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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Despite monkeypox (mpox) being a public health emergency, there is limited knowledge about the risk of infectivity from skin viral loads during mpox infection. Thus, the aim of this study was to estimate cutaneous viral loads among mpox patients globally. Several databases, including Cochrane, EBSCOHost, EMBASE, ProQuest, PubMed, Scopus, and Web of Science, and preprint servers were searched concerning skin mpox viral loads in confirmed mpox subjects. In this systematic review and meta-analysis, a total of 331 articles were initially screened after the removal of duplicate entries. A total of nine articles were included in the systematic review and meta-analysis for the overall estimation of viral loads (Ct) using a random-effect model. The pooled cutaneous mpox viral load (lower Ct) was 21.71 (95% CI: 20.68–22.75) with a majority of positivity rates being 100%, highlighting a higher infectivity risk from skin lesions. The current results strongly support that skin mpox viral loads may be a dominant source of rapid transmission during current multi-national outbreaks. This important finding can help in constructing useful measures in relevant health policy.

Details

Title
Viral Loads in Skin Samples of Patients with Monkeypox Virus Infection: A Systematic Review and Meta-Analysis
Author
Rani, Isha 1 ; Satapathy, Prakasini 2   VIAFID ORCID Logo  ; Goyal, Anmol 3 ; Shamim, Muhammad Aaqib 4 ; Pal, Amit 5   VIAFID ORCID Logo  ; Squitti, Rosanna 6   VIAFID ORCID Logo  ; Goswami, Kalyan 5 ; Pradhan, Keerti Bhusan 7   VIAFID ORCID Logo  ; Rustagi, Sarvesh 8   VIAFID ORCID Logo  ; Alaa Hamza Hermis 9 ; Barboza, Joshuan J 10 ; Rodriguez-Morales, Alfonso J 11   VIAFID ORCID Logo  ; Sah, Ranjit 12   VIAFID ORCID Logo  ; Padhi, Bijaya K 13   VIAFID ORCID Logo 

 Department of Biochemistry, Maharishi Markandeshwar College of Medical Sciences and Research (MMCMSR), Sadopur Ambala 134007, India; [email protected]; Global Center for Evidence Synthesis, Chandigarh 160036, India; [email protected] (P.S.); [email protected] (A.G.); 
 Global Center for Evidence Synthesis, Chandigarh 160036, India; [email protected] (P.S.); [email protected] (A.G.); 
 Global Center for Evidence Synthesis, Chandigarh 160036, India; [email protected] (P.S.); [email protected] (A.G.); ; Department of Community Medicine, Maharishi Markandeshwar College of Medical Sciences and Research (MMCMSR), SadopurAmbala 134007, India 
 Global Center for Evidence Synthesis, Chandigarh 160036, India; [email protected] (P.S.); [email protected] (A.G.); ; Department of Pharmacology, All India Institute of Medical Sciences (AIIMS), Jodhpur 342001, India 
 Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Kalyani 741250, India; [email protected] (A.P.); [email protected] (K.G.) 
 Department of Laboratory Science, Research and Development Division, Fatebenefratelli Isola Tiberina, Gemelli Isola, 00186 Rome, Italy 
 Department of Healthcare Management, Chitkara School of Health Sciences, Chitkara University Punjab, Patiala 140401, India; [email protected] 
 School of Applied and Life Sciences, Dehradun 180004, India; [email protected] 
 Nursing Department, Al-Mustaqbal University College, Hillah 51001, Iraq; [email protected] 
10  Escuela de Medicina, Universidad César Vallejo, Trujillo 13007, Peru 
11  Clinical Epidemiology and Biostatistics, School of Medicine, Universidad Científica del Sur, Lima 4861, Peru; [email protected]; Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Beirut P.O. Box 36, Lebanon 
12  Tribhuvan University Teaching Hospital, Kathmandu 44600, Nepal; [email protected]; Department of Clinical Microbiology, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, Pune 411000, India; Department of Public Health Dentistry, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune 411018, India 
13  Department of Community Medicine and School of Public Health, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India 
First page
1386
Publication year
2023
Publication date
2023
Publisher
MDPI AG
e-ISSN
19994915
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2829889030
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.