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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Environmental factors such as diet and lifestyle have been shown to influence the development of some intestinal mucosal lesions that may be precursors of colorectal cancer (CRC). The presence of these alterations seems to be associated with misbalanced immunological parameter levels. However, it is still unclear as to which immunological parameters are altered in each phase of CRC development. In this work, we aimed to study the potential relationships of immunological and metabolic parameters with diet in a CRC-related lesion context. Dietary information was obtained using an annual semi-quantitative food-frequency questionnaire (FFQ) from 93 volunteers classified via colonoscopy examination according to the presence of intestinal polyps or adenocarcinoma. Cytokines, chemokines, and adipokines were determined from serum samples. We observed a reduction in adiponectin according to the damage to the mucosa, accompanied by an increase and decrease in C-X-C motif chemokine ligand 10 (CXCL10) and resistin, respectively, in CRC cases. The presence of aberrant crypt foci (ACF) in the polyp group was associated with higher tumor necrosis factor-alpha (TNF-α) concentrations. Vegetables were directly correlated with adiponectin and resistin levels, while the opposite occurred with red meat. A bioactive compound, soluble pectin, showed a negative association with TNF-α. Future dietary strategies could be developed to modulate specific immunological parameters in the context of CRC.

Details

Title
Immunometabolic Profile Associated with Progressive Damage of the Intestinal Mucosa in Adults Screened for Colorectal Cancer: Association with Diet
Author
González, Celestino 1 ; Ruiz-Saavedra, Sergio 2   VIAFID ORCID Logo  ; Gómez-Martín, María 3   VIAFID ORCID Logo  ; Zapico, Aida 3   VIAFID ORCID Logo  ; López-Suarez, Patricia 1   VIAFID ORCID Logo  ; Suárez, Ana 1   VIAFID ORCID Logo  ; Adolfo Suárez González 4   VIAFID ORCID Logo  ; Carmen González del Rey 5 ; Díaz, Elena 1 ; Alonso, Ana 1 ; Clara G de los Reyes-Gavilán 2   VIAFID ORCID Logo  ; González, Sonia 3   VIAFID ORCID Logo 

 Department of Functional Biology, University of Oviedo, 33006 Oviedo, Spain; [email protected] (C.G.); [email protected] (A.Z.); [email protected] (P.L.-S.); [email protected] (A.S.); [email protected] (E.D.); [email protected] (A.A.) 
 Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias (IPLA-CSIC), 33300 Villaviciosa, Spain; [email protected]; Diet, Microbiota and Health Group, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain 
 Department of Functional Biology, University of Oviedo, 33006 Oviedo, Spain; [email protected] (C.G.); [email protected] (A.Z.); [email protected] (P.L.-S.); [email protected] (A.S.); [email protected] (E.D.); [email protected] (A.A.); Diet, Microbiota and Health Group, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain 
 Diet, Microbiota and Health Group, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain; Digestive Service, Central University Hospital of Asturias (HUCA), 33011 Oviedo, Spain 
 Anatomical Pathology Service, Central University Hospital of Asturias (HUCA), 33011 Oviedo, Spain; [email protected] 
First page
16451
Publication year
2023
Publication date
2023
Publisher
MDPI AG
ISSN
16616596
e-ISSN
14220067
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2893072409
Copyright
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.