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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Camillo Golgi was an esteemed Italian physician and biologist who made major advances in malaria research between the late 19th and early 20th centuries. His groundbreaking contributions in histology, especially through the development of the Golgi staining technique, revolutionized our understanding of cell structures—including Plasmodium parasites—through visualization. Golgi staining also allowed researchers to observe its complex life cycle while documenting it. His careful observations of malaria led to the identification and characterization of its various stages, both asexual forms within human red blood cells, as well as sexual forms carried by mosquito vectors. Golgi’s research highlighted the key role mosquitoes play in malaria transmission. He demonstrated the presence of Plasmodium sporozoites within the salivary glands of infected mosquitoes, providing insight into its life cycle and the dynamics of parasite transmission. His comprehensive approach contributed significantly to our understanding of malaria as a systemic illness, leading to subsequent research efforts within this field. The Golgi Protein complex is often located within the cis-Golgi of blood parasite life cycles and mosquito stages, indicating its possible role in optimizing asexual development during blood stages. Furthermore, its expression can be conditionally repressed or its gene can be inactivated to optimize this potential role in improving its functionality for optimizing sexual development during blood stages. Camillo Golgi remains one of the leading lights of malaria research today. His innovative staining techniques, detailed observations, and insightful interpretations have laid the groundwork for subsequent discoveries and advancements in malaria studies. By deciphering intricate parasite life cycle interactions with hosts, his work has provided invaluable insights into malaria biology, pathogenesis, and epidemiology.

Details

Title
Camillo Golgi’s Impact on Malaria Studies
Author
Simoiu, Madalina 1 ; Codreanu, Radu 2 ; Antonio-Daniel Corlatescu 3   VIAFID ORCID Logo  ; Andreeea, Marilena Pauna 4 ; Cilievici, Suzana Elena 5 

 Department of Parasitology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania; [email protected] (M.S.); [email protected] (R.C.); National Institute of Infectious Diseases “Prof. Dr. Matei Balș”, 021105 Bucharest, Romania 
 Department of Parasitology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania; [email protected] (M.S.); [email protected] (R.C.) 
 Department of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania; [email protected] 
 Department of Epidemiology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania; [email protected]; Military Medicine Institute, 010919 Bucharest, Romania 
 Department of Parasitology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania; [email protected] (M.S.); [email protected] (R.C.); Colentina Clinical Hospital, 021151 Bucharest, Romania 
First page
2156
Publication year
2023
Publication date
2023
Publisher
MDPI AG
e-ISSN
20734409
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2862207385
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.