Abstract

Background

Multiple sclerosis (MS) is widely known to cause brain atrophy due to neurodegeneration. Neuroimaging investigations revealed a direct link between brain atrophy detected by MRI and impairment. Transcranial sonography is a safe, feasible and cost-effective imaging technique. In this study, we aimed to validate B-mode transcranial sonography (TCS) as a marker of neurodegeneration in MS. This study is the first study directed to set cut-off point for brain parenchyma measurement in Egyptian population. An observational, case–control study, conducted on 125 subjects; divided into 2 groups: first group, 71 healthy volunteers and patients’ group (54 patients) with relapsing–remitting multiple sclerosis (RRMS). All studied subjects were assessed using B-mode TCS. Transcranial sonography findings were categorized into: first, assessment of brain atrophy parameters by measuring diameter (cm) of third ventricle and both frontal horns of lateral ventricles. Then, the echogenicity of thalamus and brainstem structures (substantia nigra (SN), red nucleus) planimetric surface area (cm2) were assessed along with their abnormal echogenicity (cm2), while brainstem raphe was assessed semi-quantitatively for its echogenicity (intact or interrupted).

Results

Quantitative measures of brain atrophy: in normal control group the third ventricle diameter mean was 0.2 cm (± 0.08), right and left frontal horn diameter were 0.3 cm (± 0.13) and 0.28 cm (± 0.1), respectively, brain atrophy parameters could differentiate between MS patients and normal control group as a statistically significant (p< 0.001) larger ventricular diameter was found in MS patients. On the other hand, assessment of brain stem structures and thalamus showed no statistical significance between MS patients and normal control except in surface area of both red nuclei.

Conclusions

Brain parenchymal sonography may be used as a tool in assessment of neurodegeneration in MS patients.

Details

Title
Validation of brain parenchyma sonography as a marker of neurodegeneration in multiple sclerosis
Author
Kishk, Nirmeen A. 1 ; Hamdy, Sherif 1 ; Amer, Hanan 1 ; Shalaby, Nevin M. 1 ; Othman, Alshimaa S. 1 ; Mohammad, Mohammad Edrees 1   VIAFID ORCID Logo 

1  Cairo University, Department of Neurology, Faculty of Medicine, Cairo, Egypt (GRID:grid.7776.1) (ISNI:0000 0004 0639 9286) 
Pages
134
Publication year
2023
Publication date
Dec 2023
Publisher
Springer Nature B.V.
ISSN
11101083
e-ISSN
16878329
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s41983-023-00732-5
ProQuest document ID
2877595993
Copyright
© The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.