Abstract

Highlights

MXene/graphene composites possess high potential in future biomedical applications.

The hybridization and surface functionalization of MXene-graphene composites should be further explored to improve the biocompatibility, high stability, and multifunctionality.

The synthesis methods, performances, potential toxicologies, as well as future perspectives of MXene/graphene composites are discussed.

MXenes, transition metal carbides and nitrides with graphene-like structures, have received considerable attention since their first discovery. On the other hand, Graphene has been extensively used in biomedical and medicinal applications. MXene and graphene, both as promising candidates of two-dimensional materials, have shown to possess high potential in future biomedical applications due to their unique physicochemical properties such as superior electrical conductivity, high biocompatibility, large surface area, optical and magnetic features, and extraordinary thermal and mechanical properties. These special structural, functional, and biological characteristics suggest that the hybrid/composite structure of MXene and graphene would be able to meet many unmet needs in different fields; particularly in medicine and biomedical engineering, where high-performance mechanical, electrical, thermal, magnetic, and optical requirements are necessary. However, the hybridization and surface functionalization should be further explored to obtain biocompatible composites/platforms with unique physicochemical properties, high stability, and multifunctionality. In addition, toxicological and long-term biosafety assessments and clinical translation evaluations should be given high priority in research. Although very limited studies have revealed the excellent potentials of MXene/graphene in biomedicine, the next steps should be toward the extensive research and detailed analysis in optimizing the properties and improving their functionality with a clinical and industrial outlook. Herein, different synthesis/fabrication methods and performances of MXene/graphene composites are discussed for potential biomedical applications. The potential toxicological effects of these composites on human cells and tissues are also covered, and future perspectives toward more successful translational applications are presented. The current state-of-the-art biotechnological advances in the use of MXene-Graphene composites, as well as their developmental challenges and future prospects are also deliberated. Due to the superior properties and multifunctionality of MXene-graphene composites, these hybrid structures can open up considerable new horizons in future of healthcare and medicine.

Details

Title
MXene-Graphene Composites: A Perspective on Biomedical Potentials
Author
Mostafavi, Ebrahim 1   VIAFID ORCID Logo  ; Iravani, Siavash 2   VIAFID ORCID Logo 

 Stanford University School of Medicine, Stanford Cardiovascular Institute, Stanford, USA (GRID:grid.168010.e) (ISNI:0000000419368956); Stanford University School of Medicine, Department of Medicine, Stanford, USA (GRID:grid.168010.e) (ISNI:0000000419368956) 
 Isfahan University of Medical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan, Iran (GRID:grid.411036.1) (ISNI:0000 0001 1498 685X) 
Pages
130
Publication year
2022
Publication date
Dec 2022
Publisher
Springer Nature B.V.
ISSN
23116706
e-ISSN
21505551
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2890048713
Copyright
© The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.