 [ |
2 [ |
3 [ |
2 [ |
|
| Aspergillus nidulans | 1 [ |
||||||||
| Aspergillus niger | 1 [ |
||||||||
| Aspergillus terreus | 1 [ |
2 [ |
1 [ |
1 [ |
1 [ |
1 [ |
|||
| Aspergillus udagawae | 1 [ |
||||||||
| Cunninghamella bertholletiae | 1 [ |
1 [ |
|||||||
| Engyodontium album | 1 [ |
||||||||
| Exophiala dermatitidis | 1 [ |
||||||||
| Fusarium incarnatum | 1 [ |
||||||||
| Fusarium solani | 1 [ |
1 [ |
1 [ |
||||||
| Fusarium solani complex | 1 [ |
||||||||
| Lomentospora prolificans | 1 [ |
||||||||
| Myceliophthora thermophila | 1 [ |
1 [ |
|||||||
| Paecilomyces javanicus | 1 [ |
||||||||
| Phaeoacremonium parasiticum | 1 [ |
1 [ |
1 [ |
||||||
| Phialemonium obovatum | 1 [ |
1 [ |
|||||||
| Pseudallescheria boydii | 1 [ |
3 [ |
1 [ |
||||||
| Saksenaea vasiformis | 1 [ |
||||||||
| Scedosporium apiospermum | 1 [ |
||||||||
| Scedosporium boydii | 1 [ |
||||||||
| Scedosporium inflatum | |||||||||
| Scedosporium prolificans | 1 [ |
2 [ |
2 [ |
1 [ |
|||||
| Trichoderma longibrachiatum | 1 [ |
||||||||
| Total | 16 | 41 | 24 | 3 | 3 | 4 | 7 | 1 | 8 |
ND: not determined.
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; Dufour, Jean-Charles 3
; Ranque, Stéphane 1
; Coralie L’Ollivier 1
1 Laboratoire de Parasitologie-Mycologie, IHU Méditerranée Infection, 13385 Marseille, France; Institut de Recherche pour le Développement, Assistance Publique-Hôpitaux de Marseille, Service de Santé des Armées, VITROME: Vecteurs-Infections Tropicales et Méditerra-néennes, Aix Marseille Université, 13385 Marseille, France
2 INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l’Information Médicale, ISSPAM, Aix Marseille University, 13385 Marseille, France
3 INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l’Information Médicale, ISSPAM, Aix Marseille University, 13385 Marseille, France; APHM, Hôpital de la Timone, Service Biostatistique et Technologies de l’Information et de la Communication, 13385 Marseille, France