Full text

Turn on search term navigation

© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Cellular and humoral immunity are both required for SARS-CoV-2 infection recovery and vaccine efficacy. The factors affecting mRNA vaccination-induced immune responses, in healthy and fragile subjects, are still under investigation. Thus, we monitored the vaccine-induced cellular and humoral immunity in healthy subjects and cancer patients after vaccination to define whether a different antibody titer reflected similar rates of cellular immune responses and if cancer has an impact on vaccination efficacy. We found that higher titers of antibodies were associated with a higher probability of positive cellular immunity and that this greater immune response was correlated with an increased number of vaccination side effects. Moreover, active T-cell immunity after vaccination was associated with reduced antibody decay. The vaccine-induced cellular immunity appeared more likely in healthy subjects rather than in cancer patients. Lastly, after boosting, we observed a cellular immune conversion in 20% of subjects, and a strong correlation between pre- and post-boosting IFN-γ levels, while antibody levels did not display a similar association. Finally, our data suggested that integrating humoral and cellular immune responses could allow the identification of SARS-CoV-2 vaccine responders and that T-cell responses seem more stable over time compared to antibodies, especially in cancer patients.

Details

Title
Integration of Cellular and Humoral Immune Responses as an Immunomonitoring Tool for SARS-CoV-2 Vaccination in Healthy and Fragile Subjects
Author
Brisotto, Giulia 1   VIAFID ORCID Logo  ; Montico, Marcella 2   VIAFID ORCID Logo  ; Turetta, Matteo 1   VIAFID ORCID Logo  ; Zanussi, Stefania 1   VIAFID ORCID Logo  ; Cozzi, Maria Rita 1 ; Vettori, Roberto 1 ; Romina Boschian Boschin 1 ; Vinante, Lorenzo 3   VIAFID ORCID Logo  ; Matrone, Fabio 3 ; Revelant, Alberto 3   VIAFID ORCID Logo  ; Palazzari, Elisa 3 ; Innocente, Roberto 3 ; Fanetti, Giuseppe 3   VIAFID ORCID Logo  ; Gerratana, Lorenzo 4   VIAFID ORCID Logo  ; Garutti, Mattia 4   VIAFID ORCID Logo  ; Lisanti, Camilla 4   VIAFID ORCID Logo  ; Bolzonello, Silvia 4 ; Nicoloso, Milena Sabrina 5 ; Steffan, Agostino 1   VIAFID ORCID Logo  ; Muraro, Elena 1   VIAFID ORCID Logo 

 Immunopathology and Cancer Biomarkers Units, Department of Cancer Research and Advanced Diagnostics, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy; [email protected] (M.T.); [email protected] (S.Z.); [email protected] (M.R.C.); [email protected] (R.V.); [email protected] (R.B.B.); [email protected] (A.S.); [email protected] (E.M.) 
 Clinical Trial Office, Scientific Direction, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy; [email protected] 
 Division of Radiation Oncology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy; [email protected] (L.V.); [email protected] (F.M.); [email protected] (A.R.); [email protected] (E.P.); [email protected] (R.I.); [email protected] (G.F.) 
 Department of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy; [email protected] (L.G.); [email protected] (M.G.); [email protected] (C.L.); [email protected] (S.B.) 
 Molecular Oncology Unit, Department of Cancer Research and Advanced Diagnostics, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy; [email protected] 
First page
1276
Publication year
2023
Publication date
2023
Publisher
MDPI AG
e-ISSN
19994915
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2829889055
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.