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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Many advanced wound healing dressings exist, but there is little high-quality evidence to support them. To determine the performance of a novel amorphous hydrogel (EHO-85) in relation to its application, we compared its rheological properties with those of other standard hydrogels (SH), and we assessed the induction of acceleration of the early stages of wound healing as a secondary objective of a prospective, multicenter, randomized, observer-blinded, controlled trial. The patients were recruited if they had pressure, venous, or diabetic foot ulcers and were treated with EHO-85 (n = 103) or VariHesive® (SH) (n = 92), and their response was assessed by intention-to-treat as wound area reduction (WAR (%)) and healing rate (HR mm2/day) in the second and fourth weeks of treatment. Results: EHO-85 had the highest shear thinning and G′/G″ ratio, the lowest viscous modulus, G″, and relatively low cohesive energy; EHO-85 had a significantly superior effect over SH in WAR and HR, accelerating wound healing in the second and fourth weeks of application (p: 0.002). This superiority is likely based on its optimal moisturizing capacity and excellent pH-lowering and antioxidant properties. In addition, the distinct shear thinning of EHO-85 facilitates spreading by gentle hand pressure, making it easier to apply to wounds. These rheological properties contribute to its improved performance.

Details

Title
EHO-85, Novel Amorphous Antioxidant Hydrogel, Containing Olea europaea Leaf Extract—Rheological Properties, and Superiority over a Standard Hydrogel in Accelerating Early Wound Healing: A Randomized Controlled Trial
Author
Verdú-Soriano, José 1   VIAFID ORCID Logo  ; Marisol de Cristino-Espinar 2 ; Luna-Morales, Silvia 3 ; Dios-Guerra, Caridad 4 ; Casado-Díaz, Antonio 5   VIAFID ORCID Logo  ; Quesada-Gómez, José Manuel 6 ; Dorado, Gabriel 7 ; Berenguer-Pérez, Miriam 1 ; Vílchez, Susana 8 ; Esquena, Jordi 8   VIAFID ORCID Logo  ; Rodríguez-Mañas, Leocadio 9   VIAFID ORCID Logo  ; Lázaro-Martínez, José Luis 10   VIAFID ORCID Logo 

 Department of Community Nursing, Preventive Medicine, Public Health and History of Science, Faculty of Health Sciences, University of Alicante, 03690 Alicante, Spain; [email protected] 
 Pharmacy Department, Reina Sofia University Hospital, 14004 Córdoba, Spain; [email protected]; Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sofía University Hospital, University of Córdoba, 14004 Córdoba, Spain; [email protected] (S.L.-M.); [email protected] (C.D.-G.); [email protected] (J.M.Q.-G.) 
 Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sofía University Hospital, University of Córdoba, 14004 Córdoba, Spain; [email protected] (S.L.-M.); [email protected] (C.D.-G.); [email protected] (J.M.Q.-G.); Occidente Health Center, Córdoba and Guadalquivir Health Management Area, 14005 Córdoba, Spain 
 Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sofía University Hospital, University of Córdoba, 14004 Córdoba, Spain; [email protected] (S.L.-M.); [email protected] (C.D.-G.); [email protected] (J.M.Q.-G.); Occidente Health Center, Córdoba and Guadalquivir Health Management Area, 14005 Córdoba, Spain; Department of Nursing, Faculty of Medicine and Nursing, University of Cordoba, 14004 Córdoba, Spain 
 Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sofía University Hospital, University of Córdoba, 14004 Córdoba, Spain; [email protected] (S.L.-M.); [email protected] (C.D.-G.); [email protected] (J.M.Q.-G.); Endocrinology and Nutrition Unit, Reina Sofia University Hospital, 14004 Cordoba, Spain; Consortium for Biomedical Research in Frailty & Healthy Ageing (CIBERFES), Institute of Health Carlos III, 28029 Madrid, Spain; [email protected] (G.D.); [email protected] (L.R.-M.) 
 Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sofía University Hospital, University of Córdoba, 14004 Córdoba, Spain; [email protected] (S.L.-M.); [email protected] (C.D.-G.); [email protected] (J.M.Q.-G.); Consortium for Biomedical Research in Frailty & Healthy Ageing (CIBERFES), Institute of Health Carlos III, 28029 Madrid, Spain; [email protected] (G.D.); [email protected] (L.R.-M.) 
 Consortium for Biomedical Research in Frailty & Healthy Ageing (CIBERFES), Institute of Health Carlos III, 28029 Madrid, Spain; [email protected] (G.D.); [email protected] (L.R.-M.); Dep. Bioquímica y Biología Molecular, Campus Rabanales C6-1-E17, Campus de Excelencia Internacional Agroalimentario (ceiA3), Universidad de Córdoba, 14071 Córdoba, Spain 
 Institute of Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Científicas (IQAC-CSIC), 08034 Barcelona, Spain; [email protected] (S.V.); [email protected] (J.E.); Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Institute of Health Carlos III, 28029 Madrid, Spain 
 Consortium for Biomedical Research in Frailty & Healthy Ageing (CIBERFES), Institute of Health Carlos III, 28029 Madrid, Spain; [email protected] (G.D.); [email protected] (L.R.-M.); Geriatric Research Group, Biomedical Research Foundation at Getafe University Hospital, 28905 Getafe, Spain; Department of Geriatrics, University Hospital of Getafe, 28905 Getafe, Spain 
10  Diabetic Foot Unit, University Podiatry Clinic, Complutense University of Madrid, 28040 Madrid, Spain; [email protected] 
First page
1925
Publication year
2023
Publication date
2023
Publisher
MDPI AG
e-ISSN
19994923
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2843101131
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.