Abstract

Sleep duration has been linked to a wide range of negative health outcomes and to reduced life expectancy. We present genome-wide association studies of short ( ≤ 5 h) and long ( ≥ 10 h) sleep duration in adults of European (N = 445,966), African (N = 27,785), East Asian (N = 3141), and admixed-American (N = 16,250) ancestry from UK Biobank and the Million Veteran Programme. In a cross-population meta-analysis, we identify 84 independent loci for short sleep and 1 for long sleep. We estimate SNP-based heritability for both sleep traits in each ancestry based on population derived linkage disequilibrium (LD) scores using cov-LDSC. We identify positive genetic correlation between short and long sleep traits (rg = 0.16 ± 0.04; p = 0.0002), as well as similar patterns of genetic correlation with other psychiatric and cardiometabolic phenotypes. Mendelian randomisation reveals a directional causal relationship between short sleep and depression, and a bidirectional causal relationship between long sleep and depression.

Here, the authors investigate the genetic basis of short ( ≤ 5 h) and long ( ≥ 10 h) sleep duration, identifying 84 independent significant risk loci for short sleep and 1 locus for long sleep, and causal associations between sleep and psychiatric traits.

Details

Title
Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration
Author
Austin-Zimmerman, Isabelle 1   VIAFID ORCID Logo  ; Levey, Daniel F. 2   VIAFID ORCID Logo  ; Giannakopoulou, Olga 3 ; Deak, Joseph D. 2   VIAFID ORCID Logo  ; Galimberti, Marco 2   VIAFID ORCID Logo  ; Adhikari, Keyrun 2   VIAFID ORCID Logo  ; Zhou, Hang 2   VIAFID ORCID Logo  ; Denaxas, Spiros 4 ; Irizar, Haritz 5 ; Kuchenbaecker, Karoline 3   VIAFID ORCID Logo  ; McQuillin, Andrew 6   VIAFID ORCID Logo  ; Concato, John 7 ; Buysse, Daniel J. 8 ; Gaziano, J. Michael 9 ; Gottlieb, Daniel J. 10 ; Polimanti, Renato 2   VIAFID ORCID Logo  ; Stein, Murray B. 11   VIAFID ORCID Logo  ; Bramon, Elvira 12   VIAFID ORCID Logo  ; Gelernter, Joel 2   VIAFID ORCID Logo 

1  University College London, Department of Mental Health Neuroscience, Division of Psychiatry, London, UK (GRID:grid.83440.3b) (ISNI:0000 0001 2190 1201); King’s College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK (GRID:grid.13097.3c) (ISNI:0000 0001 2322 6764) 
2  Yale University School of Medicine, Division of Human Genetics, Department of Psychiatry, New Haven, USA (GRID:grid.47100.32) (ISNI:0000 0004 1936 8710); Veterans Affairs Connecticut Healthcare Center, Department of Psychiatry, West Haven, USA (GRID:grid.47100.32) 
3  University College London, Department of Mental Health Neuroscience, Division of Psychiatry, London, UK (GRID:grid.83440.3b) (ISNI:0000 0001 2190 1201); University College London, UCL Genetics Institute, Division of Biosciences, London, UK (GRID:grid.83440.3b) (ISNI:0000 0001 2190 1201) 
4  University College London, Health Data Research UK, Institute of Health Informatics, London, UK (GRID:grid.83440.3b) (ISNI:0000000121901201) 
5  University College London, Department of Mental Health Neuroscience, Division of Psychiatry, London, UK (GRID:grid.83440.3b) (ISNI:0000 0001 2190 1201); Icahn School of Medicine at Mount Sinai, Department of Genetics & Genomic Sciences and Department of Pediatrics, New York, USA (GRID:grid.59734.3c) (ISNI:0000 0001 0670 2351) 
6  University College London, Department of Mental Health Neuroscience, Division of Psychiatry, London, UK (GRID:grid.83440.3b) (ISNI:0000 0001 2190 1201) 
7  Yale University, School of Medicine, New Haven, USA (GRID:grid.47100.32) (ISNI:0000000419368710); Food and Drug Administration (FDA), Office of Medical Policy, Center for Drug Evaluation and Research, Silver Spring, USA (GRID:grid.483500.a) (ISNI:0000 0001 2154 2448) 
8  University of Pittsburgh, Department of Psychiatry, Pittsburgh, USA (GRID:grid.21925.3d) (ISNI:0000 0004 1936 9000) 
9  VA Boston Healthcare System, Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), Boston, USA (GRID:grid.410370.1) (ISNI:0000 0004 4657 1992); Brigham & Women’s Hospital and Harvard Medical School, Department of Medicine, Boston, USA (GRID:grid.62560.37) (ISNI:0000 0004 0378 8294) 
10  1400 VFW Parkway (111PI), VA Boston Healthcare System, West Roxbury, USA (GRID:grid.410370.1) (ISNI:0000 0004 4657 1992); Brigham & Women’s Hospital, Division of Sleep and Circadian Disorders, Boston, USA (GRID:grid.62560.37) (ISNI:0000 0004 0378 8294); Harvard Medical School, Division of Sleep Medicine, Boston, USA (GRID:grid.38142.3c) (ISNI:000000041936754X) 
11  VA San Diego Healthcare System, Psychiatry Service, San Diego, USA (GRID:grid.410371.0) (ISNI:0000 0004 0419 2708); University of California, San Diego, Departments of Psychiatry and Herbert Wertheim School of Public Health, La Jolla, USA (GRID:grid.266100.3) (ISNI:0000 0001 2107 4242) 
12  University College London, Department of Mental Health Neuroscience, Division of Psychiatry, London, UK (GRID:grid.83440.3b) (ISNI:0000 0001 2190 1201); University College London, Institute of Cognitive Neuroscience, London, UK (GRID:grid.83440.3b) (ISNI:0000000121901201) 
Pages
6059
Publication year
2023
Publication date
2023
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41467-023-41249-y
ProQuest document ID
2869802654
Copyright
© The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.