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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

The association between serum levels of endothelial lipase (EL) and the serum levels and composition of apolipoprotein B (apoB)-containing lipoproteins in healthy subjects and patients with metabolic syndrome (MS) remained unexplored. Therefore, in the present study, we determined the serum levels and lipid content of apoB-containing lipoproteins using nuclear magnetic resonance (NMR) spectroscopy and examined their association with EL serum levels in healthy volunteers (HVs) and MS patients. EL was significantly negatively correlated with the serum levels of cholesterol in large very low-density lipoprotein (VLDL) particles, as well as with total-cholesterol-, free-cholesterol-, triglyceride-, and phospholipid-contents of VLDL and intermediate-density lipoprotein particles in MS patients but not in HVs. In contrast, EL serum levels were significantly positively correlated with the serum levels of apoB, triglycerides, and phospholipids in large low-density lipoprotein particles in HVs but not in MS patients. EL serum levels as well as the serum levels and lipid content of the majority of apoB-containing lipoprotein subclasses were markedly different in MS patients compared with HVs. We conclude that EL serum levels are associated with the serum levels and lipid content of apoB-containing lipoproteins and that these associations are markedly affected by MS.

Details

Title
Associations between Endothelial Lipase and Apolipoprotein B-Containing Lipoproteins Differ in Healthy Volunteers and Metabolic Syndrome Patients
Author
Klobučar, Iva 1   VIAFID ORCID Logo  ; Klobučar, Lucija 2 ; Lechleitner, Margarete 3 ; Trbušić, Matias 4 ; Pregartner, Gudrun 5 ; Berghold, Andrea 5   VIAFID ORCID Logo  ; Habisch, Hansjörg 3   VIAFID ORCID Logo  ; Madl, Tobias 6   VIAFID ORCID Logo  ; Saša Frank 6 ; Degoricija, Vesna 7 

 Department of Cardiology, Sisters of Charity University Hospital Centre, 10000 Zagreb, Croatia; [email protected] (I.K.); [email protected] (M.T.) 
 Department of Medicine, University Hospital Centre Osijek, 31000 Osijek, Croatia; [email protected] 
 Gottfried Schatz Research Center, Department of Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria; [email protected] (M.L.); [email protected] (H.H.); [email protected] (T.M.) 
 Department of Cardiology, Sisters of Charity University Hospital Centre, 10000 Zagreb, Croatia; [email protected] (I.K.); [email protected] (M.T.); School of Medicine, University of Zagreb, 10000 Zagreb, Croatia; [email protected] 
 Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, 8036 Graz, Austria; [email protected] (G.P.); [email protected] (A.B.) 
 Gottfried Schatz Research Center, Department of Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria; [email protected] (M.L.); [email protected] (H.H.); [email protected] (T.M.); BioTechMed-Graz, 8010 Graz, Austria 
 School of Medicine, University of Zagreb, 10000 Zagreb, Croatia; [email protected]; Department of Medicine, Sisters of Charity University Hospital Centre, 10000 Zagreb, Croatia 
First page
10681
Publication year
2023
Publication date
2023
Publisher
MDPI AG
ISSN
16616596
e-ISSN
14220067
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2836440541
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.