Abstract

As a common malignant tumor among women, ovarian cancer poses a serious threat to their health. This study demonstrates that long non-coding RNA NRSN2-AS1 is over-expressed in ovarian cancer tissues using patient sample and tissue microarrays. In addition, NRSN2-AS1 is shown to promote ovarian cancer cell proliferation and metastasis both in vitro and in vivo. Mechanistically, NRSN2-AS1 stabilizes protein tyrosine kinase 2 (PTK2) to activate the β-catenin pathway via repressing MG-53-mediated ubiquitinated degradation of PTK2, thereby facilitating ovarian cancer progression. Rescue experiments verify the function of the NRSN2-AS1/PTK2/β-catenin axis and the effects of MG53 on this axis in ovarian cancer cells. In conclusion, this study demonstrates the key role of the NRSN2-AS1/PTK2/β-catenin axis for the first time and explores its potential clinical applications in ovarian cancer.

Details

Title
Long non-coding RNA NRSN2-AS1 promotes ovarian cancer progression through targeting PTK2/β-catenin pathway
Author
Wu, Yi-Bo 1 ; Li, Shen-Yi 2 ; Liu, Jin-Yan 3 ; Xue, Jia-Jia 4 ; Xu, Jin-Fu 5 ; Chen, Ting 6 ; Cao, Tian-Yue 6 ; Zhou, Hui 1 ; Wu, Tian-Tian 5 ; Dong, Chun-Lin 1 ; Qian, Wei-Feng 3 ; Qiao, Long-Wei 7 ; Hou, Shun-Yu 6 ; Wang, Ting 7 ; Shen, Cong 7   VIAFID ORCID Logo 

1  Affiliated Hospital of Jiangnan University, Human Reproductive and Genetic Center, Wuxi, China (GRID:grid.459328.1) (ISNI:0000 0004 1758 9149) 
2  Affiliated Hospital of Jiangnan University, Human Reproductive and Genetic Center, Wuxi, China (GRID:grid.459328.1) (ISNI:0000 0004 1758 9149); Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, Department of Obstetrics, Suzhou, China (GRID:grid.440227.7) (ISNI:0000 0004 1758 3572) 
3  Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, Department of Breast and Thyroid Surgery, Suzhou, China (GRID:grid.440227.7) (ISNI:0000 0004 1758 3572) 
4  Suzhou Dushu Lake Hospital (Dushu Lake Hospital Affiliated to Soochow University), Suzhou, China (GRID:grid.263761.7) (ISNI:0000 0001 0198 0694) 
5  School of Basic Medical Sciences, Nanjing Medical University, State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing, China (GRID:grid.89957.3a) (ISNI:0000 0000 9255 8984) 
6  The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, Department of Gynaecology, Suzhou Municipal Hospital, Suzhou, China (GRID:grid.89957.3a) (ISNI:0000 0000 9255 8984) 
7  Center for Reproduction and Genetics, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, State Key Laboratory of Reproductive Medicine, Suzhou, China (GRID:grid.440227.7) (ISNI:0000 0004 1758 3572) 
Pages
696
Publication year
2023
Publication date
Oct 2023
Publisher
Springer Nature B.V.
e-ISSN
20414889
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41419-023-06214-z
ProQuest document ID
2881060458
Copyright
© The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.