Abstract

The Latin American Brain Health Institute (BrainLat) has released a unique multimodal neuroimaging dataset of 780 participants from Latin American. The dataset includes 530 patients with neurodegenerative diseases such as Alzheimer’s disease (AD), behavioral variant frontotemporal dementia (bvFTD), multiple sclerosis (MS), Parkinson’s disease (PD), and 250 healthy controls (HCs). This dataset (62.7 ± 9.5 years, age range 21–89 years) was collected through a multicentric effort across five Latin American countries to address the need for affordable, scalable, and available biomarkers in regions with larger inequities. The BrainLat is the first regional collection of clinical and cognitive assessments, anatomical magnetic resonance imaging (MRI), resting-state functional MRI (fMRI), diffusion-weighted MRI (DWI), and high density resting-state electroencephalography (EEG) in dementia patients. In addition, it includes demographic information about harmonized recruitment and assessment protocols. The dataset is publicly available to encourage further research and development of tools and health applications for neurodegeneration based on multimodal neuroimaging, promoting the assessment of regional variability and inclusion of underrepresented participants in research.

Details

Title
The BrainLat project, a multimodal neuroimaging dataset of neurodegeneration from underrepresented backgrounds
Author
Prado, Pavel 1 ; Medel, Vicente 2 ; Gonzalez-Gomez, Raul 2   VIAFID ORCID Logo  ; Sainz-Ballesteros, Agustín 2 ; Vidal, Victor 2 ; Santamaría-García, Hernando 3 ; Moguilner, Sebastian 4 ; Mejia, Jhony 5   VIAFID ORCID Logo  ; Slachevsky, Andrea 6 ; Behrens, Maria Isabel 7 ; Aguillon, David 8   VIAFID ORCID Logo  ; Lopera, Francisco 8 ; Parra, Mario A. 9 ; Matallana, Diana 10 ; Maito, Marcelo Adrián 11 ; Garcia, Adolfo M. 12 ; Custodio, Nilton 13 ; Funes, Alberto Ávila 14 ; Piña-Escudero, Stefanie 15 ; Birba, Agustina 16 ; Fittipaldi, Sol 17   VIAFID ORCID Logo  ; Legaz, Agustina 11 ; Ibañez, Agustín 18   VIAFID ORCID Logo 

1  Universidad Adolfo Ibáñez, Latin American Brain Health Institute (BrainLat), Santiago, Chile (GRID:grid.440617.0) (ISNI:0000 0001 2162 5606); Universidad San Sebastián, Escuela de Fonoaudiología, Facultad de Odontología y Ciencias de la Rehabilitación, Santiago, Chile (GRID:grid.442215.4) (ISNI:0000 0001 2227 4297) 
2  Universidad Adolfo Ibáñez, Latin American Brain Health Institute (BrainLat), Santiago, Chile (GRID:grid.440617.0) (ISNI:0000 0001 2162 5606) 
3  Pontificia Universidad Javeriana, PhD Neuroscience Program, Physiology and Psychiatry Departments, Bogotá, Colombia (GRID:grid.41312.35) (ISNI:0000 0001 1033 6040); Hospital Universitario San Ignacio, Memory and Cognition Center Intellectus, Bogotá, Colombia (GRID:grid.448769.0) (ISNI:0000 0004 0370 0846); University of California San Francisco, Global Brain Health Institute, San Francisco, USA (GRID:grid.266102.1) (ISNI:0000 0001 2297 6811); Trinity College Dublin, Global Brain Health Institute, Dublin, Ireland (GRID:grid.8217.c) (ISNI:0000 0004 1936 9705) 
4  Universidad Adolfo Ibáñez, Latin American Brain Health Institute (BrainLat), Santiago, Chile (GRID:grid.440617.0) (ISNI:0000 0001 2162 5606); Universidad de San Andrés & CONICET, Cognitive Neuroscience Center (CNC), Buenos Aires, Argentina (GRID:grid.441741.3) (ISNI:0000 0001 2325 2241); Massachusetts General Hospital and Harvard Medical School, Department of Neurology, Boston, USA (GRID:grid.32224.35) (ISNI:0000 0004 0386 9924) 
5  Universidad Adolfo Ibáñez, Latin American Brain Health Institute (BrainLat), Santiago, Chile (GRID:grid.440617.0) (ISNI:0000 0001 2162 5606); Universidad de Los Andes, Departamento de Ingeniería Biomédica, Bogotá, Colombia (GRID:grid.7247.6) (ISNI:0000 0004 1937 0714); University of California San Francisco, Memory and Aging Clinic, San Francisco, USA (GRID:grid.266102.1) (ISNI:0000 0001 2297 6811) 
6  University of Chile, Neuropsychology and Clinical Neuroscience Laboratory (LANNEC), Physiopathology Department - Institute of Biomedical Sciences (ICBM), Neurocience and East Neuroscience Departments, Faculty of Medicine, Santiago de Chile, Chile (GRID:grid.443909.3) (ISNI:0000 0004 0385 4466); Geroscience Center for Brain Health and Metabolism, (GERO), Santiago de Chile, Chile (GRID:grid.424112.0) (ISNI:0000 0001 0943 9683); University of Chile, Memory and Neuropsychiatric Center (CMYN), Memory Unit – Neurology Department, Hospital del Salvador and Faculty of Medicine, Santiago de Chile, Chile (GRID:grid.443909.3) (ISNI:0000 0004 0385 4466); Clínica Alemana-Universidad del Desarrollo, Servicio de Neurología, Departamento de Medicina, Santiago de Chile, Chile (GRID:grid.412187.9) (ISNI:0000 0000 9631 4901) 
7  Universidad de Chile, Independencia, Centro de Investigación Clínica Avanzada (CICA), Facultad de Medicina-Hospital Clínico, Santiago, Chile (GRID:grid.443909.3) (ISNI:0000 0004 0385 4466); Hospital Clínico Universidad de Chile, Independencia, Departamento de Neurología y Neurocirugía, Santiago, Chile (GRID:grid.412248.9); Universidad de Chile, Independencia, Departamento de Neurociencia, Facultad de Medicina, Santiago, Chile (GRID:grid.443909.3) (ISNI:0000 0004 0385 4466); Clínica Alemana-Universidad del Desarrollo, Departamento de Neurología y Psiquiatría, Santiago, Chile (GRID:grid.412187.9) (ISNI:0000 0000 9631 4901) 
8  Grupo de Neurociencias de Antioquia de la Universidad de Antioquia, Medellín, Colombia (GRID:grid.412881.6) (ISNI:0000 0000 8882 5269) 
9  University of Strathclyde, School of Psychological Sciences and Health, Glasgow, United Kingdom (GRID:grid.11984.35) (ISNI:0000 0001 2113 8138) 
10  Pontificia Universidad Javeriana, PhD Neuroscience Program, Physiology and Psychiatry Departments, Bogotá, Colombia (GRID:grid.41312.35) (ISNI:0000 0001 1033 6040); Hospital Universitario San Ignacio, Memory and Cognition Center Intellectus, Bogotá, Colombia (GRID:grid.448769.0) (ISNI:0000 0004 0370 0846); Hospital Universitario Fundación Santa Fe de Bogotá, Memory Clinic, Mental Health Department, Bogotá, Colombia (GRID:grid.418089.c) (ISNI:0000 0004 0620 2607) 
11  Universidad Adolfo Ibáñez, Latin American Brain Health Institute (BrainLat), Santiago, Chile (GRID:grid.440617.0) (ISNI:0000 0001 2162 5606); Universidad de San Andrés & CONICET, Cognitive Neuroscience Center (CNC), Buenos Aires, Argentina (GRID:grid.441741.3) (ISNI:0000 0001 2325 2241) 
12  University of California San Francisco, Global Brain Health Institute, San Francisco, USA (GRID:grid.266102.1) (ISNI:0000 0001 2297 6811); Universidad de San Andrés & CONICET, Cognitive Neuroscience Center (CNC), Buenos Aires, Argentina (GRID:grid.441741.3) (ISNI:0000 0001 2325 2241); Universidad de Santiago de Chile, Departamento de Lingüística y Literatura, Facultad de Humanidades, Santiago, Chile (GRID:grid.412179.8) (ISNI:0000 0001 2191 5013) 
13  Peruvian Institute of Neurosciences, Unit Cognitive Impairment and Dementia Prevention, Lima, Peru (GRID:grid.412179.8) 
14  Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Geriatrics Department, Mexico City, Mexico (GRID:grid.416850.e) (ISNI:0000 0001 0698 4037) 
15  University of California San Francisco, Global Brain Health Institute, San Francisco, USA (GRID:grid.266102.1) (ISNI:0000 0001 2297 6811); University of California San Francisco, Memory and Aging Clinic, San Francisco, USA (GRID:grid.266102.1) (ISNI:0000 0001 2297 6811) 
16  Universidad Adolfo Ibáñez, Latin American Brain Health Institute (BrainLat), Santiago, Chile (GRID:grid.440617.0) (ISNI:0000 0001 2162 5606); Universidad de San Andrés & CONICET, Cognitive Neuroscience Center (CNC), Buenos Aires, Argentina (GRID:grid.441741.3) (ISNI:0000 0001 2325 2241); Universidad de La Laguna, Instituto Universitario de Neurociencia, Tenerife, Spain (GRID:grid.10041.34) (ISNI:0000 0001 2106 0879); Universidad de La Laguna, Facultad de Psicología, Tenerife, Spain (GRID:grid.10041.34) (ISNI:0000 0001 2106 0879) 
17  Universidad Adolfo Ibáñez, Latin American Brain Health Institute (BrainLat), Santiago, Chile (GRID:grid.440617.0) (ISNI:0000 0001 2162 5606); Trinity College Dublin, Global Brain Health Institute, Dublin, Ireland (GRID:grid.8217.c) (ISNI:0000 0004 1936 9705); Universidad de San Andrés & CONICET, Cognitive Neuroscience Center (CNC), Buenos Aires, Argentina (GRID:grid.441741.3) (ISNI:0000 0001 2325 2241) 
18  Universidad Adolfo Ibáñez, Latin American Brain Health Institute (BrainLat), Santiago, Chile (GRID:grid.440617.0) (ISNI:0000 0001 2162 5606); University of California San Francisco, Global Brain Health Institute, San Francisco, USA (GRID:grid.266102.1) (ISNI:0000 0001 2297 6811); Trinity College Dublin, Global Brain Health Institute, Dublin, Ireland (GRID:grid.8217.c) (ISNI:0000 0004 1936 9705); Universidad de San Andrés & CONICET, Cognitive Neuroscience Center (CNC), Buenos Aires, Argentina (GRID:grid.441741.3) (ISNI:0000 0001 2325 2241) 
Pages
889
Publication year
2023
Publication date
2023
Publisher
Nature Publishing Group
e-ISSN
20524463
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41597-023-02806-8
ProQuest document ID
2899737716
Copyright
© The Author(s) 2023. corrected publication 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.