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Abstract
The present study aimed to compare retinal sensitivity (RS) at each stage and to evaluate the relationship between RS and fundus autofluorescence (FAF) pattern in adult-onset foveomacular vitelliform dystrophy (AOFVD). We retrospectively reviewed 17 eyes of 13 patients with AOFVD. In addition to best-corrected visual acuity (VA), RS within the affected lesion and optical coherence tomography (OCT) measurements were carried out in each participant. All the examined eyes were classified into 4 stages and 3 FAF patterns. RS was superimposed on OCT fundus image and RS within the affected lesion was calculated in each eye. The relationships between visual functions (VA and RS within the affected lesion) and stages and also FAF patterns were analyzed using the linear mixed model. As a result, RS within the affected lesion was significantly associated with FAF pattern, but not with stage. In contrast, VA was correlated with neither stages nor FAF patterns. Our current result suggested that RS within the affected lesion was related to FAF patterns but this was not the case with VA in eyes with AOFVD, demonstrating the usefulness of measuring RS, not only VA, to comprehend the disease status in AOFVD.
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Details
1 The University of Tokyo, Department of Ophthalmology, Tokyo, Japan (GRID:grid.26999.3d) (ISNI:0000 0001 2151 536X)
2 Yokohama City University, Department of Ophthalmology and Micro-Technology, Yokohama, Japan (GRID:grid.268441.d) (ISNI:0000 0001 1033 6139)
3 Seirei Hamamatsu General Hospital, Department of Ophthalmology, Hamamatsu, Japan (GRID:grid.415466.4) (ISNI:0000 0004 0377 8408); Seirei Christopher University, Hamamatsu, Japan (GRID:grid.443623.4) (ISNI:0000 0004 0373 7825)