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© 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Uromodulin, also named Tamm Horsfall protein, have been associated with renal function and sodium homeostasis regulation. The authors sought to examine the effects of salt intake on plasma and urinary uromodulin levels and the association of its genetic variants with salt sensitivity in Chinese adults. Eighty patients from our natural population cohort were maintained sequentially either on a usual diet for 3 days, a low-salt diet (3.0 g) for 7 days, and a high-salt diet (18.0 g) for an additional 7 days. In addition, the authors studied 514 patients of the Baoji Salt-Sensitive Study, recruited from 124 families who received the same salt intake intervention, and investigated the association of genetic variations in uromodulin gene with salt sensitivity. Plasma uromodulin levels were significantly lower on a high-salt diet than on a baseline diet (28.3 ± 4.5 vs. 54.9 ± 8.8 ng/ml). Daily urinary excretions of uromodulin were significantly decreased on a high-salt diet than on a low-salt diet (28.7 ± 6.7 vs. 157.2 ± 21.7 ng/ml). SNPs rs7193058 and rs4997081 were associated with the diastolic blood pressure (DBP), mean arterial pressure (MAP) responses to the high-salt diet. In addition, several SNPs in the uromodulin gene were significantly associated with pulse pressure (PP) response to the low-salt intervention. This study shows that dietary salt intake affects plasma and urinary uromodulin levels and that uromodulin may play a role in the pathophysiological process of salt sensitivity in the Chinese populations.

Details

Title
Associations of plasma uromodulin and genetic variants with blood pressure responses to dietary salt interventions
Author
Ming-Fei Du 1 ; Shi, Yao 2 ; Zou, Ting 1 ; Jian-Jun Mu 1 ; Xiao-Yu, Zhang 3 ; Gui-Lin, Hu 3 ; Chu, Chao 1 ; Jia, Hao 3 ; Yue-Yuan, Liao 1 ; Chen, Chen 1 ; Wang, Dan 1 ; Ma, Qiong 1 ; Yu, Yan 1 ; Ke-Ke, Wang 1 ; Sun, Yue 1 ; Niu, Ze-Jiaxin 1 ; Rui-Chen, Yan 1 ; Zhang, Xi 3 ; Hao-Wei, Zhou 3 ; Wei-Hua, Gao 4 ; Li, Hao 5 ; Chun-Hua, Li 6 ; Gao, Ke 3 ; Zhang, Jie 7 ; Tie-Lin, Yang 2 ; Wang, Yang 1 

 Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China; Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China 
 Key Laboratory of Biomedical Information Engineering of Ministry of Education, Biomedical Informatics & Genomics Center, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China 
 Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China 
 Department of Cardiology, Xi'an No.1 Hospital, Xi'an, China 
 Department of Critical Care Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China 
 Department of Ophthalmology, Xi’an People’s Hospital, Xi'an, China 
 Department of Cardiology, Xi’an People’s Hospital, Xi'an, China 
Pages
1897-1906
Section
GENETICS
Publication year
2021
Publication date
Oct 2021
Publisher
John Wiley & Sons, Inc.
ISSN
15246175
e-ISSN
17517176
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2890731636
Copyright
© 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.