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© 2023. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

FISH analysis showed copy number gain of the BCR (22q11.2) locus; However, no evidence of BCR/ABL1 gene rearrangement or other cytogenetic lesions was detected. The patient was enrolled in a Phase III randomized trial of Blinatumomab for newly diagnosed BCR-ABL negative B-ALL in adults (ECOG-ACRIN clinical trial E1910). Following cycle two, he was negative for minimal residual disease by flow cytometry analysis, with the following blood count values: white blood cell count of 5 × 109/L (normal range, NR, 4.2–9.1), hemoglobin and mean corpuscular volume of 10.8 g/dL (NR, 13.7–17.5) and 111.3 fL (NR, 79–92), respectively, with platelets of 71 × 109/L (NR, 150–330). After completion of chemotherapy 2 years later, the patient was still in complete remission with negative minimal residual disease by flow cytometry analysis and the following complete blood count values: white blood cell count averaged of 1.9 × 109/L, hemoglobin and mean corpuscular volume of 7.3 g/dL and 103 fL, respectively, and platelets of 17 × 109/L.

Details

Title
Acute myelofibrosis superseding B-lymphoblastic leukemia/lymphoma
Author
Siba El Hussein 1   VIAFID ORCID Logo  ; O'Dywer, Kristen M 2 ; Bennett, John M 3   VIAFID ORCID Logo 

 Department of Pathology, The University of Rochester Medical Center, Rochester, New York 
 Department of Medicine, The University of Rochester Medical Center, Rochester, New York; The Wilmot Cancer Institute, The University of Rochester Medical Center, Rochester, New York 
 Department of Pathology, The University of Rochester Medical Center, Rochester, New York; Department of Medicine, The University of Rochester Medical Center, Rochester, New York; The Wilmot Cancer Institute, The University of Rochester Medical Center, Rochester, New York 
Pages
1179-1181
Section
HAEMATOLOGY IMAGES
Publication year
2023
Publication date
Nov 2023
Publisher
John Wiley & Sons, Inc.
e-ISSN
26886146
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2893998653
Copyright
© 2023. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.