Abstract

In this note, we present an innovative approach called “homologous hypothesis tests” that focuses on cross-sectional comparisons of average tumor volumes at different time-points. By leveraging the correlation structure between time-points, our method enables highly efficient per time-point comparisons, providing inferences that are highly efficient as compared to those obtained from a standard two-sample t test. The key advantage of this approach lies in its user-friendliness and accessibility, as it can be easily employed by the broader scientific community through standard statistical software packages.

Details

Title
Leveraging homologous hypotheses for increased efficiency in tumor growth curve testing
Author
Hutson, Alan D. 1 ; Yu, Han 1 ; Attwood, Kristopher 1 

 Roswell Park Comprehensive Cancer Center, Department of Biostatistics and Bioinformatics, Buffalo, USA (GRID:grid.240614.5) (ISNI:0000 0001 2181 8635) 
Pages
19890
Publication year
2023
Publication date
2023
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2889801291
Copyright
© The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.