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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

This study aimed to assess the bone regeneration of critical-size defects in rabbit calvaria filled with freshly crushed extracted teeth, comparing them with BTCP biomaterial and empty sites. Materials and methods: Twenty-one female New Zealand rabbits were used in this study. Two critical-size defects 6 mm in size were created in the skull bone, each with a 3 mm separation between them. Three experimental groups were evaluated: Group A (human sterilized crushed teeth granules alone), Group B (Bioner Bone, Bioner Sitemas Implantológicos), and Group C (unfilled defects). The animals were sacrificed at 4 and 8 weeks. Evaluation of the samples involved histological and histomorphometric analyses with radiographic evaluation. The histological evaluation showed a higher volume reduction in Group A compared with Group B (p < 0.05) and Control. Group A showed the highest values for cortical closure and bone formation around the particles, followed by Group B and Group C (p < 0.05). Within the limitations of this animal study, we can conclude that the use of human tooth particles leads to increased bone formation and reduced connective tissue in critical-size defects in rabbit calvaria when compared to BTCP biomaterial. The calvarial model is a robust base for the evaluation of different biomaterials.

Details

Title
The Use of Human Sterilized Crushed Tooth Particles Compared with BTCP Biomaterial and Empty Defects in Bone Formation inside Critical Rabbit Calvaria Sites
Author
Calvo-Guirado, José Luis 1 ; Cabo-Pastor, Marta Belén 2 ; Martínez-Martínez, Francisco 3   VIAFID ORCID Logo  ; Garcés-Villalá, Miguel Ángel 4   VIAFID ORCID Logo  ; Félix de Carlos-Villafranca 5   VIAFID ORCID Logo  ; García-Carrillo, Nuria 6 ; Fernández-Domínguez, Manuel 7 

 Health Sciences Faculty, Universidad Autónoma de Chile, Santiago de Chile 7500912, Chile 
 Dentistry Department, Universidad CEU Cardenal Herrera, 46001 Valencia, Spain; [email protected] 
 Department of Orthopaedic Surgery and Traumatology, Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain; [email protected] 
 Department of Implant and Biomaterial Research, Fundación Corazón de Jesús, San Juan 5400, Argentina; [email protected] 
 Department of Orthodontics, Faculty of Medicine, University of Oviedo, 33001 Asturias, Spain; [email protected] 
 Department of Veterinary, University of Murcia, 30007 Murcia, Spain; [email protected] 
 Department of Dentistry, Universidad Camilo José Cela, 28001 Madrid, Spain; [email protected] 
First page
638
Publication year
2023
Publication date
2023
Publisher
MDPI AG
e-ISSN
23065354
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2829699457
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.