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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

This research theoretically and experimentally develops a hollow-fiber dialysis module coupled with ultrafiltration operations by introducing a trans-membrane pressure during the membrane dialysis process, which can be applied to the waste metabolic end products in the human body for improving the dialysis efficiency. The solutes were transported by both diffusion and convection from the concentration driving-force gradient between retentate and dialysate phases across the membrane, compared to the traditional dialysis processes by diffusion only. A two-dimensional modeling of such a dialysis-and-ultrafiltration system in the hollow-fiber dialysis module was formulated and solved using the stream function coupled with the perturbation method to obtain the velocity distributions of retentate and dialysate phases, respectively. The purpose of the present work is to investigate the effect of ultrafiltration on the dialysis rate in the hollow-fiber dialyzer with ultrafiltration operations. A highest level of dialysis rate improvement up to about seven times (say 674.65% under Va=20 mL/min) was found in the module with ultrafiltration rate Vw=10 mL/min and membrane sieving coefficient θ=1, compared to that in the system without operating ultrafiltration. Considerable dialysis rate improvements on mass transfer were obtained by implementing a hollow-fiber dialysis-and-ultrafiltration system, instead of using the hollow-fiber dialyzer without ultrafiltration operation. The experimental runs were carried out under the same operating conditions for the hollow-fiber dialyzers of the two experimental runs with and without ultrafiltration operations for comparisons. A very reasonable prediction by the proposed mathematical model was observed.

Details

Title
Two-Dimensional Theoretical Analysis and Experimental Study of Mass Transfer in a Hollow-Fiber Dialysis Module Coupled with Ultrafiltration Operations
Author
Ho, Chii-Dong 1   VIAFID ORCID Logo  ; Jr-Wei Tu 1 ; Chen, Yih-Hang 1   VIAFID ORCID Logo  ; Chew, Thiam Leng 2   VIAFID ORCID Logo 

 Department of Chemical and Materials Engineering, Tamkang University, Tamsui, New Taipei 251301, Taiwan[email protected] (Y.-H.C.) 
 Department of Chemical Engineering, Faculty of Engineering, Universiti Teknologi Petronas, Seri Iskandar 32610, Perak, Malaysia; [email protected]; CO2 Research Center (CO2RES), Institute of Contaminant Management, Universiti Teknologi Petronas, Seri Iskandar 32610, Perak, Malaysia 
First page
702
Publication year
2023
Publication date
2023
Publisher
MDPI AG
e-ISSN
20770375
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2857126266
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.