The role of epidemic spreading in seizure dynamics and epilepsy surgery

Abstract

Epilepsy surgery is the treatment of choice for drug-resistant epilepsy patients, but only leads to seizure freedom for roughly two in three patients. To address this problem, we designed a patient-specific epilepsy surgery model combining large-scale magnetoencephalography (MEG) brain networks with an epidemic spreading model. This simple model was enough to reproduce the stereo-tactical electroencephalography (SEEG) seizure propagation patterns of all patients (N = 15), when considering the resection areas (RA) as the epidemic seed. Moreover, the goodness of fit of the model predicted surgical outcome. Once adapted for each patient, the model can generate alternative hypothesis of the seizure onset zone and test different resection strategies in silico. Overall, our findings indicate that spreading models based on patient-specific MEG connectivity can be used to predict surgical outcomes, with better fit results and greater reduction on seizure propagation linked to higher likelihood of seizure freedom after surgery. Finally, we introduced a population model that can be individualized by considering only the patient-specific MEG network, and showed that it not only conserves but improves the group classification. Thus, it may pave the way to generalize this framework to patients without SEEG recordings, reduce the risk of overfitting and improve the stability of the analyses.

Author Summary: In this study we showed that epidemic spreading models that utilise patient-specific data of brain connectivity capture the main aspects of seizure propagation as clinically observed via invasive electroencephalography recordings. Moreover, the goodness of fit of the model was associated with the outcome of epilepsy surgery. We used the model to generate alternative hypothesis of the seizure seed regions, and to simulate the effects of the resective surgery that each patient had undergone, and found indications that larger effects of virtual resections in the model may be associated with seizure freedom after the actual surgery. These findings illustrate how individualized computational models may aid epilepsy surgery planning by identifying alternative seed regions and/or resection strategies, with the ultimate goal of improving surgery outcomes.