Content area
Full text
ABSTRACT
Background: Depot medroxyprogesterone acetate (DMPA) is a progesterone derivative synthesized in the laboratory. This substance has the ability to suppress ovulation, induce endometrial shrinkage, and even affect the hypothalamic-pituitary-gonadal axis in the reproductive system. Objective: The purpose of this study was to investigate the effects of administration of green tea extract on reducing visceral fat, increasing leptin levels, and improving the lipid profile in female rats injected with depot medroxyprogesterone acetate (DMPA). Results: This study was to look into the effects of green tea extract administration on visceral fat reduction, leptin levels, and lipid profile improvement as a result of DMPA administration. Analysis of HDL and LDL levels was performed by spectrophotometry. DMPA induced a significant increase in leptin levels compared with the control group (p 0.05). All doses of green tea extract can reduce this increase, with the highest doses reaching levels comparable to the control group (p > 0.05). DMPA significantly increased LDL levels compared to the control group (p < 0.05), and the highest green tea extract dose restored levels similar to the control group. DMPA triggered a decrease in HDL level that was significantly different from the control group (p < 0.05). The first dose of green tea extract can achieve HDL levels comparable to the control group (p > 0.05). Conclusion: It was concluded that green tea extract can protect the metabolic status through decreased leptin and an improvement of the lipid profile induced by DMPA.
Keywords: contraception, tea, lipid metabolism, catechin, weight.
1.BACKGROUND
Depot medroxyprogesterone acetate (DMPA) is a progesterone derivative synthesized in the laboratory. This substance has the ability to suppress ovulation, induce endometrial shrinkage, and even affect the hypothalamic-pituitary-gonadal axis in the reproductive system. Other consequences include suppression of the reproductive cycle, binding to androgenic receptors and glucocorticoids, insulin resistance, and deterioration of cardiometabolic indices (1-5). Weight gain is the most common reason for DMPA users to stop using contraception (6).
Body fat is classified into two types: adipose visceral tissue and subcutaneous adipose tissue. As a risk factor for cardiovascular disease, adipose visceral tissue has a tight association with metabolic disorders (7, 8). Previous research has shown that DMPA users gained weight and gained body fat [9, 10]. However, the mechanism of weight gain...