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Abstract
Recent experimental and observational research has suggested that childhood allergic asthma and other conditions may be the result of prenatal exposure to environmental contaminants, such as di-(2-ethylhexyl) phthalate (DEHP). In a previous epidemiological study, we found that ancestral exposure (F0 generation) to endocrine disruptors or the common plasticizer DEHP promoted allergic airway inflammation via transgenerational transmission in mice from generation F1 to F4. In the current study, we employed a MethylationEPIC Beadchip microarray to examine global DNA methylation in the human placenta as a function of maternal exposure to DEHP during pregnancy. Interestingly, global DNA hypomethylation was observed in placental DNA following exposure to DEHP at high concentrations. Bioinformatic analysis confirmed that DNA methylation affected genes related to neurological disorders, such as autism and dementia. These results suggest that maternal exposure to DEHP may predispose offspring to neurological diseases. Given the small sample size in this study, the potential role of DNA methylation as a biomarker to assess the risk of these diseases deserves further investigation.
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1 National Chung Cheng University, Department of Biomedical Sciences, Chia-Yi, Taiwan (GRID:grid.412047.4) (ISNI:0000 0004 0532 3650); National Chung Cheng University, Epigenomics and Human Disease Research Center, Chia-Yi, Taiwan (GRID:grid.412047.4) (ISNI:0000 0004 0532 3650); National Chung Cheng University, Center for Innovative Research on Aging Society (CIRAS), Chia-Yi, Taiwan (GRID:grid.412047.4) (ISNI:0000 0004 0532 3650)
2 Kaohsiung Medical University, Research Center for Precision Environmental Medicine, Kaohsiung, Taiwan (GRID:grid.412019.f) (ISNI:0000 0000 9476 5696); I-Shou University, School of Medicine, College of Medicine, Kaohsiung, Taiwan (GRID:grid.411447.3) (ISNI:0000 0004 0637 1806); E-Da Hospital, Department of Obstetrics & Gynecology, Kaohsiung, Taiwan (GRID:grid.414686.9) (ISNI:0000 0004 1797 2180)
3 National Chung Cheng University, Department of Biomedical Sciences, Chia-Yi, Taiwan (GRID:grid.412047.4) (ISNI:0000 0004 0532 3650); National Chung Cheng University, Epigenomics and Human Disease Research Center, Chia-Yi, Taiwan (GRID:grid.412047.4) (ISNI:0000 0004 0532 3650)
4 National Chung Cheng University, Department of Chemical Engineering, Chia-Yi, Taiwan (GRID:grid.412047.4) (ISNI:0000 0004 0532 3650)
5 Kaohsiung Medical University, Research Center for Precision Environmental Medicine, Kaohsiung, Taiwan (GRID:grid.412019.f) (ISNI:0000 0000 9476 5696); National United University, International Master Program of Translational Medicine, Miaoli, Taiwan (GRID:grid.412103.5) (ISNI:0000 0004 0622 7206)
6 Kaohsiung Medical University, Research Center for Precision Environmental Medicine, Kaohsiung, Taiwan (GRID:grid.412019.f) (ISNI:0000 0000 9476 5696)
7 Kaohsiung Medical University, Graduate Institute of Medicine, College of Medicine, Kaohsiung, Taiwan (GRID:grid.412019.f) (ISNI:0000 0000 9476 5696); Kaohsiung Medical University Hospital, Department of Medical Research, Kaohsiung, Taiwan (GRID:grid.412027.2) (ISNI:0000 0004 0620 9374); Kaohsiung Medical University, Research Center for Precision Environmental Medicine, Kaohsiung, Taiwan (GRID:grid.412019.f) (ISNI:0000 0000 9476 5696)
8 Kaohsiung Medical University, Graduate Institute of Medicine, College of Medicine, Kaohsiung, Taiwan (GRID:grid.412019.f) (ISNI:0000 0000 9476 5696); Kaohsiung Medical University Hospital, Department of Medical Research, Kaohsiung, Taiwan (GRID:grid.412027.2) (ISNI:0000 0004 0620 9374); Kaohsiung Municipal Hsiao-Kang Hospital, Department of Pediatrics, Kaohsiung, Taiwan (GRID:grid.415003.3) (ISNI:0000 0004 0638 7138)
9 College of Health Sciences, Kaohsiung Medical University, Department of Public Health, Kaohsiung, Taiwan (GRID:grid.412019.f) (ISNI:0000 0000 9476 5696); Kaohsiung Medical University Hospital, Kaohsiung Medical University, Department of Family Medicine, Kaohsiung, Taiwan (GRID:grid.412027.2) (ISNI:0000 0004 0620 9374); Kaohsiung Medical University, Research Center for Precision Environmental Medicine, Kaohsiung, Taiwan (GRID:grid.412019.f) (ISNI:0000 0000 9476 5696); PhD Program in Environmental and Occupational Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan (GRID:grid.412019.f) (ISNI:0000 0000 9476 5696)
10 National Chung Cheng University, Department of Biomedical Sciences, Chia-Yi, Taiwan (GRID:grid.412047.4) (ISNI:0000 0004 0532 3650); National Chung Cheng University, Epigenomics and Human Disease Research Center, Chia-Yi, Taiwan (GRID:grid.412047.4) (ISNI:0000 0004 0532 3650); National Chung Cheng University, Center for Innovative Research on Aging Society (CIRAS), Chia-Yi, Taiwan (GRID:grid.412047.4) (ISNI:0000 0004 0532 3650); Kaohsiung Medical University, Research Center for Precision Environmental Medicine, Kaohsiung, Taiwan (GRID:grid.412019.f) (ISNI:0000 0000 9476 5696)