A three-dose inactivated SARS-CoV-2 vaccine is sufficient to elicit humoral immune responses in people living with HIV-1

Abstract

To investigate whether HIV CD4+ counts could influence vaccine-induced antibody responses in PLWH, we performed a subgroup analysis. [...]ART treatment allowed a more robust response to the inactivated vaccine, resulting in greater RBD-IgG and nAb responses in PLWH, particularly in those with greater than 200 CD4+ T cells/μL [Supplementary Figure 5, http://links.lww.com/CM9/B674]. To further elucidate whether immune status affected the vaccine-induced antibody response in PLWH, we further analyzed the relationship between the patients' CD4+/CD8+ T cell ratio and the antibody response after vaccination. [...]there was a significantly positive correlation between CD4+/CD8+ T cell ratio and nAb or RBD binding IgG [Figure 1H,I and Supplementary Figure 6, http://links.lww.com/CM9/B674]. There was also no correlation between patient age and antibody response to vaccination [Supplementary Figure 7C,D, http://links.lww.com/CM9/B674]. [...]these data indicate that the efficacy of a three-dose inactivated SARS-CoV-2 vaccine was positively correlated with CD4+ T cell count and that the response to immunization is inferior in PLWH with less than 200 CD4+ T cells/μL. This study demonstrates the overall profile and seroconversion patterns of SARS-COV-2 binding IgG and neutralizing antibodies after immunization with a three-dose inactivated SARS-CoV-2 vaccine in serum samples from 236 PLWH.