Abstract

Purpose

This systematic review and meta-analysis summarize the evidence for the association between Helicobacter pylori infection and Primary Open-Angle Glaucoma.

Methods

Eligible studies reporting an association between H. pylori infection and Glaucoma were identified through an extensive search of the Excerpta Medica (EMBASE), Web of Science, Scopus, and PubMed databases and an assessment of the reference list of the top articles until October 2022. Analysis was performed with random effects model using Stata 16.

Result

Twenty-four studies were included in the systematic review. This study involved 1602 glaucoma patients and 2800 control individuals. The combined RRs of cohort studies and overall combined ORs of case-control studies showed a significant correlation between H. pylori infection and Glaucoma. Subgroup analysis showed that glaucoma patients had a higher risk of having H. pylori infection if they were residents of Europe countries (Cohort: RR: 1.69; 95% CI: 1.3–2.19) and (Case-Control: RR: 3.71; 95% CI: 2.07–6.64), if they had POAG type (Cohort: RR: 1.76; 95% CI: 1.37–2.27) and (Case-Control: RR: 3.71; 95% CI: 2.934.70), if their diagnostic method of HP was histology (Cohort: RR: 1.95; 95% CI: 1.26–3.01) and (Case-Control: RR: 4.06; 95% CI: 2.28–7.22), and if they were over 60 years old (Cohort: RR: 1.63; 95% CI: 1.33-2.00) and (Case-Control: RR: 2.95; 95% CI: 2.27–3.83).

Discussion

The results of this meta-analysis suggest a statistically significant association between Helicobacter pylori infection and Primary Open-Angle Glaucoma.

Details

Title
Association between helicobacter pylori infection and primary open-angle glaucoma: a systematic review and meta-analysis
Author
Elnaz Ezzati Amini; Moradi, Yousef
Pages
1-13
Section
Research
Publication year
2023
Publication date
2023
Publisher
BioMed Central
e-ISSN
14712415
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2865398352
Copyright
© 2023. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.