It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
The differentiation of the two cell types of the root epidermis, atrichoblasts, which give rise to hair cells, and atrichoblasts, which do not develop as hair cells, is determined by a complex regulatory network of transcriptional factors and hormones that act in concert in space and time to define a characteristic pattern of rows of hair cells and non-hair cells interspersed with each other throughout the root epidermis of Arabidopsis thaliana. Previous models have defined a minimal regulatory network that recovers the Wild Type phenotype and some mutants but fails to recover most of the mutant phenotypes, thus limiting its ability to spread. In this work, we propose a diffusion-coupled regulatory genetic network or meta-Gene Regulatory Network model extended to the model previously published by our research group, to describe the patterns of organization of the epidermis of the root epidermis of Arabidopsis thaliana. This network fully or partially recovers loss-of-function mutants of the identity regulators of the epidermal cell types considered within the model. Not only that, this new extended model is able to describe in quantitative terms the distribution of trichoblasts and atrichoblasts defined at each cellular position with respect to the cortex cells so that it is possible to compare the proportions of each cell type at those positions with that reported in each of the mutants analyzed. In addition, the proposed model allows us to explore the importance of the diffusion processes that are part of the lateral inhibition mechanism underlying the network dynamics and their relative importance in determining the pattern in the Wild Type phenotype and the different mutants.
Competing Interest Statement
The authors have declared no competing interest.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer