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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background: Mesonephric adenocarcinoma (MA) of the vagina is a rare tumor that arises from mesonephric remnants (Wolffian) in the female genital tract. It is a neoplasm with no significant evidence about its diagnosis, treatment, follow-up and prognosis. Methods: Systematic research of the literature was conducted in Scopus, PubMed/MEDLINE, ScienceDirect and the Cochrane Library, including observational prospective and retrospective studies, case series and case reports. We collected data regarding studies related to diagnosis and treatment options evaluating the following aspects: study design, population, treatment type, rate of surgical complications and fertility outcome. We further included a case report of laparoscopic management of MA with pictorial assays. Results: Thirteen cases of MA of the vagina are available in the literature, including our case report. The median age at diagnosis was 52 years old; the majority of patients reported vaginal bleeding as a symptom (38%); and ultrasound, followed by a magnetic resonance and CT scan were the diagnostic tools most used. In 54% of the cases, a surgical biopsy was performed, and 92% of the patients underwent upfront surgery with an open access or vaginal resection except one case fully managed by minimally invasive surgery. Most of the patients (68%) received adjuvant treatment with chemotherapy or radiotherapy or a combination of them. The mean follow-up period was 6 years. Conclusions: Despite the rarity of this cancer and bizarre location, a minimally invasive approach seems feasible after multidisciplinary evaluation. According to the rarity of this tumor, any future case and follow-up data must be reported in the literature in order to enlarge the knowledge about it.

Details

Title
Diagnosis, Treatment and Prognosis of Mesonephric Adenocarcinoma of the Vagina: A Literature Review and a Case Report
Author
Ferrari, Federico 1 ; Andrea Salvatore Omodei 1   VIAFID ORCID Logo  ; Ferrari, Filippo Alberto 2   VIAFID ORCID Logo  ; Hooman Soleymani Majd 3   VIAFID ORCID Logo  ; Ardighieri, Laura 4 ; Vitale, Salvatore Giovanni 5   VIAFID ORCID Logo  ; Laganà, Antonio Simone 6   VIAFID ORCID Logo  ; Angioni, Stefano 5   VIAFID ORCID Logo  ; Ciravolo, Giuseppe 7 ; Odicino, Franco 1   VIAFID ORCID Logo 

 Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy; [email protected] 
 Department of Obstetrics and Gynecology, AOUI Verona, University of Verona, 37122 Verona, Italy; [email protected] 
 Department of Gynaecological Oncology, Churchill Cancer Centre, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 7LE, UK; [email protected] 
 Department of Pathology, ASST Spedali Civili Brescia, 25123 Brescia, Italy; [email protected] 
 Division of Gynecology and Obstetrics, Department of Surgical Sciences, University of Cagliari, 09124 Cagliari, Italy; [email protected] (S.G.V.); [email protected] (S.A.) 
 Unit of Gynecologic Oncology, ARNAS “Civico—Di Cristina—Benfratelli”, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, Italy; [email protected] 
 Department of Obstetrics and Gynecology, Spedali Civili of Brescia, 25123 Brescia, Italy 
First page
4846
Publication year
2023
Publication date
2023
Publisher
MDPI AG
e-ISSN
20770383
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2843076793
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.