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Copyright © 2023 Kayla M. Parker et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

This cross-sectional investigation examined the relationship between sitting time and insulin resistance in 6931 U.S. adults. The mediating effects of several covariates were evaluated. Self-reported sitting time, measured in minutes per day, was the exposure variable. Insulin resistance (IR), indexed using the natural log of the homeostatic model assessment of insulin resistance (L-HOMA-IR), was the outcome variable. This study used data collected from the 2011–2018 National Health and Nutrition Examination Survey (NHANES). Results showed a strong, positive, dose-response association between sitting time and insulin resistance after adjusting for age, sex, race, and year of assessment (F=12.6, p<0.0001). Across the sitting time tertiles (low, moderate, and high), the L-HOMA-IR means (±SE) each differed from each other (0.37±0.008, 0.40±0.012, and 0.43±0.012). Further controlling for cigarette smoking and physical activity did not alter the significance of the relationship. Adding body mass index (BMI) to the demographic covariates weakened the relationship, but it remained significant. However, the association was no longer significant after adjusting for the demographic covariates and waist circumference (F=1.1, p=0.3349). None of the L-HOMA-IR means (±SE) differed from each other (0.40±0.007, 0.41±0.009, and 0.41±0.008). Overall, waist circumference was a powerful mediating variable between sitting time and insulin resistance. Apparently, time spent sitting is a powerful predictor of IR. However, much of the association between sitting time and IR is a function of differences in waist size. As a strong measure of abdominal adiposity and a significant predictor of multiple metabolic diseases, managing waist size is a health practice to consider when insulin resistance is a concern.

Details

Title
Relationship between Sitting Time and Insulin Resistance in 6931 U.S. Adults: The Mediating Role of Abdominal Adiposity
Author
Parker, Kayla M  VIAFID ORCID Logo  ; Tucker, Larry A  VIAFID ORCID Logo  ; Bailey, Bruce W  VIAFID ORCID Logo  ; Davidson, Lance E  VIAFID ORCID Logo 
Editor
Marco Infante
Publication year
2023
Publication date
2023
Publisher
John Wiley & Sons, Inc.
ISSN
23146745
e-ISSN
23146753
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2822120604
Copyright
Copyright © 2023 Kayla M. Parker et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.