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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Complete blood count-derived ratios have been described as inflammatory biomarkers in several diseases. These hematological scores include the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammatory index ([SIRI]; neutrophils × monocytes/lymphocytes). Our aim was to study how these biomarkers are related to disease expression in a large and well-characterized series of patients with systemic lupus erythematosus (SLE). A total of 284 SLE patients and 181 age- and sex-matched healthy controls were recruited. The NLR, MLR, PLR, and SIRI were calculated, and activity (SLEDAI-2K), severity (Katz), and damage index (SLICC-DI) scores were assessed in patients with SLE. Multivariable linear regression analysis was performed to study whether these scores differ between patients and controls and how they are related to clinical and laboratory features of the disease. Crude cell counts of neutrophils, monocytes, lymphocytes, and platelets were lower in SLE patients compared to controls. Despite this, NLR, MLR, and PRL, but not SIRI, were higher in SLE patients than in controls after multivariable analysis. However, the relationship between the different scores and disease characteristics was limited. Only the Katz severity index revealed a significant positive relationship with SIRI, NLR, and MLR after adjustment for covariates. Similarly, alternative complement cascade activation and low C3 were significantly associated with higher NLR, MLR, and PLR. In conclusion, although cytopenias are a common feature of patients with SLE, hematologic composite scores are independently higher in this population compared to controls. However, the relationship of these scores with the characteristics of the disease is scarce, with the relationship with the complement system being the most consistent.

Details

Title
Blood Composite Scores in Patients with Systemic Lupus Erythematosus
Author
Mercader-Salvans, Júlia 1   VIAFID ORCID Logo  ; García-González, María 2   VIAFID ORCID Logo  ; Quevedo-Abeledo, Juan C 3 ; Quevedo-Rodríguez, Adrián 3   VIAFID ORCID Logo  ; Romo-Cordero, Alejandro 4 ; Ojeda-Bruno, Soledad 3 ; Gómez-Bernal, Fuensanta 5   VIAFID ORCID Logo  ; López-Mejías, Raquel 6   VIAFID ORCID Logo  ; Martín-González, Candelaria 7   VIAFID ORCID Logo  ; González-Gay, Miguel Á 8   VIAFID ORCID Logo  ; Ferraz-Amaro, Iván 9   VIAFID ORCID Logo 

 Division of Dermatology, Hospital Universitario de Canarias, 38320 Tenerife, Spain; [email protected] 
 Division of Rheumatology, Hospital Universitario de Canarias, 38320 Tenerife, Spain; [email protected] 
 Division of Rheumatology, Hospital Doctor Negrín, 35010 Las Palmas de Gran Canaria, Spain; [email protected] (J.C.Q.-A.); [email protected] (A.Q.-R.); [email protected] (S.O.-B.) 
 Division of Internal Medicine, Hospital Universitario de Canarias, 38320 Tenerife, Spain; [email protected] (A.R.-C.); [email protected] (C.M.-G.) 
 Division of Central Laboratory, Hospital Universitario de Canarias, 38320 Tenerife, Spain; [email protected] 
 Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Instituto de Investigación Sanitaria Marqués de Valdecilla (IDIVAL), 39011 Santander, Spain; [email protected] 
 Division of Internal Medicine, Hospital Universitario de Canarias, 38320 Tenerife, Spain; [email protected] (A.R.-C.); [email protected] (C.M.-G.); Department of Internal Medicine, Universidad de La Laguna (ULL), 38200 Tenerife, Spain 
 Division of Rheumatology, IIS-Fundación Jiménez Díaz, 28040 Madrid, Spain; Department of Medicine, University of Cantabria, 39005 Santander, Spain; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2000, South Africa 
 Division of Rheumatology, Hospital Universitario de Canarias, 38320 Tenerife, Spain; [email protected]; Department of Internal Medicine, Universidad de La Laguna (ULL), 38200 Tenerife, Spain 
First page
2782
Publication year
2023
Publication date
2023
Publisher
MDPI AG
e-ISSN
22279059
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2882366462
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.