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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Loco-regional chemotherapy is a strategy used to achieve more precise anticancer drug effect directly on tumor mass, while decreasing whole body exposure, which can lead to undesirable side effects. Thus, the loco-regional chemotherapy is conceptually similar to the targeted drug delivery systems for delivering chemotherapeutics to cancer cells in a certain location of the body. Recently, it has been demonstrated that a novel polymeric film containing the complex between cisplatin (cisPt) and hyaluronan (sodium salt of hyaluronic acid; NaHA) enhanced in vivo efficacy and safety of cisplatin (cisPt) by loco-regional delivery in pleural mesothelioma. Biologically, hyaluronic acid (HA) binds with the CD44 receptor, which is a transmembrane glycoprotein overexpressed by other cancer cells. Thus, administering both cisPt and hyaluronan together as a complex loco-regionally to the tumor site could target cancer cells locally and enhance treatment safety. A slight excess of hyaluronan was required to have more than 85% cisPt complexation. In cell monolayers (2D model) the cisPt/NaHA complex in solution demonstrated dose- and time-dependent cytotoxic effect by decreasing the viability of pancreatic, melanoma, and lung cell lines (they all express CD44). At the same concentration in solution, the complex was as effective as cisPt alone. However, when applied as film to melanoma spheroids (3D model), the complex was superior because it prevented the tumor spheroid growth and, more importantly, the formation of new cell colonies. Hence, cisPt/NaHA complex could work in preventing metastases loco-regionally and potentially avoiding systemic relapses.

Details

Title
In Vitro Assessment of Cisplatin/Hyaluronan Complex for Loco-Regional Chemotherapy
Author
Banella, Sabrina 1   VIAFID ORCID Logo  ; Saraswat, Aishwarya 2 ; Patel, Akanksha 2 ; Serajuddin, Abu T M 2 ; Colombo, Paolo 3 ; Patel, Ketan 2   VIAFID ORCID Logo  ; Colombo, Gaia 4   VIAFID ORCID Logo 

 Department of Life Sciences and Biotechnology, University of Ferrara, 44121 Ferrara, Italy; [email protected] (S.B.); [email protected] (G.C.); College of Pharmacy and Health Sciences, St. John’s University, Queens, NY 11439, USA; [email protected] (A.S.); [email protected] (A.P.); [email protected] (A.T.M.S.) 
 College of Pharmacy and Health Sciences, St. John’s University, Queens, NY 11439, USA; [email protected] (A.S.); [email protected] (A.P.); [email protected] (A.T.M.S.) 
 PlumeStars s.r.l., 43125 Parma, Italy; [email protected] 
 Department of Life Sciences and Biotechnology, University of Ferrara, 44121 Ferrara, Italy; [email protected] (S.B.); [email protected] (G.C.) 
First page
15725
Publication year
2023
Publication date
2023
Publisher
MDPI AG
ISSN
16616596
e-ISSN
14220067
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2888155483
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.