Abstract

Cardiovascular diseases pose a major threat worldwide. Common cardiovascular diseases include acute myocardial infarction (AMI), heart failure, atrial fibrillation (AF) and atherosclerosis. Glycolysis process often has changed during these cardiovascular diseases. Lactate, the end-product of glycolysis, has been overlooked in the past but has gradually been identified to play major biological functions in recent years. Similarly, the role of lactate in cardiovascular disease is gradually being recognized. Targeting lactate production, regulating lactate transport, and modulating circulating lactate levels may serve as potential strategies for the treatment of cardiovascular diseases in the future. The purpose of this review is to integrate relevant clinical and basic research on the role of lactate in the pathophysiological process of cardiovascular disease in recent years to clarify the important role of lactate in cardiovascular disease and to guide further studies exploring the role of lactate in cardiovascular and other diseases.

Video Abstract

Details

Title
The role of lactate in cardiovascular diseases
Author
Ouyang, Jun; Wang, Hui; Huang, Jiangnan
Pages
1-14
Section
Review
Publication year
2023
Publication date
2023
Publisher
BioMed Central
e-ISSN
1478811X
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s12964-023-01350-7
ProQuest document ID
2890075188
Copyright
© 2023. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.