Abstract

OBJECTIVES: This study aimed to investigate the association of the epithelial and lymphoid immune markers with the adverse perinatal conditions such as early-onset preeclampsia (EOPE), fetal growth restriction (FGR) and intrauterine fetal death (IUFD) in preeclampsia in the placentae of preeclamptic patients.
MATERIAL AND METHODS: A total of 60 pregnant patients were included in this study. The immunohistochemistry method was used to determine the expression levels of CD4, CD8, CD4 / CD8, CD68, P53, MDM2, CK18, CK19, E-cadherin, and β catenin.
RESULTS: In our study, the increase in E-cadherin expression in the preeclamptic fetal-maternal placental region was associated with EOPE and FGR development preeclampsia and the decrease in the expression of CD4 and CD8, which are involved in the local immunomodulation, was associated with IUFD.
CONCLUSIONS: Our data reveal that the increase in the expression of CK18, CK19, E-cadherin, and β-catenin and the decrease in CD4 and CD8 play a role in the pathogenesis of preeclampsia.

Details

Title
Is the expression of placental epithelial and lymphoid markers associated with the perinatal outcomes in preeclampsia?
Author
Bayramoğlu, Zeynep 1   VIAFID ORCID Logo  ; Özler, Sibel 2   VIAFID ORCID Logo 

1  Department od Pathology Konya Education and Research Hospital, Konya, Türkiye. [email protected] 
2  Department of Perinatology, KTO Karatay University, Konya, Türkiye 
First page
929
End page
938
Publication year
2023
Publication date
2023
Publisher
Wydawnictwo Via Medica
ISSN
00170011
e-ISSN
25436767
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.5603/GP.a2023.0027
ProQuest document ID
2900203453
Copyright
© 2023. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.