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Abstract
Among numerous approaches to the study of migraine, the nitroglycerin (NTG) model occupies a prominent place, but there is relatively insufficient information about how NTG affects intracranial vessels. In this study we aim to assess the effects of NTG on blood-flow parameters in meningeal vessels measured by imaging photoplethysmography (iPPG) in animal experiments. An amplitude of the pulsatile component (APC) of iPPG waveform was assessed before and within 2.5 h after the NTG administration in saline (n = 13) or sumatriptan (n = 12) pretreatment anesthetized rats in conditions of a closed cranial window. In animals of both groups, NTG caused a steady decrease in blood pressure. In 7 rats of the saline group, NTG resulted in progressive increase in APC, whereas decrease in APC was observed in other 6 rats. In all animals in the sumatriptan group, NTG administration was accompanied exclusively by an increase in APC. Diametrically opposite changes in APC due to NTG indicate a dual effect of this drug on meningeal vasomotor activity. Sumatriptan acts as a synergist of the NTG vasodilating action. The results we obtained contribute to understanding the interaction of vasoactive drugs in the study of the headache pathophysiology and methods of its therapy.
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1 Pavlov First Saint Petersburg State Medical University, Department of Neuropharmacology, Valdman Institute of Pharmacology, Saint Petersburg, Russia (GRID:grid.412460.5); Pavlov Institute of Physiology of the Russian Academy of Sciences, Laboratory of Cortico-Visceral Physiology, Saint Petersburg, Russia (GRID:grid.417772.0) (ISNI:0000 0001 2217 1298)
2 ITMO University, School of Physics and Engineering, Saint Petersburg, Russia (GRID:grid.35915.3b) (ISNI:0000 0001 0413 4629); Institute of Automation and Control Processes of Far East Branch of the Russian Academy of Sciences, Laboratory of Functional Materials and Systems for Photonics, Vladivostok, Russia (GRID:grid.417808.2) (ISNI:0000 0001 1393 1398)
3 Pavlov First Saint Petersburg State Medical University, Department of Neuropharmacology, Valdman Institute of Pharmacology, Saint Petersburg, Russia (GRID:grid.412460.5); Medical Genetic Center, Laboratory of Biochemistry, Saint Petersburg, Russia (GRID:grid.412460.5)
4 Institute of Automation and Control Processes of Far East Branch of the Russian Academy of Sciences, Laboratory of Functional Materials and Systems for Photonics, Vladivostok, Russia (GRID:grid.417808.2) (ISNI:0000 0001 1393 1398); Saint Petersburg State Pediatric Medical University, Faculty of General Therapy, Saint Petersburg, Russia (GRID:grid.445931.e) (ISNI:0000 0004 0471 4078)
5 Institute of Automation and Control Processes of Far East Branch of the Russian Academy of Sciences, Laboratory of Functional Materials and Systems for Photonics, Vladivostok, Russia (GRID:grid.417808.2) (ISNI:0000 0001 1393 1398)