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Abstract
Identifying and planning treatment for retinopathy of prematurity (ROP) using telemedicine is becoming increasingly ubiquitous, necessitating a grading system to help caretakers of at-risk infants gauge disease severity. The modified ROP Activity Scale (mROP-ActS) factors zone, stage, and plus disease into its scoring system, addressing the need for assessing ROP’s totality of binocular burden via indirect ophthalmoscopy. However, there is an unmet need for an alternative score which could facilitate ROP identification and gauge disease improvement or deterioration specifically on photographic telemedicine exams. Here, we propose such a system (Telemedicine ROP Severity Score [TeleROP-SS]), which we have compared against the mROP-ActS. In our statistical analysis of 1568 exams, we saw that TeleROP-SS was able to return a score in all instances based on the gradings available from the retrospective SUNDROP cohort, while mROP-ActS obtained a score of 80.8% in right eyes and 81.1% in left eyes. For treatment-warranted ROP (TW-ROP), TeleROP-SS obtained a score of 100% and 95% in the right and left eyes respectively, while mROP-ActS obtained a score of 70% and 63% respectively. The TeleROP-SS score can identify disease improvement or deterioration on telemedicine exams, distinguish timepoints at which treatments can be given, and it has the adaptability to be modified as needed.
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1 Stanford University School of Medicine, Department of Ophthalmology, Horngren Family Vitreoretinal Center, Byers Eye Institute, Palo Alto, USA (GRID:grid.168010.e) (ISNI:0000000419368956)
2 Carleton College, Northfield, USA (GRID:grid.253692.9) (ISNI:0000 0004 0445 5969)
3 Harvard Medical School, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, USA (GRID:grid.38142.3c) (ISNI:000000041936754X)
4 University of Arkansas for Medical Sciences, Department of Ophthalmology, Jones Eye Institute, Little Rock, USA (GRID:grid.241054.6) (ISNI:0000 0004 4687 1637)
5 University of California San Diego, Viterbi Family Department of Ophthalmology, Shiley Eye Institute, La Jolla, USA (GRID:grid.266100.3) (ISNI:0000 0001 2107 4242)
6 Austin Retina Associates, Austin, USA (GRID:grid.266100.3)
7 Harvard Medical School, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, USA (GRID:grid.38142.3c) (ISNI:000000041936754X); Harvard Medical School, Department of Ophthalmology, Boston Children’s Hospital, Boston, USA (GRID:grid.38142.3c) (ISNI:000000041936754X); University of Miami Leonard M. Miller School of Medicine, Department of Ophthalmology, Bascom Palmer Eye Institute, Miami, USA (GRID:grid.26790.3a) (ISNI:0000 0004 1936 8606)
8 University Medicine Greifswald, Department of Ophthalmology, Greifswald, Germany (GRID:grid.461720.6) (ISNI:0000 0000 9263 3446)
9 Catholic University of the Sacred Heart, A. Gemelli Foundation IRCSS, Department of Geriatrics and Neuroscience, Rome, Italy (GRID:grid.8142.f) (ISNI:0000 0001 0941 3192)