Abstract

The COVID-19 pandemic has highlighted the need for FAIR (Findable, Accessible, Interoperable, and Reusable) data more than any other scientific challenge to date. We developed a flexible, multi-level, domain-agnostic FAIRification framework, providing practical guidance to improve the FAIRness for both existing and future clinical and molecular datasets. We validated the framework in collaboration with several major public-private partnership projects, demonstrating and delivering improvements across all aspects of FAIR and across a variety of datasets and their contexts. We therefore managed to establish the reproducibility and far-reaching applicability of our approach to FAIRification tasks.

Details

Title
FAIR in action - a flexible framework to guide FAIRification
Author
Welter, Danielle 1   VIAFID ORCID Logo  ; Juty, Nick 2   VIAFID ORCID Logo  ; Rocca-Serra, Philippe 3   VIAFID ORCID Logo  ; Xu, Fuqi 4   VIAFID ORCID Logo  ; Henderson, David 5   VIAFID ORCID Logo  ; Gu, Wei 1   VIAFID ORCID Logo  ; Strubel, Jolanda 6   VIAFID ORCID Logo  ; Giessmann, Robert T. 7   VIAFID ORCID Logo  ; Emam, Ibrahim 8   VIAFID ORCID Logo  ; Gadiya, Yojana 9   VIAFID ORCID Logo  ; Abbassi-Daloii, Tooba 10   VIAFID ORCID Logo  ; Alharbi, Ebtisam 11   VIAFID ORCID Logo  ; Gray, Alasdair J. G. 12   VIAFID ORCID Logo  ; Courtot, Melanie 13   VIAFID ORCID Logo  ; Gribbon, Philip 9   VIAFID ORCID Logo  ; Ioannidis, Vassilios 14   VIAFID ORCID Logo  ; Reilly, Dorothy S. 15   VIAFID ORCID Logo  ; Lynch, Nick 16   VIAFID ORCID Logo  ; Boiten, Jan-Willem 17   VIAFID ORCID Logo  ; Satagopam, Venkata 1   VIAFID ORCID Logo  ; Goble, Carole 2   VIAFID ORCID Logo  ; Sansone, Susanna-Assunta 3   VIAFID ORCID Logo  ; Burdett, Tony 4   VIAFID ORCID Logo 

1  University of Luxembourg, Luxembourg Centre for Systems Biomedicine, ELIXIR Luxembourg, Belval, Luxembourg (GRID:grid.16008.3f) (ISNI:0000 0001 2295 9843) 
2  The University of Manchester, University of Manchester, Department of Computer Science, Manchester, UK (GRID:grid.5379.8) (ISNI:0000000121662407) 
3  University of Oxford, Oxford e-Research Centre, Department of Engineering Science, Oxford, UK (GRID:grid.4991.5) (ISNI:0000 0004 1936 8948) 
4  European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK (GRID:grid.225360.0) (ISNI:0000 0000 9709 7726) 
5  Bayer AG, Business Development & Licensing & OI, Berlin, Germany (GRID:grid.420044.6) (ISNI:0000 0004 0374 4101) 
6  The Hyve BV, Utrecht, The Netherlands (GRID:grid.511638.8) 
7  Bayer AG, Business Development & Licensing & OI, Berlin, Germany (GRID:grid.420044.6) (ISNI:0000 0004 0374 4101); Institute for Globally Distributed Open Research and Education (IGDORE), Gothenburg, Sweden (GRID:grid.499279.8) 
8  Imperial College, Data Science Institute, London, UK (GRID:grid.7445.2) (ISNI:0000 0001 2113 8111) 
9  Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP) and Fraunhofer Cluster of Excellence for Immune Mediated Diseases (CIMD), Schnackenburgallee 114, Frankfurt, Germany (GRID:grid.510864.e) 
10  Maastricht University, Department of Bioinformatics (BiGCaT), NUTRIM, FHML, Maastricht, The Netherlands (GRID:grid.5012.6) (ISNI:0000 0001 0481 6099) 
11  Umm Al-Qura University, College of Computer and Information Systems, Mecca, Saudi Arabia (GRID:grid.412832.e) (ISNI:0000 0000 9137 6644) 
12  Heriot-Watt University, Department of Computer Science, Edinburgh, UK (GRID:grid.9531.e) (ISNI:0000000106567444) 
13  European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK (GRID:grid.225360.0) (ISNI:0000 0000 9709 7726); 661 University Avenue, Ontario Institute for Cancer Research MaRS Centre, Toronto, Canada (GRID:grid.419890.d) (ISNI:0000 0004 0626 690X) 
14  Vital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland (GRID:grid.419765.8) (ISNI:0000 0001 2223 3006) 
15  Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland (GRID:grid.419481.1) (ISNI:0000 0001 1515 9979) 
16  OpenPhacts Foundation, Cambridge, UK (GRID:grid.419481.1) 
17  Foundation Lygature, Utrecht, Netherlands (GRID:grid.491493.2) 
Pages
291
Publication year
2023
Publication date
2023
Publisher
Nature Publishing Group
e-ISSN
20524463
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41597-023-02167-2
ProQuest document ID
2815861440
Copyright
© The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.