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Copyright © 2023 Adil Iqbal Qazi et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/

Abstract

The oxadiazole ring has long been used for the treatment of several diseases. This study aimed to analyze the antihyperglycemic and antioxidant roles of the 1,3,4-oxadiazole derivative with its toxicity. Diabetes was induced through intraperitoneal administration of alloxan monohydrate at 150 mg/kg in rats. Glimepiride and acarbose were used as standards. Rats were divided into groups of normal control, disease control, standard, and diabetic rats (treated with 5, 10, and 15 mg/kg of 1,3,4-oxadiazole derivative). After 14 days of oral administration of 1,3,4-oxadiazole derivatives (5, 10, and 15 mg/kg) to the diabetic group, the blood glucose level, body weight, glycated hemoglobin (HbA1c), insulin level, antioxidant effect, and histopathology of the pancreas were performed. The toxicity was measured by estimating liver enzyme, renal function, lipid profile, antioxidative effect, and liver and kidney histopathological study. The blood glucose and body weight were measured before and after treatment. Alloxan significantly increased blood glucose levels, HbA1c, alanine transaminase, aspartate aminotransferase, urea, cholesterol, triglycerides, and creatinine. In contrast, body weight, insulin level, and antioxidant factors were reduced compared to the normal control group. Treatment with oxadiazole derivatives showed a significant reduction in blood glucose levels, HbA1c, alanine transaminase, aspartate aminotransferase, urea, cholesterol, triglycerides, and creatinine as compared to the disease control group. The 1,3,4-oxadiazole derivative significantly improved body weight, insulin level, and antioxidant factors compared to the disease control group. In conclusion, the oxadiazole derivative showed potential antidiabetic activity and indicated its potential as a therapeutic.

Details

Title
Evaluation of Antidiabetic Activity of Oxadiazole Derivative in Rats
Author
Adil Iqbal Qazi 1 ; Bashir, Ahmad 1 ; Muhammad Umar Khayam Sahibzada 2   VIAFID ORCID Logo  ; Anwar, Fareeha 1 ; Khusro, Ameer 3 ; Alhumaydhi, Fahad A 4   VIAFID ORCID Logo  ; Amany Abdel-Rahman Mohamed 5   VIAFID ORCID Logo  ; Mostafa-Hedeab, Gomaa 6   VIAFID ORCID Logo  ; Talha Bin Emran 7   VIAFID ORCID Logo 

 Riphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore, Punjab, Pakistan 
 Department of Pharmacy, The Sahara College Narowal, Narowal, Punjab, Pakistan 
 Centre for Research and Development, Department of Biotechnology, Hindustan College of Arts & Science, Padur, OMR, Chennai 603103, India 
 Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 52571, Saudi Arabia 
 Department of Forensic Medicine and Toxicology, Zagazig University, Zagazig 44511, Egypt 
 Pharmacology Department & Health Research Unit, Medical College, Jouf University, Saudi Arabia 
 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh; Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh 
Editor
Huantian Cui
Publication year
2023
Publication date
2023
Publisher
John Wiley & Sons, Inc.
ISSN
1741427X
e-ISSN
17414288
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2810632774
Copyright
Copyright © 2023 Adil Iqbal Qazi et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/