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ABSTRACT
Background: Psoriasis is a chronic incurable disease, and patients develop associated diseases such as obesity, diabetes, high blood pressure, dyslipidemia. Objective: The aim of the study is to determine the frequency of comorbidities (obesity, diabetes, dyslipidemia, high blood pressure) in men with psoriasis, and the relationship between the duration of psoriasis and the occurrence of comorbidities. Methods: A prospective study was conducted and included 88 male subjects, mean age 52,70 (SD=± 14,05) years, mean psoriasis duration 15,13 (SD=±12,43) years. Results: The incidence of obesity was 30,68%, high blood pressure 29,55%, dyslipidemia 22,73%, diabetes 13,64%. There was a weak correlation between the duration of psoriasis and the occurrence of obesity (r=0,11), dyslipidemia (r=0,18), diabetes (r=0,01), and high blood pressure (r=-0,02). Conclusion: Comorbidities occur in men with psoriasis, and their occurrence is not related to the duration of the disease.
Keywords: psoriasis, comorbidities, men.
1. BACKGROUND
Psoriasis is a chronic inflammatory disease with multiple comorbidities (1). Studies in patients with psoriasis have shown an increased incidence of comorbidities, such as obesity, metabolic syndrome, high blood pressure, dyslipidemia, diabetes (2-5). Although the exact mechanisms of this association are not known, the occurrence of comorbidity is considered to be responsible for the state of chronic inflammation present in patients with psoriasis and elevated levels of proinflammatory cytokines (6). In addition, genetic factors (7), lifestyle of patients (diet, physical activity, habits), prejudices and stigmatization of patients (8) influence. Studies show that the risk of comorbidities, including cardiovascular diseases, is higher in patients with a longer duration of psoriasis (9, 10).
2. OBJECTIVE
To determine the frequency of comorbidities (obesity, diabetes, dyslipidemia, high blood pressure) in men with psoriasis, and the relationship between the duration of psoriasis and the occurrence of comorbidities.
3. PATIENTS AND METHODS
A prospective study was conducted that included 88 men with psoriasis over the age of 18. The mean age of the subjects was 52,70 (SD=±14,05) years. The average duration of psoriasis was 15,13 (SD=±12,43) years. The prevalence of psoriasis was: psoriasis vulgaris 86,36%, psoriasis guttata 13,64% of respondents. Respondents were introduced to the manner and purpose of the research, and signed a written consent to participate in the research. The study included men with psoriasis diagnosed with psoriasis pathohistologically. The study did not...