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Abstract
Pancreatic enzyme replacement therapy (PERT) has been recommended as the preferred method for pancreatic exocrine insufficiency caused by chronic pancreatitis (CP). However, at present, the patient-related factors for the poor PERT management are not clear, and there are no studies on the adherence to PERT in patients with CP in East China. This was a mixed-method study following the principle of sequential explanatory design and included two parts: a quantitative and qualitative study. A cross-sectional survey of medication adherence (MA) was first carried out, followed by a semi-structured interview to further explore and explain the influencing factors of adherence to PERT. Of the 148 patients included in this study, 48.0% had poor MA and only 12.8% had good MA. Multivariate logistic regression showed that lower levels of education and income were contributing factors for non-adherence to PERT. Semi-structured interviews with 24 patients revealed that the reasons for non-adherence also included lack of knowledge, self-adjustment of PERT, lifetime of medication, side effects of PERT, forgetfulness, financial burdens, and accessibility issues. The adherence to PERT was poor among patients with CP in East China. Healthcare providers should personalize medication strategies to improve patients’ MA.
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Details
1 Changhai Hospital, Naval Medical University, Department of Gastroenterology, Shanghai, China (GRID:grid.411525.6) (ISNI:0000 0004 0369 1599); Chinese Academy of Medical Sciences & Peking Union Medical College, School of Nursing, Beijing, China (GRID:grid.506261.6) (ISNI:0000 0001 0706 7839); Yangzhou University, Pancreatic Center, Department of Gastroenterology, Affiliated Hospital of Yangzhou University, Yangzhou, China (GRID:grid.268415.c)
2 Changhai Hospital, Naval Medical University, Department of Gastroenterology, Shanghai, China (GRID:grid.411525.6) (ISNI:0000 0004 0369 1599)
3 Zhejiang University, Faculty of Nursing, School of Medicine, Hangzhou, China (GRID:grid.13402.34) (ISNI:0000 0004 1759 700X)
4 Yangzhou University, Pancreatic Center, Department of Gastroenterology, Affiliated Hospital of Yangzhou University, Yangzhou, China (GRID:grid.268415.c)