It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
Prophylactic vaccines for SARS-CoV-2 have lowered the incidence of severe COVID-19, but emergence of viral variants that are antigenically distinct from the vaccine strains are of concern and additional, broadly acting preventive approaches are desirable. Here, we report on a glycolipid termed 7DW8-5 that exploits the host innate immune system to enable rapid control of viral infections in vivo. This glycolipid binds to CD1d on antigen-presenting cells and thereby stimulates NKT cells to release a cascade of cytokines and chemokines. The intranasal administration of 7DW8-5 prior to virus exposure significantly blocked infection by three different authentic variants of SARS-CoV-2, as well as by respiratory syncytial virus and influenza virus, in mice or hamsters. We also found that this protective antiviral effect is both host-directed and mechanism-specific, requiring both the CD1d molecule and interferon-
7DW8-5 is a glycolipid that binds CD1d and stimulates invariant natural killer T (iNKT) cells. Here the authors show that 7DW8-5, when administered intranasally, provides prophylactic anti-viral effects against influenza, RSV, and SARS-CoV-2 in mice or hamsters, and that this effect is mediated by iNKT cells and IFN-γ.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details







1 Columbia University Irving Medical Center, Aaron Diamond AIDS Research Center, New York, USA (GRID:grid.239585.0) (ISNI:0000 0001 2285 2675); Columbia University Irving Medical Center, Division of Infectious Diseases, Department of Medicine, New York, USA (GRID:grid.239585.0) (ISNI:0000 0001 2285 2675)
2 Columbia University Irving Medical Center, Institute of Comparative Medicine, New York, USA (GRID:grid.239585.0) (ISNI:0000 0001 2285 2675)
3 Washington University School of Medicine, Department of Medicine, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002)
4 Columbia University Irving Medical Center, Columbia Center for Human Development, Pulmonary Allergy & Critical Care Medicine, Department of Medicine, New York, USA (GRID:grid.239585.0) (ISNI:0000 0001 2285 2675)
5 Federal University of Minas Gerais, Basic and Applied Virology Laboratory, Department of Microbiology, Belo Horizonte, Brazil (GRID:grid.8430.f) (ISNI:0000 0001 2181 4888)
6 Columbia University Irving Medical Center, Aaron Diamond AIDS Research Center, New York, USA (GRID:grid.239585.0) (ISNI:0000 0001 2285 2675)
7 Washington University School of Medicine, Department of Medicine, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, Department of Molecular Microbiology, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, Department of Pathology and Immunology, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002)
8 Washington University School of Medicine, Department of Medicine, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, Department of Molecular Microbiology, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, Department of Pathology and Immunology, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002); Washington University School of Medicine, The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, St. Louis, USA (GRID:grid.4367.6) (ISNI:0000 0001 2355 7002)
9 Columbia University Irving Medical Center, Aaron Diamond AIDS Research Center, New York, USA (GRID:grid.239585.0) (ISNI:0000 0001 2285 2675); Columbia University Irving Medical Center, Division of Infectious Diseases, Department of Medicine, New York, USA (GRID:grid.239585.0) (ISNI:0000 0001 2285 2675); Columbia University Vagelos College of Physicians and Surgeons, Department of Microbiology and Immunology, New York, USA (GRID:grid.21729.3f) (ISNI:0000000419368729)