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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Klippel–Trenanauy syndrome (KTS) is a rare genetic disease determined by overexpression of the phosphatidylinositol-4-5-bisphosphate 3 kinase catalytic subunit (PIK3CA) gene. The clinical presentation is characterized by venous and capillary malformations and lymphatic malformation. To date, no definitive treatment has been suggested in order to improve the clinical symptoms related to the developments of a skin wound. In this case, we describe a young man with KTS that developed a severe skin wound in the lower right limb unresponsive to the common treatment but responsive to a treatment with oxygen-ozone therapy, pulsed magnetic fields (diamagnetic treatment), and topical fixed association of cocum caprylate, oleic acid, quercetin, and 18-β glycyrrhetinic acid. This is the first case that supports a multistep approach to treat a rare and severe disease, and we hope that other studies can support our data.

Details

Title
A Multiple Synergic Treatment for Non-Healing Ulcer Management in a Patient with Klippel–Trenaunay Syndrome
Author
Vocca, Cristina 1 ; Marcianò, Gianmarco 1 ; Rania, Vincenzo 1   VIAFID ORCID Logo  ; Catarisano, Luca 1 ; Palleria, Caterina 1 ; Ciranni, Salvatore 2 ; Torcia, Giuseppina 2 ; Serra, Raffaele 2   VIAFID ORCID Logo  ; Monea, Francesco 3 ; Spaziano, Giuseppe 4   VIAFID ORCID Logo  ; De Sarro, Giovambattista 5   VIAFID ORCID Logo  ; Citraro, Rita 5   VIAFID ORCID Logo  ; Gallelli, Luca 6   VIAFID ORCID Logo 

 Operative Unit of Pharmacology and Pharmacovigilance, “Renato Dulbecco University Hospital”, Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy; [email protected] (C.V.); [email protected] (V.R.); [email protected] (L.C.); [email protected] (C.P.); [email protected] (G.D.S.); [email protected] (R.C.); [email protected] (L.G.) 
 Vascular Surgery Unit, Department of Medical and Surgical Science, University Magna Graecia, 88100 Catanzaro, Italy; [email protected] (S.C.); [email protected] (G.T.); [email protected] (R.S.) 
 Research Center FAS@UMG, Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy; [email protected] 
 Department of Environmental Biological and Pharmaceutical Sciences and Technologies, University of Campania “Luigi Vanvitelli”, 81100 Caserta, Italy; [email protected] 
 Operative Unit of Pharmacology and Pharmacovigilance, “Renato Dulbecco University Hospital”, Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy; [email protected] (C.V.); [email protected] (V.R.); [email protected] (L.C.); [email protected] (C.P.); [email protected] (G.D.S.); [email protected] (R.C.); [email protected] (L.G.); Research Center FAS@UMG, Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy; [email protected] 
 Operative Unit of Pharmacology and Pharmacovigilance, “Renato Dulbecco University Hospital”, Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy; [email protected] (C.V.); [email protected] (V.R.); [email protected] (L.C.); [email protected] (C.P.); [email protected] (G.D.S.); [email protected] (R.C.); [email protected] (L.G.); Research Center FAS@UMG, Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy; [email protected]; Medifarmagen Srl, Spin Off—University of Catanzaro and Mater Domini Hospital, 88100 Catanzaro, Italy 
First page
33
Publication year
2023
Publication date
2023
Publisher
MDPI AG
e-ISSN
2571841X
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2869564348
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.