Abstract

The coronavirus disease 2019 (COVID-19) pandemic has been looming globally for three years, yet the diagnostic and treatment methods for COVID-19 are still undergoing extensive exploration, which holds paramount importance in mitigating future epidemics. Host non-coding RNAs (ncRNAs) display aberrations in the context of COVID-19. Specifically, microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) exhibit a close association with viral infection and disease progression. In this comprehensive review, an overview was presented of the expression profiles of host ncRNAs following SARS-CoV-2 invasion and of the potential functions in COVID-19 development, encompassing viral invasion, replication, immune response, and multiorgan deficits which include respiratory system, cardiac system, central nervous system, peripheral nervous system as well as long COVID. Furthermore, we provide an overview of several promising host ncRNA biomarkers for diverse clinical scenarios related to COVID-19, such as stratification biomarkers, prognostic biomarkers, and predictive biomarkers for treatment response. In addition, we also discuss the therapeutic potential of ncRNAs for COVID-19, presenting ncRNA-based strategies to facilitate the development of novel treatments. Through an in-depth analysis of the interplay between ncRNA and COVID-19 combined with our bioinformatic analysis, we hope to offer valuable insights into the stratification, prognosis, and treatment of COVID-19.

Details

Title
Non-coding RNAs expression in SARS-CoV-2 infection: Pathogenesis, clinical significance and therapeutic targets
Author
Liu, Xiaoxing 1 ; Xiong, Wandi 2 ; Ye, Maosen 3 ; Lu, Tangsheng 4 ; Yuan, Kai 1 ; Chang, Suhua 1 ; Han, Ying 4   VIAFID ORCID Logo  ; Wang, Yongxiang 5 ; Lu, Lin 6 ; Bao, Yanping 7 

1  Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China (GRID:grid.11135.37) (ISNI:0000 0001 2256 9319) 
2  Peking University, Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Beijing, China (GRID:grid.11135.37) (ISNI:0000 0001 2256 9319); Hainan University, Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Haikou, China (GRID:grid.428986.9) (ISNI:0000 0001 0373 6302) 
3  Kunming Institute of Zoology, Chinese Academy of Sciences, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, China (GRID:grid.419010.d) (ISNI:0000 0004 1792 7072) 
4  Peking University, National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Beijing, China (GRID:grid.11135.37) (ISNI:0000 0001 2256 9319) 
5  Shandong First Medical University & Shandong Academy of Medical Sciences, Institute of Brain Science and Brain-inspired Research, Jinan, China (GRID:grid.410587.f); Shandong Provincial Hospital Affiliated to Shandong First Medical University, Department of Neurology, Jinan, China (GRID:grid.410638.8) (ISNI:0000 0000 8910 6733) 
6  Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China (GRID:grid.11135.37) (ISNI:0000 0001 2256 9319); Peking University, Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Beijing, China (GRID:grid.11135.37) (ISNI:0000 0001 2256 9319); Peking University, National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Beijing, China (GRID:grid.11135.37) (ISNI:0000 0001 2256 9319) 
7  Peking University, National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Beijing, China (GRID:grid.11135.37) (ISNI:0000 0001 2256 9319); Shandong First Medical University & Shandong Academy of Medical Sciences, Institute of Brain Science and Brain-inspired Research, Jinan, China (GRID:grid.410587.f); Peking University, School of Public Health, Beijing, China (GRID:grid.11135.37) (ISNI:0000 0001 2256 9319) 
Pages
441
Publication year
2023
Publication date
2023
Publisher
Nature Publishing Group
ISSN
20959907
e-ISSN
20593635
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41392-023-01669-0
ProQuest document ID
2898770414
Copyright
© The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.