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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Due to their distinctive structural features, lyotropic nonlamellar liquid crystalline nanoparticles (LCNPs), such as cubosomes and hexosomes, are considered effective drug delivery systems. Cubosomes have a lipid bilayer that makes a membrane lattice with two water channels that are intertwined. Hexosomes are inverse hexagonal phases made of an infinite number of hexagonal lattices that are tightly connected with water channels. These nanostructures are often stabilized by surfactants. The structure’s membrane has a much larger surface area than that of other lipid nanoparticles, which makes it possible to load therapeutic molecules. In addition, the composition of mesophases can be modified by pore diameters, thus influencing drug release. Much research has been conducted in recent years to improve their preparation and characterization, as well as to control drug release and improve the efficacy of loaded bioactive chemicals. This article reviews current advances in LCNP technology that permit their application, as well as design ideas for revolutionary biomedical applications. Furthermore, we have provided a summary of the application of LCNPs based on the administration routes, including the pharmacokinetic modulation property.

Details

Title
Recent Advances in the Development of Liquid Crystalline Nanoparticles as Drug Delivery Systems
Author
Leu, Jassica S L 1 ; Jasy J X Teoh 1 ; Ling, Angel L Q 1 ; Chong, Joey 1 ; Loo, Yan Shan 2   VIAFID ORCID Logo  ; Intan Diana Mat Azmi 2   VIAFID ORCID Logo  ; Zahid, Noor Idayu 3   VIAFID ORCID Logo  ; Bose, Rajendran J C 4   VIAFID ORCID Logo  ; Thiagarajan Madheswaran 5 

 School of Pharmacy, International Medical University, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Selangor, Malaysia; [email protected] (J.S.L.L.); [email protected] (A.L.Q.L.); [email protected] (J.C.) 
 Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia; [email protected] (Y.S.L.); [email protected] (I.D.M.A.) 
 Centre for Fundamental and Frontier Sciences in Nanostructure Self-Assembly, Department of Chemistry, Faculty of Science, Universiti Malaya, Kuala Lumpur 50603, Selangor, Malaysia; [email protected] 
 Masonic Medical Research Institute, 2150 Bleecker St, Utica, NY 13501, USA; [email protected] 
 Department of Pharmaceutical Technology, School of Pharmacy, International Medical University, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Selangor, Malaysia 
First page
1421
Publication year
2023
Publication date
2023
Publisher
MDPI AG
e-ISSN
19994923
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2819450103
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.