Full Text

Turn on search term navigation

© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Simple Summary

In this study, we used Taiwan’s National Health Insurance Research Database to investigate the potential association between sleep disorder (SD) and colorectal cancer (CRC) after matching 177,707 patients with SD and without a history of CRC with 177,707 non-SD and non-CRC Taiwanese citizens without SD and without CRC based on age and gender. The results demonstrated a significantly higher likelihood of developing CRC in SD patients compared to the control group. Subgroup analysis revealed that among the four different types of SD, the insomnia group exhibited a significantly elevated risk of CRC. It should be noted that individuals simultaneously affected with sleep apnea and insomnia had a significantly higher risk of developing CRC than those with either condition alone. These research findings suggest a potentially higher risk of CRC in Taiwanese SD patients, underscoring the need to explore the relationship between SD and CRC risk.

Abstract

The impact of sleep disorders (SDs), particularly sleep apnea (SA), on the development of colorectal cancer (CRC) has been the subject of significant research. However, the potential contribution of other SDs to the incidence of CRC remains unexplored. The objective of this study was to examine the effects of SDs on the risk of developing CRC. This study assessed CRC risk among individuals diagnosed with SDs compared with age- and sex-matched unaffected individuals. A longitudinal, nationwide, population-based cohort study was conducted using data from the Taiwan National Health Insurance Research Database (NHIRD) encompassing 177,707 individuals diagnosed with SDs and 177,707 matched controls. Cox proportional hazard regression analysis was used to determine the relative increased risk of CRC in individuals with SDs and specific subgroups of SDs. The CRC incidences were 1.32-fold higher (95% CI 1.23–1.42) in the overall SD cohort, 1.17-fold higher (95% CI 0.82–1.68) in the SA cohort, 1.42-fold higher (95% CI 1.31–1.55) in the insomnia cohort, 1.27-fold higher (95% CI 1.17–1.38) in the sleep disturbance cohort, and 1.00-fold higher (95% CI 0.77–1.29) in the other SD cohort, after adjusting for age, sex, and comorbidities.

Details

Title
The Effects of Different Types of Sleep Disorder on Colorectal Cancer: A Nationwide Population-Based Cohort Study
Author
Po-Lin, Chiang 1 ; Wen-Rui, Hao 2   VIAFID ORCID Logo  ; Hong-Jye, Hong 3 ; Chun-Chao, Chen 4   VIAFID ORCID Logo  ; Chun-Chih Chiu 5 ; Yu-Ann, Fang 5 ; Tsung-Lin, Yang 6   VIAFID ORCID Logo  ; Yu-Hsin, Lai 7 ; Ming-Yao, Chen 7 ; Hsu, Min-Huei 8   VIAFID ORCID Logo  ; Kuan-Rau Chiou 2 ; Kuan-Jie, Lin 9 ; Tsung-Yeh, Yang 5 ; Hsin Hsiu 10   VIAFID ORCID Logo  ; Ju-Chi, Liu 2 

 Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan[email protected] (T.-Y.Y.); Department of General Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan 
 Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan[email protected] (T.-Y.Y.); Taipei Heart Institute, Taipei Medical University, Taipei 11031, Taiwan[email protected] (K.-J.L.); Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan 
 School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung City 404333, Taiwan 
 Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan[email protected] (T.-Y.Y.); Taipei Heart Institute, Taipei Medical University, Taipei 11031, Taiwan[email protected] (K.-J.L.); Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan 
 Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan[email protected] (T.-Y.Y.); Taipei Heart Institute, Taipei Medical University, Taipei 11031, Taiwan[email protected] (K.-J.L.) 
 Taipei Heart Institute, Taipei Medical University, Taipei 11031, Taiwan[email protected] (K.-J.L.); Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan; Division of Cardiology, Department of Internal Medicine and Cardiovascular Research Center, Taipei Medical University Hospital, Taipei 11031, Taiwan 
 Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan; [email protected] (Y.-H.L.); ; TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei 11031, Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Shuang Ho Hospital, New Taipei City 23561, Taiwan 
 Graduate Institute of Data Science, College of Management, Taipei Medical University, Taipei 11031, Taiwan; Department of Neurosurgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan 
 Taipei Heart Institute, Taipei Medical University, Taipei 11031, Taiwan[email protected] (K.-J.L.); Division of Cardiovascular Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan 
10  Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, No. 43, Section 4, Keelung Road, Taipei 10607, Taiwan 
First page
4728
Publication year
2023
Publication date
2023
Publisher
MDPI AG
e-ISSN
20726694
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2876407075
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.