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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Simple Summary

A subgroup of cancers that arises in the zone of the head and neck (HNCs) are caused by some types of human papillomavirus (HPV), so called high-risk (HR)-HPVs. HR-HPVs promote signaling pathways alterations involved in the initiation and progression of cancer. Among them, phosphatidyl inositol 3-kinase (PI3K)/AKT/mTOR signaling is involved in increasing cell proliferation, migration, and invasion. In this review, we dissect the role of PI3K/AKT/mTOR in HR-HPV-associated HNCs development and the impact as a potential therapeutic target.

Abstract

High-risk human papillomaviruses (HR-HPVs) are the causal agents of cervical, anogenital and a subset of head and neck carcinomas (HNCs). Indeed, oropharyngeal cancers are a type of HNC highly associated with HR-HPV infections and constitute a specific clinical entity. The oncogenic mechanism of HR-HPV involves E6/E7 oncoprotein overexpression for promoting cell immortalization and transformation, through the downregulation of p53 and pRB tumor suppressor proteins, among other cellular targets. Additionally, E6/E7 proteins are involved in promoting PI3K/AKT/mTOR signaling pathway alterations. In this review, we address the relationship between HR-HPV and PI3K/AKT/mTOR signaling pathway activation in HNC with an emphasis on its therapeutic importance.

Details

Title
PI3K/AKT/mTOR Signaling Pathway in HPV-Driven Head and Neck Carcinogenesis: Therapeutic Implications
Author
Aguayo, Francisco 1 ; Perez-Dominguez, Francisco 2 ; Osorio, Julio C 2   VIAFID ORCID Logo  ; Oliva, Carolina 2 ; Calaf, Gloria M 3 

 Departamento de Biomedicina, Facultad de Medicina, Universidad de Tarapacá, Arica 1000000, Chile 
 Laboratorio de Oncovirología, Programa de Virología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago 8380000, Chile 
 Instituto de Alta Investigación, Universidad de Tarapacá, Arica 1000000, Chile 
First page
672
Publication year
2023
Publication date
2023
Publisher
MDPI AG
e-ISSN
20797737
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2819329796
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.