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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Schistosomiasis is a tropical disease transmitted in an aqueous environment by cercariae from the Schistosoma genus. This disease affects 200 million people living in risk areas around the world. The control of schistosomiasis is realized by chemotherapy, wastewater sanitation, health education, and mollusk control using molluscicidal agents. This work evaluates the effects of a nanoemulsion containing essential oil from Myrciaria floribunda leaves as a molluscicidal and cercaricidal agent against Biomphalaria glabrata mollusks and Schistosoma mansoni cercariae. The Myrciaria floribunda essential oil from leaves showed nerolidol, β-selinene, 1,8 cineol, and zonarene as major constituents. The formulation study suggested the F3 formulation as the most promising nanoemulsion with polysorbate 20 and sorbitan monooleate 80 (4:1) with 5% (w/w) essential oil as it showed a smaller droplet size of approximately 100 nm with a PDI lower than 0.3 and prominent bluish reflection. Furthermore, this nanoemulsion showed stability after 200 days under refrigeration. The Myrciaria floribunda nanoemulsion showed LC50 values of 48.11 µg/mL, 29.66 µg/mL, and 47.02 µg/mL in Biomphalaria glabrata embryos, juveniles, and adult mollusks, respectively, after 48 h and 83.88 µg/mL for Schistosoma mansoni cercariae after 2 h. In addition, a survival of 80% was observed in Danio rerio, and the in silico toxicity assay showed lower overall human toxicity potential to the major compounds in the essential oil compared to the reference molluscicide niclosamide. These results suggest that the nanoemulsion of Myrciaria floribunda leaves may be a promising alternative for schistosomiasis control.

Details

Title
Molluscicidal and Cercaricidal Effects of Myrciaria floribunda Essential Oil Nanoemulsion
Author
Francisco Paiva Machado 1   VIAFID ORCID Logo  ; Folly, Diogo 1   VIAFID ORCID Logo  ; Esteves, Ricardo 1   VIAFID ORCID Logo  ; Ruppelt, Bettina Monika 2 ; Victoria Marques da Silva 2 ; Ana Paula dos Santos Matos 3   VIAFID ORCID Logo  ; José Augusto Albuquerque dos Santos 4 ; Leonardo da Silva Rangel 5   VIAFID ORCID Logo  ; Marcelo Guerra Santos 6   VIAFID ORCID Logo  ; Natalia Lidmar von Ranke 7 ; Carlos Rangel Rodrigues 7 ; Ricci-Junior, Eduardo 3   VIAFID ORCID Logo  ; Rocha, Leandro 2   VIAFID ORCID Logo  ; Robson Xavier Faria 4   VIAFID ORCID Logo 

 Laboratório de Tecnologia de Produtos Naturais (LTPN), Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal Fluminense, Rua, Mario Viana, 523, Santa Rosa, Niterói 24241-000, RJ, Brazil; Programa de Pós-Graduação em Biotecnologia Vegetal e Bioprocessos (PBV), Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-599, RJ, Brazil 
 Laboratório de Tecnologia de Produtos Naturais (LTPN), Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal Fluminense, Rua, Mario Viana, 523, Santa Rosa, Niterói 24241-000, RJ, Brazil 
 Laboratório de Desenvolvimento Galênico (LADEG), Departamento de Fármacos e Medicamentos, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-599, RJ, Brazil 
 Laboratório de Avaliação e Promoção da Saúde Ambiental (LAPSA), Instituto Oswaldo Cruz, Rio de Janeiro 21040-360, RJ, Brazil 
 Laboratório de Avaliação e Promoção da Saúde Ambiental (LAPSA), Instituto Oswaldo Cruz, Rio de Janeiro 21040-360, RJ, Brazil; Programa de Pós-Graduação em Ciências e Biotecnologia (PPBI), Universidade Federal Fluminense, Niterói 24241-000, RJ, Brazil 
 Departamento de Ciências, Faculdade de Formação de Professores, Universidade do Estado do Rio de Janeiro, Dr. Francisco Portela 1470, São Gonçalo 24435-000, RJ, Brazil 
 Laboratório de Modelagem Molecular e QSAR (ModMolQSAR), Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-599, RJ, Brazil 
First page
5944
Publication year
2023
Publication date
2023
Publisher
MDPI AG
e-ISSN
14203049
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2857418430
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.