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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Heart transplantation is undergoing a continuous development, with rates of success increasing substantially due to advances in immunosuppressive therapy and surgical techniques. The most worrying complication occurring after cardiac transplantation is graft rejection, a phenomenon that is much affected by matrix metalloproteinases (MMPs), with the role of these proteases in the cardiac remodeling process being well established in the literature. A detailed investigation of the association between MMPs and cardiac rejection is necessary for the future development of more targeted therapies in transplanted patients, and to discover prognostic serum and immunohistochemical markers that will lead to more organized therapeutic management in these patients. The aim of this review is therefore to highlight the main MMPs relevant to cardiovascular pathology, with particular emphasis on those involved in complications related to heart transplantation, including cardiac graft rejection.

Details

Title
Matrix Metalloproteinases and Heart Transplantation—A Pathophysiological and Clinical View
Author
Patrichi, Gabriela 1   VIAFID ORCID Logo  ; Patrichi, Andrei 2 ; Catalin-Bogdan Satala 3 ; Sin, Anca Ileana 1 

 Department of Cell and Molecular Biology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania; [email protected]; Department of Pathology, Clinical County Emergency Hospital, 540136 Targu Mures, Romania; [email protected] (A.P.); [email protected] (C.-B.S.) 
 Department of Pathology, Clinical County Emergency Hospital, 540136 Targu Mures, Romania; [email protected] (A.P.); [email protected] (C.-B.S.) 
 Department of Pathology, Clinical County Emergency Hospital, 540136 Targu Mures, Romania; [email protected] (A.P.); [email protected] (C.-B.S.); Department of Pathology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania 
First page
1295
Publication year
2023
Publication date
2023
Publisher
MDPI AG
ISSN
1010660X
e-ISSN
16489144
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2843085399
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.