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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background: Imbalance in the intestinal microbiota can lead to chronic low-grade inflammation. Diet may influence this association. In this study, we aimed to evaluate the interaction between Akkermansia muciniphila (A. muciniphila) and dietary patterns using a proinflammatory index. Methods: We conducted a cross-sectional study with school-aged children. We quantified the relative abundance (RA) of A. muciniphila in feces using a polymerase chain reaction. We collected dietary information through employing a food frequency questionnaire and generated dietary patterns using principal component analysis. We generated a proinflammatory index from serum levels of interleukin-6, interleukin-10, tumor necrosis factor alpha, and adiponectin validated by receptor operating characteristic curves. We evaluated the association between A. muciniphila and the proinflammatory index using logistic regression, including an interaction term with dietary patterns. Results: We found that children with a low RA of A. muciniphila and a high intake of simple carbohydrates and saturated fats had increased odds of being high on the proinflammatory index. However, when the consumption of this dietary pattern is low, children with a low RA of A. muciniphila had decreased odds of being high on the proinflammatory index. Conclusions: Our results suggest that the simultaneous presence of A. muciniphila and diet have a more significant impact on the presence of being high on the proinflammatory index compared to both factors separately.

Details

Title
Interaction between Akkermansia muciniphila and Diet Is Associated with Proinflammatory Index in School-Aged Children
Author
Ayala-García, Juan Carlos 1   VIAFID ORCID Logo  ; García-Vera, Alba Mariel 2 ; Lagunas-Martínez, Alfredo 1   VIAFID ORCID Logo  ; Orbe-Orihuela, Yaneth Citlalli 1 ; Castañeda-Márquez, Ana Cristina 3   VIAFID ORCID Logo  ; Díaz-Benítez, Cinthya Estefhany 1   VIAFID ORCID Logo  ; Bermúdez-Morales, Víctor Hugo 1 ; Cruz, Miguel 4 ; Bahena-Román, Margarita 1 ; Burguete-García, Ana Isabel 1   VIAFID ORCID Logo 

 Centro de Investigación Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca 62100, Mexico; [email protected] (J.C.A.-G.); [email protected] (A.L.-M.); [email protected] (Y.C.O.-O.); [email protected] (C.E.D.-B.); [email protected] (V.H.B.-M.); [email protected] (M.B.-R.) 
 Escuela de Salud Pública de México, Instituto Nacional de Salud Pública, Cuernavaca 62100, Mexico; [email protected] 
 Instituto de Investigación Científica, Universidad Juárez del Estado de Durango, Durango 34100, Mexico; [email protected] 
 Unidad de Investigación Médica en Bioquímica, Centro Médico Nacional Siglo XXI, Ciudad de México 06720, Mexico; [email protected] 
First page
1799
Publication year
2023
Publication date
2023
Publisher
MDPI AG
e-ISSN
22279067
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2892984371
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.