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© 2023. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

There is an increasing evidence supporting the hypothesis that traumatic experiences during early developmental periods might be associated with psychopathology later in life. Maternal deprivation (MD) in rodents has been proposed as an animal model for certain aspects of neuropsychiatric disorders. To determine whether early-life stress leads to changes in GABAergic, inhibitory interneurons in the limbic system structures, specifically the amygdala and nucleus accumbens, 9-day-old Wistar rats were exposed to a 24 hour MD. On postnatal day 60 (P60), the rats were sacrificed for morphometric analysis and their brains were compared to the control group. Results show that MD affect GABAergic interneurons, leading to the decrease in density and size of the calciumbinding proteins parvalbumin-, calbindin-and calretinin-expressing interneurons in the amygdala and nucleus accumbens. This study indicates that early stress in life leads to changes in the number and morphology of the GABAergic, inhibitory interneurons in the amygdala and nucleus accumbens, most probably due to the loss of neurons during postnatal development and it further contributes to understanding the effects of maternal deprivation on brain development.

Details

Title
The long-term effects of maternal deprivation on the number and size of inhibitory interneurons in the rat amygdala and nucleus accumbens
Author
Aleksic, Dubravka; Poleksic, Joko; Agatonovic, Gorana; Djulejic, Vuk; Vulovic, Maja; Aksic, Miljana; Reiss, Gebhard; Hamad, Mohammad I K; Jakovcevski, Igor; Aksic, Milan
Section
ORIGINAL RESEARCH article
Publication year
2023
Publication date
Jun 26, 2023
Publisher
Frontiers Research Foundation
ISSN
16624548
e-ISSN
1662453X
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2829326819
Copyright
© 2023. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.